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Von Willebrand Disease I

Breed: Poodles

Generic Phene Data

Breeds

General

Disease Name
Von Willebrand Disease I
Mutation
c.7142C>T
Mutation 2
c.7437G>A
Test Type
Genetic Disease/Disorder
Details
Von Willebrand?s disease (vWD) is a blood disease caused by a deficiency of von Willebrand Factor (vWF), an adhesive glycoprotein in the blood required for normal blood clotting. A lack of vWF impairs platelet stickiness and clumping. Symptoms can include: spontaneous hemorrhage from mucosal surfaces, nosebleeds, blood in the faeces, bloody urine, bleeding gums, excessive vaginal bleeding, bruising, prolonged bleeding after surgery or trauma, blood loss anemia. The inheritance of the severe forms (Types II and III) is autosomal recessive. The milder form (Type I) may be autosomal recessive or incompletely dominant. This is the most common hereditary blood clotting disorder in dogs.
Details 2
Von Willebrand?s disease (vWD) is a blood disease caused by a deficiency of von Willebrand Factor (vWF), an adhesive glycoprotein in the blood required for normal blood clotting. A lack of vWF impairs platelet stickiness and clumping. Symptoms can include: spontaneous hemorrhage from mucosal surfaces, nosebleeds, blood in the faeces, bloody urine, bleeding gums, excessive vaginal bleeding, bruising, prolonged bleeding after surgery or trauma, blood loss anemia. The inheritance of the severe forms (Types II and III) is autosomal recessive. The milder form (Type I) may be autosomal recessive or incompletely dominant. This is the most common hereditary blood clotting disorder in dogs.
Published
Brewer, G.J., Venta, P.J., Schall, W., Yuzbasiyan-Gurkan, V., Li, J. : DNA tests for von Willebrand?s disease in Dobermans, Scotties, Shelties and Manchester terriers. Canine Practice 23:45, 1998.

Breed Specific Data

Zoolyx

GTP
GTP Name
Zoolyx
Breed
Gene Name
VWF
Mutation
c.7437G>A

Wisdom Health (formerly Mars Veterinary)

GTP Name
Wisdom Health (formerly Mars Veterinary)
Breed
Gene Name
VWF
Mutation
c.7437G>A
GTP Breed
Poodles

VHL Genetics

GTP Name
VHL Genetics
Breed
Gene Name
VWF
Mutation
c.7437G>A

Progènes-ADN

GTP Name
Progenes ADN
Breed
Gene Name
VWF
Mutation
c.7437G>A

PharmaDNA

GTP
GTP Name
PharmaDNA
Breed
Gene Name
VWF
Mutation
c.7437G>A

Laboratorios Labocor S.L.

GTP Name
Laboratorios Labocor S.L.
Breed
Gene Name
VWF
Mutation
c.7437G>A

INNO

GTP
GTP Name
INNO
Breed
Gene Name
VWF
Mutation
c.7437G>A

GenSol Diagnostics

GTP Name
GenSol Diagnostics
Breed
Gene Name
VWF
Mutation
c.7437G>A

Genoscoper Laboratories Oy

GTP Name
Genoscoper Laboratories Oy
Breed
Gene Name
VWF
Mutation
c.7437G>A
GTP Breed
Poodles

CMSCH

GTP
GTP Name
CMSCH
Breed
Gene Name
VWF
Mutation
c.7437G>A

Certagen GmbH

GTP Name
Certagen GmbH
Breed
Gene Name
VWF
Mutation
c.7437G>A

BioBank AS

GTP Name
BioBank AS
Breed
Gene Name
VWF
Mutation
c.7437G>A

Anicom

GTP
GTP Name
Anicom
Breed
Gene Name
VWF
Mutation
c.7437G>A

Agrotis S.r.l.

GTP Name
Agrotis S.r.l.
Breed
Gene Name
VWF
Mutation
c.7437G>A
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