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Coat Colour, Dominant Black

Breeds
ALL

General

Disease Name
Coat Colour, Dominant Black
Disease Name 2
Coat Colour K-locus
OMIA
1416
Gene Name
CBD103
Mutation
A 3-base pair (bp) deletion in the second exon of CBD103
Test Type
Other Genetic Traits
Details
The K locus, or Dominant Black, refers to testing for the K-locus. There are a number of factors for determining a dog's visible (phenotype) coat colour and pattern, as many genes are involved to create a dog's coat. Within the K locus options include: dominant black - where a dog has inherited at least one K gene, will be solid black, (Kk, KK), kk can show tan markings, kbr - brindle, k - recessive non-black. Dominant black dominates the whole of the A locus, but it can be modified by other genes, such as liver, dilution, greying and merle. That black coat can then be changed to liver, blue, isabella or merle. The K locus plays a pivotal role in coat color. This locus is a relative newcomer in our understanding of canine color, and includes traits formerly attributed by some to other genes.
Details 2
The K locus, or Dominant Black, refers to testing for the K-locus. There are a number of factors for determining a dog's visible (phenotype) coat colour and pattern, as many genes are involved to create a dog's coat. Within the K locus options include: dominant black - where a dog has inherited at least one K gene, will be solid black, (Kk, KK), kk can show tan markings, kbr - brindle, k - recessive non-black. Dominant black dominates the whole of the A locus, but it can be modified by other genes, such as liver, dilution, greying and merle. That black coat can then be changed to liver, blue, isabella or merle. The K locus plays a pivotal role in coat color. This locus is a relative newcomer in our understanding of canine color, and includes traits formerly attributed by some to other genes.
Published
Candille, SI., Kaelin, CB., Cattanach, BM., Yu, B., Thompson, DA., Nix, MA., Kerns, JA., Schmutz, SM., Millhauser, GL., Barsh, GS. : A {beta}-Defensin Mutation Causes Black Coat Color in Domestic Dogs. Science 318:1418-23, 2007. Pubmed reference: 17947548. DOI: 10.1126/science.1147880.
Published 2
Kerns, JA., Cargill, EJ., Clark, LA., Candille, SI., Berryere, TG., Olivier, M., Lust, G., Todhunter, RJ., Schmutz, SM., Murphy, KE., Barsh, GS. : Linkage and segregation analysis of black and brindle coat color in domestic dogs. Genetics 176:1679-89, 2007. Pubmed reference: 17483404. DOI: 10.1534/genetics.107.074237.
Published 3
Oguro-Okano, M., Honda, M., Yamazaki, K., Okano, K. : Mutations in the melanocortin 1 receptor, ?-defensin103 and agouti signaling protein genes, and their association with coat color phenotypes in Akita-inu dogs. J Vet Med Sci 73:853-8, 2011. Pubmed reference: 21321476.
Body/System/Process
Coat Colour/Pattern/Type
Inheritance
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