Chronic Superficial Keratitis
General
Disease Name
Chronic Superficial Keratitis
OMIA
1287
Gene Name
unpublished
Mutation
DLA-DRB1*01501/DQA1*00601/DQB1*00301 allele
Test Type
Genetic Disease/Disorder
Details
The cause of this disease was long considered to be multifactorial and not clearly understood. However, recent research suggests it is autosomal dominant, and a test is available. CSK is usually a progressive condition, effecting both eyes. The lesions that develop are not usually symmetrical nor are they usually painful. Severe cases can cause blindness. A diagnosis is usually established by ophthalmic examination of the eye.
Details 2
The etiology of this disease is multifactorial and not clearly understood. CSK is usually a bilateral progressive condition, however the lesions are not usually symmetrical nor are they usually painful. Signs include pigmentation and vascularization of the cornea (extension of blood vessels onto the cornea). It is usually first seen at the lateral (temporal) limbus (the junction between the cornea and sclera), although it eventually can extend from any part of the limbus to cover the entire cornea. Severe cases can cause blindness. A diagnosis is usually established by ophthalmic examination of the eye.
Published
Cheng, S., Wigney, D., Haase, B., Wade, C.M. : Inheritance of chronic superficial keratitis in Australian Greyhounds. Anim Genet 47:629, 2016. Pubmed reference: 27147552. DOI: 10.1111/age.12446.
Published 2
Jokinen, P., Rusanen, E.M., Kennedy, L.J., Lohi, H. : MHC class II risk haplotype associated with canine chronic superficial keratitis in German Shepherd dogs. Vet Immunol Immunopathol 140:37-41, 2011. Pubmed reference: 21144596. DOI: 10.1016/j.vetimm.2010.11.007.
Published 3
Lynch, G.L. : Ophthalmic examination findings in a group of retired racing Greyhounds. Vet Ophthalmol 10:363-7, 2007. Pubmed reference: 17970997. DOI: 10.1111/j.1463-5224.2007.00570.x.
Body/System/Process
Eye
OMIA Url
Inheritance
AD
Breed Specific Info
Researched Breeds
Greyhound, German Shepherd