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Coat Colour Yellow/Red, Melanistic Mask

Breeds

Relevance Rating: Unknown, not evaluated or no evidence for test in this breed

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General

Disease Name
Coat Colour Yellow/Red, Melanistic Mask
Mutation
g.1875_1890dupCCCCAGGTCAGAGTTT
Mutation 2
unpublished
Test Type
Other Genetic Traits
Details
The "E" locus influences a number of different ways for coat colour to be expressed. "E" allele, allows the dog to produce eumelanin (black pigment). The "e" allele causes the pigment-producing cells to only produce phaeomelanin. A dog must have two copies of the "e" MC1R mutation to express the yellow or red coat color. Recessive red can mask other color variants, including merle. "Em" is dominant, causing the dog to have a black, or melanistic mask. The genetics of coat colour, and predicting phenotype are complicated by influences of dominant traits, underlying coat colour, and coat pattern influences. The dog's color can vary greatly with different mutated alleles on other genes. Dogs that are "ee" will always be yellow. It is important to seek advice if breeding for a particular colour/pattern.
Details 2
The "E" locus influences a number of different ways for coat colour to be expressed. "E" allele, allows the dog to produce eumelanin (black pigment). The "e" allele causes the pigment-producing cells to only produce phaeomelanin. A dog must have two copies of the "e" MC1R mutation to express the yellow or red coat color. Recessive red can mask other color variants, including merle. "Em" is dominant, causing the dog to have a black, or melanistic mask. The genetics of coat colour, and predicting phenotype are complicated by influences of dominant traits, underlying coat colour, and coat pattern influences. The dog's color can vary greatly with different mutated alleles on other genes. Dogs that are "ee" will always be yellow. It is important to seek advice if breeding for a particular colour/pattern.
Published
Dreger, D.L., Parker, H.G., Ostrander, E.A., Schmutz, S.M. : Identification of a mutation that is associated with the saddle tan and black-and-tan phenotypes in Basset Hounds and Pembroke Welsh Corgis. J Hered 104:399-406, 2013. Pubmed reference: 23519866. DOI: 10.1093/jhered/est012.
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