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Von Willebrand Disease III

Breed: Shetland Sheepdog

Generic Phene Data

Breeds

Relevance Rating: There is some evidence or research available for these breeds

Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful in this breed

General

Disease Name
Von Willebrand Disease III
Mutation
c.264delC
Mutation 2
c.2186+1G>A
Test Type
Genetic Disease/Disorder
Details
Von Willebrand?s disease (vWD) is a blood disease caused by a deficiency of von Willebrand Factor (vWF), an adhesive glycoprotein in the blood required for normal blood clotting. A lack of vWF impairs platelet stickiness and clumping. Symptoms can include: spontaneous hemorrhage from mucosal surfaces, nosebleeds, blood in the faeces, bloody urine, bleeding gums, excessive vaginal bleeding, bruising, prolonged bleeding after surgery or trauma, blood loss anemia. The inheritance of the severe forms (Types II and III) is autosomal recessive. The milder form (Type I) may be autosomal recessive or incompletely dominant. This is the most common hereditary blood clotting disorder in dogs.
Details 2
Von Willebrand?s disease (vWD) is a blood disease caused by a deficiency of von Willebrand Factor (vWF), an adhesive glycoprotein in the blood required for normal blood clotting. A lack of vWF impairs platelet stickiness and clumping. Symptoms can include: spontaneous hemorrhage from mucosal surfaces, nosebleeds, blood in the faeces, bloody urine, bleeding gums, excessive vaginal bleeding, bruising, prolonged bleeding after surgery or trauma, blood loss anemia. The inheritance of the severe forms (Types II and III) is autosomal recessive. The milder form (Type I) may be autosomal recessive or incompletely dominant. This is the most common hereditary blood clotting disorder in dogs.
Published
Rieger, M., Schwarz, H.P., Turecek, P.L., Dorner, F., Vanmourik, J.A., Mannhalter, C. : Identification of mutations in the canine von Willebrand factor gene associated with type III von-Willebrand-disease Thrombosis and Haemostasis 80:332-337, 1998. Pubmed reference: 9716162.

Breed Specific Data

The Kennel Club

GTP Name
The Kennel Club
GTP Disease Name
von Willebrand Factor III
Gene Name
VWF
Mutation
c.937delT
This test is outsourced to:
Weatherby's

Zoolyx

GTP
GTP Name
Zoolyx
Gene Name
VWF
Mutation
c.937delT

Wisdom Health (formerly Mars Veterinary)

GTP Name
Wisdom Health (formerly Mars Veterinary)
GTP Disease Name
von Willebrand Factor III
Gene Name
VWF
Mutation
c.937delT
Nature of test
mutation test
FCI Number
88
GTP Breed
Shetland Sheepdog

VHL Genetics

GTP Name
VHL Genetics
Gene Name
VWF
Mutation
c.937delT

VetGen LLC

GTP Name
VetGen LLC
Gene Name
VWF
Mutation
c.937delT

Veterinary Genetics Laboratory

GTP Name
Veterinary Genetics Laboratory
GTP Disease Name
von Willebrand Factor III
Gene Name
VWF
Mutation
c.937delT
Nature of test
mutation test
GTP- or Breed-Specific Publications
Pathak, EJ. Type 3 von Willebrand's disease in a Shetland sheepdog. Can Vet J 45:685-7, 2004. Pubmed reference: 15368744. (2004)
Inheritance
AR
FCI Number
88
GTP Breed
Shetland Sheepdog

Progènes-ADN

GTP Name
Progenes ADN
Gene Name
VWF
Mutation
c.937delT

PharmaDNA

GTP
GTP Name
PharmaDNA
Gene Name
VWF
Mutation
c.937delT

Paw Print Genetics

GTP Name
Paw Print Genetics
GTP Disease Name
von Willebrand Factor III
Gene Name
VWF
Mutation
Deletion
Nature of test
mutation test
FCI Number
88

Orivet Genetic Pet Care

GTP Name
Orivet Genetic Pet Care
GTP Disease Name
von Willebrand Factor III
Gene Name
VWF
Mutation
c.937delT
Nature of test
mutation test
FCI Number
88
GTP Breed
Shetland Sheepdog

Laboklin Gmbh & Co. KG

GTP Name
Laboklin Gmbh & Co. KG
GTP Disease Name
von Willebrand Factor III
Gene Name
VWF
Mutation
c.937delT
Nature of test
mutation test
FCI Number
88
GTP Breed
Shetland Sheepdog

Laboratorios Labocor S.L.

GTP Name
Laboratorios Labocor S.L.
Gene Name
VWF
Mutation
c.937delT

INNO

GTP
GTP Name
INNO
Gene Name
VWF
Mutation
c.937delT

GenSol Diagnostics

GTP Name
GenSol Diagnostics
GTP Disease Name
von Willebrand Factor III
Gene Name
VWF
Mutation
c.937delT

Genoscoper Laboratories Oy

GTP Name
Genoscoper Laboratories Oy
GTP Disease Name
von Willebrand Factor III
Gene Name
VWF
Mutation
c.937delT
Nature of test
mutation test
FCI Number
88
GTP Breed
Shetland Sheepdog

EVG Diagnostics

GTP Name
EVG Molecular Diagnostics
Gene Name
VWF
Mutation
c.937delT
Nature of test
mutation test
GTP- or Breed-Specific Publications
Can Vet J 2004;45:685?687

DNA My Dog

GTP Name
DNA My Dog
GTP Disease Name
von Willebrand Factor III
Gene Name
VWF
Mutation
c.937delT
Nature of test
mutation test
This test is outsourced to:
Orivet
FCI Number
88
GTP Breed
Shetland Sheepdog

CMSCH

GTP
GTP Name
CMSCH
Gene Name
VWF
Mutation
c.937delT

Certagen GmbH

GTP Name
Certagen GmbH
Gene Name
VWF
Mutation
c.937delT

CAG GmbH Center for Animal Genetics

GTP Name
Center for Animal Genetics
GTP Disease Name
von Willebrand Factor III
Gene Name
VWF
Mutation
c.937delT
Nature of test
mutation test
FCI Number
88
GTP Breed
Shetland Sheepdog

BioBank AS

GTP Name
BioBank AS
Gene Name
VWF
Mutation
c.937delT

Antagene

GTP
GTP Name
Antagene
GTP Disease Name
von Willebrand Factor III
Gene Name
VWF
Mutation
c.937delT
Nature of test
mutation test
Inheritance
AR
FCI Number
88
GTP Breed
Shetland Sheepdog

Anicom

GTP
GTP Name
Anicom
GTP Disease Name
von Willebrand Factor III
Gene Name
VWF
Mutation
c.937delT

Agrotis S.r.l.

GTP Name
Agrotis S.r.l.
Gene Name
VWF
Mutation
c.937delT
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