"In this Canine Health Foundation webinar Dr. Danika Bannasch, DVM, PhD University of California, Davis, School of Veterinary Medicine, discusses the major advances that have been made in our understanding of the molecular basis for inherited diseases in dogs. These advances, in the form of DNA based tests for breeding animals have changed that way breeders make breeding decisions. During the webinar Dr. Bannasch will discuss the basics of dog genetics, the different modes of inheritance or how genetic traits and diseases are transmitted from one generation to the next and the exceptions to the basic modes of inheritance."
"Elaine Ostrander provides an overview of canine genetics, and explains how scientists are using genetics to decipher the molecular basis of different traits such as height and cancer risk. Talk Overview: Although all domestic dogs belong to the same species, different breeds display unique morphological traits and different disease susceptibility. Dr. Elaine Ostrander provides an overview of canine genetics, and explains how scientists are using genetics to decipher the molecular basis of different traits such as height and cancer risk. In her second lecture, Ostrander explains that canine genetics can be used to understand disease susceptibility and cancer risk. By analyzing the pedigree of dogs, her laboratory identified a series of genes involved in the elevated cancer risk of particular dog breeds.
Specifically, her laboratory studied invasive transitional cell carcinoma of the bladder, a disease for which breeds like Scottish Terriers have a high susceptibility. In human cases of this disease, the cause is unknown in 50% of patients. Ostrander’s laboratory identified genetic mutations that explain the elevated cancer risk in these dogs. This information may improve diagnosis and targeted therapy in dogs and humans..."