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Coat Colour Panda White Spotting

Breed: ALL

Generic Phene Data

Breeds

Relevance Rating: There is some evidence or research available in this breed

ALL

Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful for these breeds

General

Disease Name
Coat Colour Panda White Spotting
Mutation
c.1960_1962delCTC
Mutation 2
p.Leu654del
Test Type
Other Genetic Traits
Details
The Panda coat pattern is characterized by symmetrical markings of white forelock, chest, abdomen, collar, muzzle, and tip of the tail. The amount of white can vary. In the homozygous state (2 copies of the mutation), the Panda mutation is considered embryonic lethal as no live dogs with the pattern and with 2 copies of the mutation have been observed. Heterozygous (1 copy of the mutation) dogs do not have any reported health defects associated with this coat pattern.
Details 2
Variable degree of white spotting ranging from tiny white spots up to completely white animals. The absence of pigment is caused by the absence of skin melanocytes. The white-spotting allele appears to be autosomal dominant with respect to coat colour and recessive lethal.
Published
Wong, A.K., Ruhe, A.L., Robertson, K.R., Loew, E.R., Williams, D.C., Neff, M.W. : A de novo mutation in KIT causes white spotting in a subpopulation of German Shepherd dogs. Anim Genet 44:305-10, 2013. Pubmed reference: 23134432. DOI: 10.1111/age.12006.

Breed Specific Data

Zoolyx

GTP
GTP Name
Zoolyx
Breed
ALL
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del

Progènes-ADN

GTP Name
Progenes ADN
Breed
ALL
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del

PharmaDNA

GTP
GTP Name
PharmaDNA
Breed
ALL
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del

Laboratorios Labocor S.L.

GTP Name
Laboratorios Labocor S.L.
Breed
ALL
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del

INNO

GTP
GTP Name
INNO
Breed
ALL
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del

CMSCH

GTP
GTP Name
CMSCH
Breed
ALL
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del

BioBank AS

GTP Name
BioBank AS
Breed
ALL
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del

Agrotis S.r.l.

GTP Name
Agrotis S.r.l.
Breed
ALL
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del

Certagen GmbH

GTP Name
Certagen GmbH
Breed
ALL
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del

VHL Genetics

GTP Name
VHL Genetics
Breed
ALL
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del

Veterinary Genetics Laboratory

GTP Name
Veterinary Genetics Laboratory
Breed
ALL
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del
Nature of test
mutation test
GTP- or Breed-Specific Publications
Wong AK, AL Ruhe, KR Robertson, ER Loew, DC Williams and MW Neff. A de novo mutation in KIT causes white spotting in a subpopulation of German Shepherd dogs. Animal Genetics 2013 Jun;44(3):305-310. doi: 10.1111/age.12006. Epub 2012 Nov 8.
FCI Number
-20
GTP Breed
ALL
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