Reminder: Login to access new features and members-only content!

Register to be a member of our community. Its easy!

Register a new account

Already a member?

Log In here!

Donate

Did you find our content interesting or helpful? Help support the IPFD enhance health, well-being and welfare for dogs everywhere.

Jump to content
  •   Language
  • Sign Up

International Partnership for Dogs - Enhancing Dog Health, Well-Being, and Welfare - Join Us.

Search the Community

Showing results for tags 'brr'.



More search options

  • Search By Tags

    Type tags separated by commas.
  • Search By Author

Content Type


Categories

  • About DogWellNet
    • DogWellNet.com Digest
    • More on DogWellNet.com
    • IPFD News
    • IPFD in the Media
    • More on our Partners and Collaborators
    • Disclaimers & Policies
    • Press
    • IPFD Board
    • About Us
  • Hot Topics
    • Brachycephalics
    • Antimicrobial Resistance / Prudent Use of Antibiotics
  • IPFD International Dog Health Workshops
    • IPFD International Dog Health Workshops - NEWS and Reports
    • IPFD International Dog Health Workshop #4
    • IPFD International Dog Health Workshop #3
    • 2nd International Dog Health Workshop
    • 1st International Dog Health Workshop
  • Health and Breeding
    • Breed-Specific Approaches
    • DogWellNet: Layout and Structure
    • Health and Screening Tests
    • DogWellNet: The Community and Forums
    • Breeding
    • Breeds
  • Population Data on Dogs, Health and Disease
    • Sources of Population Data
    • General Principles
    • Breed Club Health Surveys
    • Disease | Condition-Specific Articles
  • Welfare
    • Welfare and Health
    • Sourcing and Commercial Breeding
    • Dog-Specific Legislation and Programs
    • Human-Dog Interactions
  • Education
    • Education for Judges
    • Education for Youth
    • Education for Veterinary Professionals
    • Education of Consumers and the Public
    • Education of Breeders
  • Research
  • HGTD Quality Database
  • HGTD Genetic Counselling
  • International Actions

Categories

  • Pedigreed Breeds
  • Additional Breed Resources
  • Native Breeds

Categories

  • Overview
    • History and Media Resources
    • IPFD News
  • Who We Are
    • Leadership
    • IPFD Annual Reports
  • Partners and Sponsors
    • Contributing Partners
    • Collaborating Partners
    • Sponsors
  • What We Do
    • DogWellNet.com
    • Harmonization of Genetic Testing for Dogs
    • IPFD International Dog Health Workshops (IDHWs)
  • How We Work
    • The IPFD Approach
    • Policies and Disclaimers
  • Where We Work
  • Get Involved

Categories

  • Quick Start
  • Your Account
  • Navigation
  • Participating in the Community
  • Using the DogWellNet Forums
  • Technical Issues

Categories

  • General
  • IPFD Images for Slider
  • Homepage slider

Blogs

There are no results to display.

There are no results to display.

Categories

  • Regulations
    • Government Regulations
    • Kennel Club Regulations
  • Swedish Insurance Data
  • Swedish Breeding Strategy (RAS) Documents (English Summary)
  • Breed-Specific Documents
  • Welfare and Health
    • Health Conditions
  • Breed Club Health Surveys
  • Breeding
  • Behaviour / Temperament
  • IDHW Files
    • 1st IDHW
    • 2nd IDHW
    • IPFD IDHW #3
    • 4th IDHW
  • Shared Educational and Event Resources
    • General
    • Education of Consumers and Public
    • Education for Breeders
  • Peer Reviewed Research Articles
  • PUBLIC Logos and Style Guides
  • Finnish Breeding Strategy (JTO) documents (English Summary)
  • Norwegian Breeding Strategies - English Summaries
  • The Kennel Club Breed Health Conservation Plan

Product Groups

There are no results to display.

Media Categories

  • IPFD Videos
  • Brachycephalics
  • Behaviour and Training
  • Canine Genetics
  • Health and Welfare

Find results in...

Find results that contain...


Date Created

  • Start

    End


Last Updated

  • Start

    End


Filter by number of...

Joined

  • Start

    End


Group


AIM


MSN


Website URL


ICQ


Yahoo


Jabber


Skype


Region


Location


Country


Current Affiliation


Position / Title


Interests


I am participating in:


Expertise/Proficiencies


Other Information on Interests or Expertise


Specific Breed(s) of Interest


Breed Club Rep; Board Member or Breeding/ Health Committee member


Breed Club / Health Committee Name and URL


Theme attended at 3rd IDHW in Paris

Found 2 results

  1. The continued review of breed-specific tests for assigning relevancy ratings, and ongoing discussions with genetic experts has led to a refinement of the breed relevancy ratings (please see: BRR) . To better accommodate the spectrum of genetic test validation, we’ve added a new orange BRR. The orange BRR indicates where all current available evidence has been reviewed, but the relevancy is inconclusive. It could be that a mutation is detectable in a specific breed, but that there is no evidence that this correlates with clinical development of the disease/phene. It could also be that there is evidence that testing for the mutation does not correlate with the clinical development of the disease. One example is the wire-fox terrier and degenerative myelopathy. Despite research indicating a 94% mutation frequency (Zeng et. al, 2014) - meaning that practically every dog the researchers tested for SOD 1 mutation for degenerative myelopathy had 2 copies of the mutation - the development of the clinical signs of DM for the breed hasn't yet been reported. In practical terms, this means that while you may still wish to test for the mutation in your breed, or it may be included on any testing panels, there isn’t currently a good reason to prioritize test results in any breeding or other health decisions. Unnecessarily excluding a dog from breeding based on irrelevant or inconclusive test results can be, on balance, very damaging to the genetic diversity of the breed. Thinking back to DM and the wire-fox terrier, this would mean that if breeding decisions were made on DM test results alone, you'd be excluding the vast majority of the dog population where the test does not for this breed seem to predict clinical disease. For any orange BRR, it would be worth looking at the test’s breed-specific information in more detail (search for test information HERE) to help put any potential test results into perspective. Wherever possible, the phenes database includes comments directly from the researchers and original test developers. As always, talk to your genetic test provider and/or veterinary scientist if you are concerned about genetic test results. And, if you missed it the first time around, you may want to check out the previous blog including updated breed relevancy ratings, and breed-specific publications, HERE. References: Zeng R., Coates J.R., Johnson G.C., Hansen L., Awano T., Kolicheski A., Ivansson E., Perloski M., Lindblad-Toh K., O'Brien D.P., Guo J., Katz M.L., Johnson G.S. (2014) Breed Distribution of SOD1 Alleles Previously Associated with Canine Degenerative Myelopathy. J Vet Intern Med 28: 515-521 Photo thanks to: Engin Akyurt, via Pexels
  2. HGTD Update: 12 May 2020 Since the last blog, we’ve had additional expert review of many Breed Relevancy Ratings (BRRs) – particular in commonly tested eye conditions, and ataxias. As we are growing our expert out-reach for input into BRRs, we are pleased to note that there is consensus between experts self-reviewing their tests as well as peer-reviewing each other. This adds reassurance to us that the current BRR estimation of combining what we can learn from research publications, phene discoverer’s expert opinions, and informal peer-review between geneticists, is working. So far, we have been able to estimate BRRs for more than 1167+ of the 2684 possible breed-specific test combinations. To support BRRs, we are also adding in additional and newly published breed-specific publications and other references in the Breed Specific Information area of the generic phenes. You can find any breed-specific publications or other resources via the "Search by Test/Disease", under the Researched Breeds section. One example is for Spinocerebellar Ataxia, CAPN1-related – where you can see for 3 breeds, there are links to further information, breeding strategies, and researcher comments and publications: Check out in the HGTD by searching on Ataxia...CAPN1 HERE or go directly to the OUTPUT HERE. Our lists of peer-reviewed publications and referenes are growing by the minute. As a reminder, in the Test/Disease (Phenes) section, you can find the original mutation discovery paper (where known) as well as a selection of other relevant references. As this expands, we are exploring other ways to capture this information to be able to share it in a useful way for you. If you are a researcher, or know of a publication we don’t currently list - especially any breed-specific references, please let us know! We try to include the reference as well as links to open-access resources or a pdf, whenever possible. You can email me at aimee.llewellyn-zaidi@ipfdogs.com Terrier image by P. Kirsi, from Pexels
×
×
  • Create New...

Important Information

By using this site, you agree to our Terms of Use.