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Brenda’s blog gave a great overview of the American Kennel Club National Parent Club Canine Health Conference we attended earlier this month in St. Louis, Missouri. I am grateful for the sponsorship from the Orthopedic Foundation for Animals provided to myself and the 31 other veterinary students in attendance.
This conference, like the 3rd International Dog Health Workshop, was an opportunity to learn more about cutting edge research that is improving dog health. Topics were varied and included tick borne disease, epilepsy, lymphoma, and reproductive health. It was exciting to see my Colorado State University (CSU) Immunology professor, Dr. Anne Avery, present on her lymphoma research.
Right: View from the top of the St. Louis Gateway Arch
After completing a CSU clinical orthopedics rotation a few weeks prior to the conference, it was especially interesting to hear what I had learned about Omega-3 fatty acids in my rotation be reiterated by presenter Dr. Wendy Baltzer from Massey University. Her Purina funded study described that a diet high in Omega-3 fatty acids post-surgical correction of cranial cruciate ligament disease is helpful and results in less progression of arthritis and lameness.
I’m am looking forward to graduation in 9 months and continued involvement in dog health. The opportunities I have received since first starting my IPFD project have been endless and I am very thankful for the DogWellNet.com community!
Left: Veterinary Student Attendees at the AKC National Parent Club Health Conference
Last weekend I was honored to participate in the 2017 National Parent Club Canine Health Conference presented by the AKC Canine Health Foundation and Nestlé Purina PetCare, in St. Louis, Missouri. It is always great to interact with breeders and club reps that are so committed to the health and welfare of their dogs and their breeds.
This meeting is a mix of breeders (106 parent clubs represented!), vets, and researchers and includes Board members from some of the collaborating organizations who sponsor research, including IPFD Partners and Sponsors: the AKC, the AKC-CHF and the Orthopedic Foundation for Animals (OFA). The OFA sponsored 32 veterinary students to attend the meeting. Our IPFD 2016 Student Kelly Arthur was among the participants!
The research covered a wide array of key topics - from ticks and infectious disease - epilepsy - latest developments in cancer - to issues of reproduction (see list of speakers and topics, below). What an impressive panel of speakers and internationally renowned researchers. It was great to see two of our speakers from the 3rd International Dog Health Workshop, Jason Stull and Rowena Packer, as well as numerous others who participated in that meeting. It certainly feels like the international community of those committed to dog health, well-being and welfare is going strong!
Thanks to the many people who stopped by the IPFD table to talk to us about our organization, DogWellNet.com and especially the Harmonization of Genetic Testing for Dogs initiative (and to grab some chocolate to keep their energy up!). Special thanks to CA Sharpe, from our IPFD Collaborating Partner Australian Shepherd Health & Genetics Institute (ASHGI) for helping me out at the table. It was very gratifying for me to hear someone else talking so enthusiastically about our efforts.
Congrats to AKC-CHF for their continued strength and leadership; for promoting multi-disciplinary interaction; and for an exciting conference.
Attached is the PDF of the slides of my talk (slightly altered, of course) and the abstract.
The 2017 AKC-CHF Conference Program included presentations on the following topics...
- Lymphoma & Epigenetics - Jeffrey Bryan, DVM, PhD, DACVIM-Oncology
- Lymphoma & Flow Cytometry - Anne Avery, VMD, PhD
- Chemotherapy & FortiFlora® - Korinn Saker DVM, PhD, DACVN
- Genetics of Cancer/Lymphoma - Matthew Breen, PhD
- Diet & Rehabilitation - Wendy Baltzer DVM, PhD, DACVS
- Genetic Predisposition to Infections - Urs Giger, DVM, PhD, DACVIM, DECVCP
- Lyme Disease - Jason Stull, VMD, PhD, DACVPM
- Tick-Borne Disease - Ed Breitschwerdt, DVM, DACVIM (*Keynote)
- Ehrlichia & Lymphocytosis - Anne Avery, VMD, PhD
- Canine Cognition - Bill Milgram, PhD
- Genetics of Epilepsy - Gary Johnson, DVM, PhD
- Epilepsy & the Microbiome - Karen Munana, DVM, PhD, DACVIM-Neurology
- Epilepsy & Nutrition - Rowena Packer, PhD
- IPFD: Harmonization of Laboratory Genetic Testing for Dogs - Brenda Bonnett, DVM, PhD
- Semen Evaluation, Quality, and Effects of Aging - Stuart Meyers, DVM, PhD, DACT
- Brucella Update - Angela Arenas, DVM, PhD, DACVP
Pyometra - Marco Coutinho da Silva, DVM, PhD, DACT
New for 2017! Panel discussions with our speakers on:
- Canine Lymphoma
- Tick-Borne Diseases
- Reproductive Diseases
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Well, it's been 10 weeks... and I've learned quite a lot. I hope you have, too! As my project comes to an end, Nina and I wanted to give our viewers a big thank you. I hope you enjoyed this blog series and feel more confident about what your role is in solving antimicrobial resistance (AMR). We would also like to extend a huge thank you to the Skippy Frank Fund who sponsored this entire project, and a thank you to Dr. Jason Stull and Dr. Brenda Bonnett for being wonderful mentors every step of the way.
It is important to keep in mind that science is an ever-changing field that is constantly updated with new material. For example there's a new study that just came out suggesting that not finishing a course of antibiotics may not cause resistance, which is contrary to the current belief. Here is the link to this article if you would like to read more about it. Even though this blog is over, I hope that you continue your AMR education as new scientific data arises.
To complete my summer project, I have constructed a poster that I will be presenting at The Ohio State University College of Veterinary Medicine's Research Day.
Take a look!
Here is the downloadable PDF version:
Be sure to keep checking www.DogWellNet.com for more information on dog health and wellness!
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The Finnish Kennel Club (FKC) has finished the protocol and the instructions for fitness (walk) testing of breeding dogs in brachycephalic breeds. The test is similar to the one used by the Dutch Kennel Club.
Finnish test instructions have been developed by veterinarians doing research on BOAS. Their results concerning the Bulldog have already been published. The researchers are still continuing their research and testing Pugs and French Bulldogs, whose results will be published later.
According to the Finnish guidelines, a dog gets an approved walk test result if he/she walks 1000 meters in 12 minutes or less, and recovers sufficiently from the walk within the recovery time. In the future, it is also possible to have different time limits for different breeds. The test result is failed if
The FKC arranged the first pilot test in February, and the second pilot will be arranged in May. Also orientation for veterinarians will be held at that second pilot. After that, breed clubs are able to arrange the tests by their own. The tests have to be carried out in accordance with the FKC's Guideline for walk tests, in order to get the test result recorded in the FKC breeding database.
The FKC is following the development and use of different tests in other countries. It is also having close collaboration with the other Nordic Kennel Clubs on this subject. The aim is, in the long run, and with the help of accumulated experience, to develop the test further, to be as appropriate as possible.
All the information on the Finnish walk test can be found here.
Published a few months ago, a study of Marsden et al. (2016) used whole sequence data of 90 canids to investigate the importance of population bottleneck, inbreeding and artificial selection of the health of the dog.
In order to investigate this issue, the authors compared sequences from breed dogs, village dogs, and gray wolves, measuring (i) the proportion of amino acid changing variants, as an indicator of genetic load, and (ii) the number of Mendelian disease genes, considering genes already identified in dogs and human. Several interesting results were found.
Based on their measurement of amino acid changing variants (corresponding in general to mutations with deleterious effects), it has been estimated that dogs carry between 2 and 3% more deleterious alleles than wolves, which is comparable to the genetic load in the non-African human population (around 1-3%). This seems surprising, as dog breeds may appear to have undergone more severe bottlenecks during their demographic history than human populations. Also, the authors found that bottlenecks during domestication and breed creation were more responsible of the current genetic load in dogs than recent inbreeding.
On the other hand, it appears that genomic regions under selection (also called selective sweeps), were enriched in disease-related genes. This enrichment could be either explained by the fact that genes controlling artificially selected traits in dogs could also confer Mendelian diseases, or to a linkage between genomic regions where disease genes and genes under selection are.
On the basis on these different results, the authors concluded that artificial selection incidentally reduced dog fitness. Also, given the fact that repeated population bottlenecks and small effective population size seemed to have more impact on accumulation of weakly deleterious variation than recent inbreeding (i.e., mating between close relatives), the focus should be more on maintaining large population size, than avoiding inbreeding.
Given the number of studies that showing the impact of recent inbreeding of fitness and selected traits in dog (Ólafsdóttir and Kristjánsson, 2008; Urfer, 2009, Leroy et al. 2014) or other domestic species (Leroy 2014), I would nevertheless disagree with this last recommendation. It would be therefore be interesting to investigate why the results of this genomic study differ from more phenotype-oriented ones. There are several potential explanations, one being that the traits investigated in those latter studies are under different genetic mechanisms that the one studied here. In any case, we may expect that further studies will confirm, refute or further clarify these first interesting results.
Leroy, G. 2014. Inbreeding depression in livestock species: review and meta-analysis. Animal Genetics 189, 177-182.
Leroy G., Phocas F., Hedan B., Verrier E., Rognon X. 2015. Inbreeding impact on litter size and survival in selected canine breeds. The Veterinary Journal.
Marsden, C. D., Ortega-Del Vecchyo, D., O’Brien, D. P., Taylor, J. F., Ramirez, O., Vilà, C., ... & Lohmueller, K. E. 2016. Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs.Proceedings of the National Academy of Sciences, 113(1), 152-157.
Ólafsdóttir, G.Á., Kristjánsson, T., 2008. Correlated pedigree and molecular estimates of inbreeding and their ability to detect inbreeding depression in the Icelandic sheepdog, a recently bottlenecked population of domestic dogs. Conservation Genetics 9, 1639-1641.
Urfer, S.R., 2009. Inbreeding and fertility in Irish Wolfhounds in Sweden: 1976 to 2007. Acta Veterinaria Scandinavica 51, 21.
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IPFD Board Member Dr. Patricia Olson was the keynote speaker at the Inaugural One Health Program at Midwestern University on October 8, 2015 (Downer’s Grove, Illinois).
Midwestern University also has one of the newest veterinary schools in the U.S. (Phoenix, Arizona). Physicians were paired with veterinarians to deliver lectures on obesity, pneumonia, osteochondritis dissecans and epilepsy. Dr. Olson’s lecture was on collaborative research, using the clues from animals to help advance both human and animal health/welfare.
See the pdf of her thought-provoking talk here:
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Once a year, in October, the SKK Breeding Committee organizes a weekend course for
breeding officials based on the book Dog breeding in theory and practice by Sofia Malm (SKK genetic expert) and Åsa Lindholm.
The Genetic Expert and The Breeding Consultant of the SKK Department for Breeding and Health are in charge of the course.
The aim is to give breed clubs education and tools they need to work with breeding plans and breed-specific strategies.
The contents of the course include basic genetics and guidance in how to conduct work at club level.
There’s also a certain amount of self-directed studies.
Every other year, in April, this education is held specifically directed to hunting dog breed clubs.
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On the podium:
1st : Meisterhaus Signet Higher'N Higer ; Breed: Basenji ; Owner: Lise DURLOT and Dimitri HEBERT ; Breeder: Brenda CASSELL and Tad BOOKS
2nd : Fall In Love Forest Ohara Of Bloom White ; Breed : Samoyede ; Owner: Mira MITKOVA ; Breeder: Elisabeth FAUCON
3rd : Eternal Drago Of Nordic Forest ; Breed : Siberian Husky ; Owner and breeder: Valérie CHARNEAU
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In June of 2014, the OFA Board of Directors voted unanimously to become a founding member of the International Partnership for Dogs (IPFD). With the majority of the founding members made up of national kennel clubs, the OFA is somewhat unique as a non-profit foundation. So why the decision to support the IPFD as a founding member?
Overwhelmingly, it was the commonality in the two organizations’ missions, and the belief that the OFA could both contribute to and benefit from the collaboration.
The mission of the OFA is “to improve the health and well-being of companion animals through a reduction in the incidence of genetic disease.” The OFA achieves its mission through four specific objectives:
- To collate and disseminate information concerning orthopedic and genetic diseases of animals.
- To advise, encourage and establish control programs to lower the incidence of orthopedic and genetic diseases.
- To encourage and finance research in orthopedic and genetic disease in animals.
- To receive funds and make grants to carry out these objectives.
The mission of the IPFD is to facilitate collaboration and sharing of resources to enhance the health, well-being and welfare of pedigreed dogs and all dogs worldwide.
Most individuals involved in canine health understand that our issues are not constrained by borders. Internationally, we face the same challenges, whether breed specific health improvement strategies, discussions regarding phenotypic extremes, debates on genetic diversity within closed populations, harmonization of various health screening protocols, validation of genetic tests and laboratories, or the host of regulations which can impact dog breeders and animal welfare both positively and negatively.
The OFA believes the IPFD and the new DogWellNet.com platform provides the first and best opportunity to advance early international discussions to a plan of action. We are pleased to be involved with the IPFD at its inception, look forward to working with the other members, and mostly look forward to our combined efforts leading to healthier dogs tomorrow.