BRR applies to standard poodle crosses origin

BRR applies to cocker crosses

Multiple research sources indicate that this form of PRA-prcd could be present in many breeds, and testing could be relevant widely across a large number of different breeds of dog, many of which are terriers or breeds with terrier co?ancestry, but some of which have more diverse origins. Research indicates that the mutation is present at varying breed-specific frequency, but that testing and applying the test results can lead to signifigant reduction in the disease.

Both clinically rare and of complex inheritance. Test is considered poorly correlated with risk for development of DM, and recommendations are to not use the test for breed-wide breeding strategies. While the SOD 1 variant may be commonly found across many breeds, there are few clinical cases observed and confirmed, and in many cases DM has never been observed in the breeds.

The mutation associated with EIC has been identified in a number of breeds - particularly hunting/working breeds. As the EIC phenotype requires an environmental stimulus in most cases, it should be noted that dogs could be genetically affected for EIC without displaying the condition. It may be valuable to breeders of those breeds where the mutation has been detected to use a genetic test, where breed-specific research is ongoing.