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Exercise-Induced Collapse / EIC

Breed: Clumber Spaniel

Generic Phene Data

General

Disease Name
Exercise-Induced Collapse / EIC
OMIA
1466
Gene Name
DNM1
Mutation
c.767G>T
Disease Code
EIC
Test Type
Genetic Disease/Disorder
Details
Affected dogs appear normal, and are capable of up to moderate exercise without incident. However, shortly after any strenuous exercise, they develop a wobbly gait with hindlimb weakness and incoordination, wide based stance, and walking with crouched hind legs. Signs can progress to full body weakness, extensor rigidity, and confusion. In extreme cases, it has been reported as fatal.
Details 2
Affected dogs have normal muscle mass, normal patellar reflexes before an episode of EIC, normal findings on muscle biopsy and are capable of moderate exertion without showing signs (Taylor et al., 2008, Patterson et al., 2008). Signs begin within 2 minutes after cessation of 5 to 15 minutes of strenuous exercise. Affected dogs develop a wobbly gait with hindlimb weakness and incoordination, wide based stance, and walking with crouched hind legs. Signs can progress to full body weakness, extensor rigidity, confusion, loss of consciousness, and rarely death. Episodes frequently last 5-10 minutes, often with complete recovery after 30 minutes. Loss of patellar reflexes persists after initial recovery.
Published
Patterson, EE., Minor, KM., Tchernatynskaia, AV., Taylor, SM., Shelton, GD., Ekenstedt, KJ., Mickelson, JR. : A canine DNM1 mutation is highly associated with the syndrome of exercise-induced collapse. Nat Genet 40:1235-9, 2008. Pubmed reference: 18806795. DOI: 10.1038/ng.224.
Published 2
Taylor, SM., Shmon, CL., Shelton, GD., Patterson, EN., Minor, K., Mickelson, JR. : Exercise-induced collapse of Labrador retrievers: survey results and preliminary investigation of heritability. J Am Anim Hosp Assoc 44:295-301, 2008. Pubmed reference: 18981194.
Body/System/Process
Neuromuscular
Inheritance
AR
Gene Name Text
dynamin 1

Breed Specific Data

Laboklin Gmbh & Co. KG

Link to GTP
GTP Disease Name
dynamin-associated exercise induced collapse, Exercise-induced hyperthermia, exercise related weakness
Gene Name
DNM1
Mutation
c.767G>T
Nature of test
mutation test

Veterinary Genetics Laboratory

Link to GTP
GTP Disease Name
dynamin-associated exercise induced collapse, Exercise-induced hyperthermia, exercise related weakness
Gene Name
DNM1
Mutation
c.767G>T
Nature of test
mutation test

Wisdom Health (formerly Mars Veterinary)

Link to GTP
GTP Disease Name
dynamin-associated exercise induced collapse, Exercise-induced hyperthermia, exercise related weakness
Gene Name
DNM1
Mutation
c.767G>T
Nature of test
mutation test

EVG Diagnostics

Link to GTP
Gene Name
DNM1
Mutation
c.767G>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Nature Genetics 40, 1235 - 1239 (2008)

University of Minnesota Canine Genetics Lab

GenSol Diagnostics

Link to GTP
GTP Disease Name
dynamin-associated exercise induced collapse, Exercise-induced hyperthermia, exercise related weakness
Gene Name
DNM1
Mutation
c.767G>T

GenSol Diagnostics

Link to GTP
GTP Disease Name
dynamin-associated exercise induced collapse, Exercise-induced hyperthermia, exercise related weakness
Gene Name
DNM1
Mutation
c.767G>T

Anicom

Link to GTP
GTP
GTP Disease Name
dynamin-associated exercise induced collapse, Exercise-induced hyperthermia, exercise related weakness
Gene Name
DNM1
Mutation
c.767G>T
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