Canine Histiocytic Malignancy (HM)
General
Disease Name
Canine Histiocytic Malignancy (HM)
OMIA
-56
Gene Name
proprietary
Mutation
CADET HM assay
Test Type
Diagnostic Tool
Details
Histiocytic Malignancy (HM) is a typically aggressive canine cancer that can arise in a wide variety of locations, often affecting multiple sites in abdominal organs and the skin. Several breeds are highly predisposed, especially the Bernese Mountain Dog and the Flat-Coated Retriever, and also the Rottweiler and Golden Retriever; however any breed may be affected. The most common approach for diagnosis of HM involves taking a biopsy of the tumor mass, and examining this tissue under the microscope, but this method is often inconclusive. The CADET SM HM ASSAY determines the number of copies of a specific DNA sequence present in the tumor cells of suspected HM cases. A reduction in the number of copies present is consistent with a diagnosis of HM. The assay has been validated by screening over 500 unique tumor samples including HM, lymphoma, hemangiosarcoma, amelanotic melanoma, mast cell tumor and plasmacytoma. The results show this genetic signature to be a highly sensitive and specific marker for identification of HM. (from Sentinal Biomedical) Available from veterinary professionals only.
Details 2
Histiocytic malignancy (HM) is a typically aggressive canine cancer that can arise in a wide variety of anatomical locations, often affecting multiple sites in abdominal organs and the skin. Several breeds are highly predisposed, notably the Bernese Mountain Dog and the Flat-Coated Retriever, in which HM contributes to up to 50% of all deaths. Other commonly affected breeds include the Golden Retriever and the Rottweiler; however, any breed may be affected. Diagnosis of HM can be highly challenging and is often achieved through sequential exclusion of other likely differentials. The prognosis for dogs diagnosed with HM is very poor, with typical mean survival of less than two months. Unfortunately, the rapid progression and lack of effective treatments means that many HM cases are euthanized within days of diagnosis. The CADET SM HM ASSAY determines the number of copies of a specific DNA sequence present in the tumor cells of suspected HM cases. A reduction in the number of copies present is consistent with a diagnosis of HM. The assay has been validated by screening over 500 unique tumor samples including HM, lymphoma, hemangiosarcoma, amelanotic melanoma, mast cell tumor and plasmacytoma. The results show this genetic signature to be a highly sensitive and specific marker for identification of HM. (from Sentinal Biomedical) To be utilized by veterinary professionals.
Body/System/Process
Multisystem
Inheritance
Diagnostic
Breed Specific Info
Researched Breeds
Bernese Mountain Dogs
Breed-specific 1
Bernese Mountain Dogs