Autoinflammatory diseases in dogs are characterized by complex disease processes with varying clinical signs. In Shar-Pei, signs of inflammation including fever and arthritis are known to be related with a breed-specific predisposition for Shar-Pei Autoinflammatory Disease (SPAID)...Clinical and histopathological examinations of two severely SPAID-affected Shar-Pei revealed signs of inflammation including fever, arthritis, and perivascular and diffuse dermatitis in both dogs. A multifocal accumulation of amyloid in different organs was found in one SPAID-affected case... Shar-Pei with a heterozygous genotype (G/A) were shown to have a 2.13-fold higher risk for disease development, which gave evidence for an incomplete dominant mode of inheritance. (From Metzger et al, 2017)

Familial Shar-Pei Fever (FSF) causes dogs to be in a constant state of inflammation. Symptoms include fever - which can reach over 106F and require emergency treatment, pain, joint swelling, enlarged and swollen muzzle, swollen lips, vomiting, diarrhea. Age of onset starting from 18 months, but can occur in adulthood. May lead to Amyloidosis increaseing the risk of kidney failure.