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Inbreeding Calculators — How They Work and What They Tell Us


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About This File

Author: Bert Klei, Ph.D.
University of PIttsburgh Medical Center

 

This article specifically applies to Bernese Mountain Dogs | The Berner-Garde Database COI calculator; however, the article does provide discussion and general information on use of COI, and COI calculators.

 

Excerpt...
"An inbreeding calculator determines the COI. In genetic terms this is the probability that the two alleles at a locus are identical by descent. In practice people think about this as the chance that the two copies of a gene come from a single copy of a gene from a single ancestor. When breeders talk about "doubling up" on traits, this is to what they are referring."


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    • A Continuing and Sustainable Development The International Partnership for Dogs (IPFD) and DogWellNet.com have come into being following a long history of efforts by many stakeholders to address dog health and well-being. An abbreviated timeline of key developments will highlight the complexity of issues addressed by the IPFD and DogWellNet and will list some of the many supporters and collaborators that have contributed directly or indirectly to this important work. Development was inaugurated under the patronage of the Fédération Cynologique Internationale (FCI). The major contributors (in-kind and funding) since 2011 have been, chronologically, the Agria Animal Insurance
    • We're Genoscoper - the specialists in canine genetics and animal DNA testing. We offer solutions to help you make informed decisions about pet care and breeding, through comprehensive testing services and improved DNA diagnostics, with the most advanced BioIT.     Genoscoper is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.      
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    • See the September 2016 IPFD Presentation to the Kennel Club's Breed Health Coordinators 2.45 MB · 0 downloads IPFD_Presentation to KC BHCs Sept 2016_post meeting notes_for DWN-web.pdf   Are you involved in a dog club for your breed? Would you like to share information from your kennel club, breed club or country with DogWellNet.com? Already a DogWellNet.com Member?  Sign In, make sure your profile is up-to-date and see Next Steps, below. Visiting us as a guest? Sign Up to participate. Sign Up is open to the public and new participants automatically become  DogWellnet.com Members Members of DogWellNet have access to content including ou
    • Neogen Genomics operations deliver innovative, affordable DNA testing for the discovery and commercial application of genomic advances that enhance the safety and abundance of life.   Neogen Genomics is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.            
    • Agria is one of the world’s leading animal insurers, specialising in small animal and equine insurance. Founded in Sweden over 120 years ago, Agria came to the UK in 2009 and is now a prominent feature of the UK pet insurance industry. In the UK, Agria insures cats, dogs and rabbits.
    • The VDH - Verband für das Deutsche Hundewesen (German Kennel Club in English) is the foremost organisation representing the interests of dog owners throughout Germany – the first address to find out everything there is to know on the subject of life with dogs, on dog sports and on dog breeding. As an umbrella organisation for its 175 member clubs, the VDH today represents more than 650,000 members.   Website: http://www.vdh.de/en/home/ Registration Statistics: https://www.vdh.de/ueber-den-vdh/welpenstatistik/ An overview of the VDH (in German) can be found here.    "The VDH is the leading advocacy of all dog owners in Germany - the primary authority on life with d
    • Mars Veterinary is a business unit of Mars Petcare, the world’s largest pet care provider. Their mission is to facilitate responsible pet care by enhancing the well-being and relationship between pets, pet owners, breeders, shelters and veterinarians through valuable insights into pets as individuals.   Mars Veterinary is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.            
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    • The World Small Animal Veterinary Association (WSAVA) is an association of associations. Its membership is made up of veterinary organisations from all over the world, which are concerned with companion animals.     The Hereditary Diseases Committee of the WSAVA is collaborating on the IPFD Harmonization of Genetic Testing for Dogs initiative.   Website: www.wsava.org    
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    • Online Mendelian Inheritance in Animals (OMIA) is an online database, freely available to anyone in the world, created and curated in the Sydney School of Veterinary Science, within the University of Sydney, by Emeritus Professor Frank Nicholas, assisted by local and international colleagues.
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    • ANTAGENE develops, produces and markets DNA tests for parentage certification and disease prevention in dogs and cats. The company is based near Lyon (France) and has a staff of 18 people. ANTAGENE offers more than 100 DNA tests in some 50 countries around the world. ANTAGENE solutions have been used by more than 80,000 breeders and veterinarians the world over.   . ANTAGENE was an initiating sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.    
    • At Paw Print Genetics, our geneticists and veterinarians are committed to provide you and your dog unparalleled service with our large menu of tests, online account management and the highest accuracy in the industry.   Paw Print Genetics is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs initiative.        
    • Around the world many people regard their pets as family members, and we want to help provide the best possible care for them. Screening can help identify the cause of a current problem as well as reduce the risk of future conditions to increase the health of future generations. Animal Genetics offers customers throughout the world a large number of tests for canine hereditary diseases, traits including color and parentage verification.     Animal Genetics is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.      
    • IPFD is a truly "people driven" service organization. Our structure and resources (a modest budget and small group of consultants, volunteers, and Board Members) facilitate the activities of our stakeholders to achieve our individual and collective priorities for the health and welfare of dogs. As a growing, independent voice within the global dog community, we aim to provide the best possible information and advice to assist our stakeholders in making optimal decisions for their members, customers, and breed(s) of interest. IPFD provides and supports a ‘big picture’, balanced, transparent and integrated approach to the complex challenges for dogs and the people who care about them.
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