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Aimee Llewellyn-Zaidi posted a blog entry in New Research2019 Lewis TW, Mellersh CS. Changes in mutation frequency of eight Mendelian inherited disorders in eight pedigree dog populations following introduction of a commercial DNA test. Plos One, https://doi.org/10.1371/journal.pone.0209864 DNA Testing - General Subject: DNA Testing Type: Research Journal/Source: peer-reviewed research publication Authors/Researchers: University, Kennel Club (IPFD Partners); HGTD Participants Recommended For: Veterinarians, Owners/Breeders This study is one of the very few to investigate the impact of DNA testing on changing a dog population's disease risk. The research looked at determining changes in frequency of disease causing mutations (how common a mutant gene is in a population) as a result of breeding-pair selection based on DNA test results. The results indicated that there has been an overall decline in disease causing mutations in the 8 diseases in 8 breeds investigated. While the paper recognises that there can be variations in how quickly a disease is reduced or eliminated (such as breed population size), it concluded that where dog breeders appear to incorporate DNA test results as part of breeding plans, there is success in decreasing the frequency of mutation. The study looked at: prcd-PRA in Labrador Retriever and Cocker Spaniel, HC in Staffordshire Bull Terriers, EIC in Labrador Retriever, PLL in Mini-Bull Terrier, EF and DE/CC in Cavalier King Charles Spaniel, PRA rcd-4 in Gordon, and Irish Setter, and spinocerebellar ataxia in Parson Russell Terrier. Within the UK at least, this represents a spectrum of large and small breeds, and generally "known" diseases within the breeds. 2019 Lewis TW, Mellersh CS. Changes in mutation frequency of eight Mendelian inherited disorders in eight pedigree dog populations following introduction of a commercial DNA test. Plos One, https://doi.org/10.1371/journal.pone.0209864 See also: Nearly 20 Years of DNA Testing – What Can We Learn? : IPFD CEO's blog post with discussion of wider implications of the study's approach and findings; based on Ian Seath's commentary (Dog-ED: Social Enterprise) with a breeder/health council perspective on the article above. IPFD Harmonization of Genetic Testing (HGTD) and search on the mentioned diseases for more information on the the condition, phenes, tests and more.
Here you will find an overview of breed resources on DogWellNet.com. This is not a comprehensive listing - it is a starting point for finding relevant resources. Please visit the various areas of the site using the purple navigation bar and/or the Search function.
Several recent articles have raised concerns about the quality of canine genetic testing. There is concern about the quality measures, standards and practices of genetic test providers (GTPs), but there are also factors related to test discovery, validation and application that may limit our ability to get the most out of genetic testing. Confusion, lack of transparency, absence of needed information on many levels, and incomplete understanding of the situations, individuals and breeds where testing is most useful are among the challenges. This article is in response to numerous queries and discussions on what is needed to improve the situation.
Ann Milligan posted a article in Population | Breed LevelThe book, Standards, Santé et Génétique chez le Chien / Standards, Health and Genetics in the Dog was created by the Société Centrale Canine (SCC) in collaboration with the Fédération Cynophile Internationale (F.C.I.) and the Swedish Kennel Club (SKK). Under the direction of Claude Guintard and Grégoire Leroy, the publication was presented as a tribute to Mrs. René Sporre-Willes and Mr. Raymond Triquet, longstanding chairs of the F.C.I.'s the Standards Commission, at the Third IPFD Dog Health Workshop held in Paris from April 21 to 23, 2017. Standards, Santé et Génétique chez le Chien / Standards, Health and Genetics in the Dog presents information from the world of dogs which can be applied in service to canine and human health and well-being. This work includes contributions by veterinarians, researchers, and dog-theorists who offer insights into the development of breed standards as well as the incredible advances in molecular genetics. We at DogWellNet are delighted to be able to present the content from this book's 396 pages which includes 20 texts in English and in French distributed in two large chapters. The book's Table of Contents (TOC-Standards, Santé et Génétique chez le Chien-Standards, Health and Genetics in Dogs) is available to DWN guests as well as DWN members. DWN members will have access to all of the book's texts available in DWN's Downloads section. Over the coming year we will feature texts from the book in DWN articles which will be accessible to DWN's members as well as guests. We would like to thank the book's producers and authors for their exceptional knowledge, extraordinary insights and for their willingness to share their expertise with people who are a part of the international dog community.