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Found 21 results

  1. This article describes the role of Genetic Test Providers (GTPs) in the Harmonization of Genetic Testing for Dogs (HGTD) initiative, provides information on who they are and why they participate, and defines processes and levels of participation for current and prospective collaborating GTPs.
  2. New in 2020: Genetic tests listed by breed include a 'relevance rating'. Here is what that is and why it is important. A work in progress... this will be a dynamic index that may change as new information becomes available. Essentially, it is a visual expression of the level of evidence we have for the use of a given test in a specific breed. The red, yellow, green ('traffic-light') layout is shown in paw prints beside the test listing returned in a breed search (see below), or as coloured badges on the Generic Phene page.
  3. And not all dams and sires with 'clear' test results will be good choices for breeding. Oh, would that life and breeding decisions could be made easy! But every experienced breeder knows that nothing is simple. Breeding and inheritance and health and temperament are very complex issues - each on their own - and combined they constitute a puzzle with no guaranteed solutions. With the increased availability of genetic testing, with its media-inspired aura of high-tech infallibility and direct-to-consumer marketing campaigns, there has been a rush to embrace it as THE most important pre-breeding test. It is probably underpinned by the vague hope of breeders that IF they spend their money and do all the possible genetic tests, they will have fulfilled their 'due diligence''. Many of my colleagues and I have repeatedly reminded the breeding community that, in spite of genetic testing being an extremely important decision-making tool, it is crucial that attention be paid to conditions that are considered important for a breed - regardless of whether there is a 'DNA test' for the condition, or even any test at all The Big Picture is crucial. I described in another blog a genetics symposium in Canada in November 2019. During discussions with committed breeders, at we came to some very important questions. For example, everyone says they want healthy animals with good longevity. But think about these items before you nod your head: How many breeders could say that those are the primary criteria they use when selecting mating pairs? Is there good evidence in your breed that the main focus of breeding has been on producing healthy, long-lived offspring? When breeders choose inbreeding or line-breeding is it to improve health and longevity, or, more likely, aimed at fixing specific traits, often to do with appearance? These questions are not meant as any judgement but to provoke critical, rational, logical thinking about breeding decisions which are, for better or worse often influenced by something else. Primarily, people need to look honestly at the history and culture of breeding and admit that, as for anything in life, a) saying and wishing and hoping is not doing; and b) you cannot achieve a theoretical or even heartfelt goal if your actions are in direct opposition to its achievement. I say I am committed to being slender and fit and then spend all my time in front of the computer and maintain a deep and satisfying relationship with potato chips. But at least I am not shocked when the slender-fit thing just doesn't happen. Our IPFD friend and collaborator Ian Seath posted another recently called 'Health-tested does not mean healthy'. And rightly highlights that health and longevity (or 'healthgevity') is a function of many factors beyond breeding or genetics. Owners must do their part to maintain health and not push all blame for ill-health to breeders. E.g. the well-loved, but morbidly obese Pug in this shot, had, by nature and breeding, specific health risks, all, no doubt aggravated by its body condition. All stakeholders in the health and welfare of individual dogs and breeds need to contemplate their roles and take responsibility. More coming on the topic of health testing and health, soon.
  4. In our final installment of the Digest for 2019, we are putting the spotlight on 2019 milestones, and looking forward to 2020 – which promises to be a pivotal year for IPFD and DogWellNet.com. In 2019, our fifth full year of operation, we focused our efforts on several key initiatives, including: the Harmonization of Genetic Testing for Dogs (HGTD); the 4th International Dog Health Workshop (IDHW); the continued growth of DogWellNet.com and our online community. We provided an independent voice in addressing complex and often controversial challenges, including "Hot Topics" such as canine genetics; and shared resources e.g. on health and welfare issues in brachycephalic breeds. See other interviews and news reports featuring IPFD here. As a start up non-profit five years ago, we represented a good idea, with an admirable mission. Many were enthusiastic about the concept, but perhaps unclear about the details of what could be accomplished. IPFD developed based on a strategy of 'if we build it, they will come'. The progress has been gratifying, but never fast enough for me, personally. The acknowledgement of the need for multi-stakeholder, international collaboration and action is widespread; but the realities of the dog world and the demands of local, regional, and national responsibilities of our volunteers and collaborators continues to pose challenges. As we move into a phase of enhancing stability and sustainability, we have a lot to celebrate and great potential on which to capitalize. The word cloud created from participants' comments from the 4th International Dog Health Workshop exemplifies many of our issues, goals, and efforts We have a substantial focus on science and evidence, but we never forget that the human element underpins everything we do. Our Spotlight video in December's Digest shows a softer side, reminding us that it is our love and appreciation for dogs that motivates us. People are always the strength of an organization, and now is a good time to acknowledge and thank the small but committed team of consultants who do the lion's share of work at IPFD. Please check out their profiles and read more about their efforts, below and in the Digest. The IPFD Board has gone through a transformation in 2019, with three members transitioning off the Board and five enthusiastic new Board members joining. The Board now comprises both old friends and new faces with renewed energy and purpose to help launch IPFD into the new decade, capitalizing on existing strengths and addressing ongoing challenges. Bios for the Board are here; we can all look forward to learning more about them in our 2019 Annual Report, and hearing from them in articles and blogs. In the spirit of the season, below are some highlights from 2019 – these could make for some great holiday reading! Thanks to everyone who has supported IPFD and participated in our work in 2019. And here's to a stellar 2020... as we leap ahead with great aspirations. New IPFD Contributors We welcomed two new Contributing Partners in 2019: The Canadian Kennel Club (January) Raad van Beheer (The Dutch Kennel Club) the official kennel club of The Netherlands (February). A new two-year Sponsor, the Morris Animal Foundation (July). And several Non-Breed Specific Collaborators, which are organizations serving health and welfare interests for all breeds: European School for Advanced Veterinary Studies (ESAVS) (June) Global Pet Obesity Initiative (August) And going into 2020, we have renewed and ongoing contracts with all existing Contributing Partners! Harmonization of Genetic Testing for Dogs (HGTD) The HGTD Project has seen significant growth in 2019, and currently lists 76 Genetic Test Providers (GTPs) across 22 countries, worldwide with 42 currently participating or starting their participation. Thanks to Project Director Aimee Llewellyn-Zaidi! We have made several improvements to the information we record for both genetic test providers and test information. This includes clearer information on what laboratories are used for outsourced testing and when information has been updated by GTPs. Thanks to our App developer Michael Edwards (Coding Jungle), we continue to further automate the updating process and add on new functions. See further details on HGTD in the Digest. In 2020, in addition to expanding engagement with GTPs, we will integrate various projects (Expert Panel, Health Strategies Database (HSDD), the Get a GRIHP Program) to enhance breed-specific information and outputs. Read about these initiatives in Brenda's presentation under Breed-Specific Health Strategies at the 2019 4th IDHW, here. 4th International Dog Health Workshop (IDHW) The IDHWs bring together a wide range of stakeholders in dog health, science, and welfare to improve international sharing of information and resources, provide a forum for ongoing collaboration, and identify specific needs and actions to improve health, well-being, and welfare in dogs. IPFD is responsible for the International Dog Health Workshops and partners with other organizations who manage meeting logistics. Access the amazing resources from the four IDHWs here. The 4th IDHW, co-hosted by the Kennel Club in Windsor, UK, in May/June 2019, included more than 130 decision leaders from 17 countries, who joined us to share their experiences and expertise across five Themes addressing some of the most pressing issues in the dog world. We’ve compiled pre- and post-meeting resources here, both for the benefit of workshop participants and for those who were unable to attend. We continue to see the dividends of the important work done at the first three IDHWs (read more in our publication from the Paris 3rd IDHW and look for a new publication in the Journal of Canine Epidemiology and Genetics in 2020), and Working Groups have begun work on issues addressed at the 4th IDHW earlier this year. The 5th IDHW takes place in 2021, with the date and location to be confirmed soon! DogWellNet.com Our internet platform, DogWellNet.com, is an open access, ever-expanding information hub, providing links, documents, and additional resources to breeders and others in the dog world. For an overview of the site, including an explanation of key content areas and features, please visit DogWellNet.com: At A Glance. Although almost all DogWellNet content is available to guests, we encourage readers to sign up as members on the site. As of the publishing date for this issue, more than 1,200 people have signed up on DogWellNet.com, including more than 500 Members and 700+ Advanced Members. One of the popular resources on the site is the Breeds Database, ably overseen by our Content Manager Ann Milligan. A former breeder, and current judge, Ann is always thrilled to get information from breed clubs and breeders, as we continue to expand this resource. In 2020, there will be further integration of material from the breeds database with our other initiatives (HGTD; HSDD, etc.). DogWellNet Digest This is our eighth 2019 issue of DogWellNet Digest – a collection of the latest news from IPFD and DogWellNet.com. A link to each new issue is emailed to all IPFD Members and posted to our social media accounts, and all previous issues are archived on DogWellNet.com. See also IPFD in the Media for excerpts or links to published articles, etc. that reference IPFD or DogWellNet. IPFD Social Media In 2019, our social media presence expanded further into the dog world with several targeted campaigns and a growing following of our Facebook, Twitter, and LinkedIn accounts. Thanks to Dave St. Louis, our Communications Specialist, for keeping us in touch with our Partners, Members, and the dog world, in general. Another key online tool is our video resources. See our latest, a feel-good offering for the season, and tantalizing, early glimpse of our 2019 Annual Report. Enough looking back, let's talk about... Moving Forward in 2020 With additions to HGTD and other genetic counseling resources, implementation of the Expert Panel, creation of the HSDD, planning for the 5th IDHW; enhanced activities with our revitalized Board, ongoing outreach with our Partners and Sponsors...the possibilities are exciting! All the best for the holiday season and Happy New Year from IPFD...where every year is the Year of the Dog.
  5. The HGTD arose from discussions at the IPFD International Dog Health Workshops (IDHWs); it is a proud achievement, exemplifying the IDHW tagline: Information – Collaboration – Action! In 2019, the HGTD project could be summarized in one word: Growing. We’ve consistently grown our list of genetic test providers (GTPs). Participating GTPs have provided information on their accreditation, expertise, and practices – all of which helps individuals find a GTP that has the quality measures most important to them. The generic phenes database provided a centralized resource for researchers, vets, and owner/breeders, spurring unexpected benefits. We’ve seen more consistency in test naming among international providers, benefiting owners seeking testing information. It also allowed international researchers to spot industry-wide challenges, and have them addressed through a centralized platform. To better support dog owners, the veterinary community, and dog health advisors, we introduced Breed Relevancy Ratings across genetic tests. The HGTD database relevance rating indicates the amount of available evidence supporting the relevance of a specific genetic test for a specific breed/type. Currently, the relevance rating is based on a wide-variety of evidence sources. This includes peer-reviewed research papers, recommendations from the original researchers/test developers, input from additional experts including veterinary specialists, and breed experts. It is hoped that, by being more informative about what we currently know or do not know about a specific test for a specific breed, that dog health advisors and owners can make more informed decisions. The collaboration across the dog world, and the participation of those in the testing industry, dog owners, and experts around the globe, has helped to shape our achievements for 2019 and develop exciting plans for 2020.
  6. How to Use The HGTD: Welcome to the Harmonization of Genetic Testing for Dogs resource. This resource is designed to improve standardization of, and access to, robust genetic testing to support health improvements and a sustainable future for healthy dogs. Here, you’ll find a wealth of information on Genetic Testing Providers (labs); genetic tests, and tests by breed. There are two major components of the HGTD: the Quality Testing Database and Genetic Counselling resources (still in development).
  7. The Animal Health Trust exists to fight disease and injury in animals. Thanks to our pioneering work improving diagnosis, treatment and prevention, horses, dogs and cats are living healthier, happier lives – in the UK and across the world. The Animal Health Trust is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.
  8. Embark is more than a product, or even a company. It is a promise to share the journey of a lifetime with you and your dog. You invite us, via our app and website, into your home to help you understand and care for your dog like never before. We invite you to join us in making new discoveries in dog health, wellness, care, and understanding: via our research questions, regular results updates, blog posts, social media, and events. Embark is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.
  9. From - Standards, Health and Genetics in Dogs - Chapter II - Genetic testing in dogs - Marie Abitbol (France) "The first part of this chapter presents the genetic characteristics of the canine species and the basics of canine genetics. The second part addresses the use of screening and diagnostic tests for inherited diseases, with a focus on genetic counselling and the parameters that determine the interpretation of test results. The third part concentrates on the search for informations on canine inherited diseases and the tests available. The final part presents tests for aesthetic characteristics such as coat colour."
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    Jerold Bell outlines concerns involved with use of genetic tests - 2012 IDHW
  11. I was honoured to again be invited to speak at the 2019 AKC Canine Health Foundation National Parent Club Canine Health Conference August 9-11 in St. Louis, Missouri. This is a great event that brings together breed club health committee members, other interested breeders, stellar researchers, and others from the dog community. There was a broad coverage of CHF sponsored research topics, as well as a definite focus on genetics and genetic testing, reflecting the continued need for information and support for the dog community on these issues. In addition to lectures, there were two panel discussions which allowed attendees to ask questions of the scientists. The first was on Saturday afternoon. I gave my talk on Sunday, and that session was also followed by a panel discussion. A pdf copy of my talk, with post-talk notes, is attached: BONNETT CHF Harmonization of Genetic Testing and Breed Specific Resources 11Aug2019_with notes.pdf As I note in this document, I heard a lot of frustration from those asking questions, and others who approached me over the weekend. As I said to all of them, "It is not surprising that you are confused and frustrated... the world of genetic testing IS confusing and frustrating!". Although many exciting developments in genetic research were presented over the weekend, and other talks focused on application of testing, there were few if any simple, yes/no, black and white answers. 'Genetics' underlies all life in our universe, is the basis of all evolution... it is not now, nor will it ever be, simple, uncomplicated and, perhaps, never really fully understood. Even while we are struggling to get a hold on the appropriate use of the many tests available for single-gene disorders, some researchers are moving ahead on diseases with a more complex inheritance. And even now the research world is moving more and more into whole-genome sequencing, which may be available at a reasonable price within a couple of years. And then what? We will know more and more about the genetic makeup of individuals and breeds. But will we have the detailed information needed on the meaning of all these results? The key information for properly integrating genetic testing into best breeding practices? Probably not. As is the current situation, the technology will likely advance faster that our ability to deal with it in a practical sense. And, for all the potential good, there are significant risks to applying tests in the face of insufficient clinical/population-based information. This same situation is also arising in human medicine; a topic I touched on in my recent talk at the American Veterinary Medical Association meeting. Leigh-Anne Clark from Clemson University gave a great talk on risk across the various combinations of a three genes associated with dermatomyositis - combinations which highlighted the added complexity of multi-gene disorders. (see abstract: pg. 68) Her work also showed the kind of explicit risk percentages that are needed to really understand the results from genetic testing. We recently posted on Facebook a link to a video of a previous talk Dr. Clark gave which is well worth viewing. Another recurring challenge brought up by attendees involved breed clubs' frustrations in communicating health strategies to their members and in achieving compliance with recommendations. I mention in my talks 'Decision making by Facebook'. Unfortunately, the latter drives a lot of the focus for many in kennel and breed clubs. Several clubs brought up instances where rare diseases, or diseases with unknown importance in their breed, were being pushed forward to have a genetic testing strategy, sometimes taking emphasis away from common, known, important conditions in the breed. Several of the experts recommended not basing testing strategies for such condition just because a test was available, but rather looking at the big picture of health in the breed. It became quite clear that many of breed club's frustrations stem not from a lack of research or information or having complex information, but on an inability to effect behaviour change in their members through traditional channels of education. This was a common theme at the IDHW as well and we brought in experts on Human Behaviour Change for Animals to educate us. I personally think that learning how to communicate more effectively is desperately needed. All these concerns and experiences underlie IPFD's work on improving and expanding the tools needed to deal with genetic testing and health strategies in breeds. See my talk from the CHF meeting for information on the latest work on the Harmonization of Genetic Testing for Dogs (HGTD), a coming development, the Health Strategies Database for Dogs that will catalog all conditions in breeds (not just those for which there are genetic tests based on identified health issues from breed clubs, kennel clubs, and others worldwide. We are starting a project in Golden Retrievers as a prototype of our Get a GRIHP! tool to pull all relevant information together for a breed. It is so wonderful to meet with those people so passionate about health in their breeds. Thanks to AKC-CHF and all the attendees for a great experience.
  12. See Downloads - 4th IDHW Theme Outcomes Presentations (below) Article: Report from the Genetic Testing Theme, from the 4th International Dog Health Workshop (8-5-2019) This article summarizes the pre-thru-post 4th IDHW meeting activities around the Genetic Testing theme. Please note that additions and changes may occur. We will be welcoming comments and suggestions from participants in the workshop and working groups as we move forward. Please contact Aimee at aimee.llewellyn-zaidi@ipfdogs.com.
  13. A recent publication authored by members of the HGTD puts forward a suggested system of standards and guidelines for canine genetic testing laboratories. Standards and guidelines for canine clinical genetic testing laboratories https://link.springer.com/article/10.1007%2Fs00439-018-1954-4 ______________________________________________________________________________________________________________ See the IPFD commentary on this publication, in the context of Improving Canine Genetic Testing. _______________________________________________________________________________________________________________ First Online: 13 November 2018... The paper sets out a series of standard requirements the authors feel should provide both minimum and optimal standards for any canine genetic testing laboratory, including: personnel, facilities, quality practices, privacy issues, and a section on test validation and results reporting. A self-assessment check list is also available. While not all aspects of the self-assessment will be applicable to all genetic test providers, it is one way that test providers may choose to improve the quality of direct to consumer genetic testing.
  14. Harmonization of Genetic Testing for Dogs (HGTD) - YouTube A tool to help dog owners, breeders and veterinarians, the HGTD is an online searchable database providing information on genetic tests available for dog breeds, information on the tests themselves and quality control measures used by genetic test providers participating in the HGTD. HGTD playlist
  15. HGTD - A quick look at the Search by Breed functionality. Go to the Harmonization of Genetic testing Search by Breed
  16. VetVine Hub Uploaded on Dec 9, 2017 The increasing availability of genetic screening tests, DNA tests, and now multiplex test panels also requires an understanding of what the tests tell you.
  17. Many thanks to the AKC-CHF and our other sponsors for supporting the collaborative Harmonization of Genetic Testing initiative!!! See the Dog News Annual Issue for the complete article.
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