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Progressive Retinal Atrophy, GR PRA2
Progressive Retinal Atrophy, GR PRA2
  Discussion

This form of PRA for the Golden Retriever is one of several that can be tested for. The signs of GR PRA1 are typical of the late-onset forms of the disease. Age of diagnosis is most often around 5 years, but there is variation across the breed. Dogs typically experience night blindness leading to reduced sight even in bright conditions. There are known to be more than one gene mutations that cause PRA(prcd) in the Golden Retriever. Any test for GR PRA 2 can only confirm for the mutation, or not, in this specific form.

Most PRA cases in the Golden Retriever (GR) are clinically indistinguishable from other forms of PRA. The mode of inheritance appears from pedigree information to be autosomal recessive. While the age of diagnosis is most commonly at a relatively late age of approximately 5 years there is a great deal of variation within the breed. There are known to be more than one gene mutations that cause PRA(prcd) in the Golden Retriever.

  Genetics
Inheritance
AR
OMIA
001984
OMIA Variant
200610
OMIA URL
https://www.omia.org/OMIA001984/9615/
OMIN
TTC8
Gene
Variants
g.60090186del, c.669delA, p.(K223Rfs*15
Variants Comments
  Testing
Test Types
Physical
Genetic-Genomic
Assessments
Specific Genetic Test
Assays
Direct Mutation
Connections
  • Updated
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