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Cerebellar Ataxia
Ataxia, Cerebellar, Progressive Early-onset, SEL1L-related, Neuroaxonal dystrophy
Cerebellar Ataxia
  Discussion

Breed Specific: There is currently no specific research paper for the Finnish Hound, but supportive evidence indicates the genetic test may be relevant. (2025)

Clinical Comments: This form of ataxia is characterized by being an early-onset, progressive disease resulting in a lack of coordination, difficulty balancing and walking, and tremor. Clinical signs were present by the age of 3 months, and cerebellar shrinkage was detectable through MRI. Progression is fast, with some dogs being euthanized before 6 months of age.

Veterinary Comments: Inherited ataxias are characterized by degeneration of the cerebellar structures, which results in progressive motor incoordination... The Finnish Hound suffers from an early-onset progressive cerebellar ataxia... Neurological examinations on ten affected dogs revealed rapidly progressing generalized cerebellar ataxia, tremors, and failure to thrive. Clinical signs were present by the age of 3 months, and cerebellar shrinkage was detectable through MRI. Pathological and histological examinations indicated cerebellum-restricted neurodegeneration. (Kyostila et al, 2012)

  Genetics
Inheritance
AR
OMIA
001692
OMIA Variant
000028
OMIA URL
https://omia.org/OMIA001692/9615/
OMIN
Gene
SEL1
Variants
g.53778458A>G; c.1972T>C; p.(S658P)
Variants Comments
  Testing
Test Types
Genetic-Genomic
Assessments
Specific Genetic Test
Assays
dwn_cnd_
Connections
  • Updated
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