Both clinically rare and of complex inheritance. Test is considered poorly correlated with risk for development of DM, and recommendations are to not use the test for breed-wide breeding strategies. While the SOD 1 variant may be commonly found across many breeds, there are few clinical cases observed and confirmed, and in many cases DM has never been observed in the breeds.

Hair length testing has the potential relevance to any dog, but test usage is most often applied to those breeds with a heritage of these traits.

Findings indicate the mutation segregates in a large number of different breeds of dog, many of which are terriers or breeds with terrier co?ancestry, but some of which have more diverse origins. Research indicates that the mutation is present at high frequency within most of the breeds in which it segregates. (Gould et. al, 2011)

Multiple research sources indicate that this form of PRA-prcd could be present in many breeds, and testing could be relevant widely across a large number of different breeds of dog, many of which are terriers or breeds with terrier co?ancestry, but some of which have more diverse origins. Research indicates that the mutation is present at varying breed-specific frequency, but that testing and applying the test results can lead to signifigant reduction in the disease.

Reported in Irish Setter only.