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About This File

Oculoskeletal dysplasia

Canine genetics research at the Animal Health Trust
• Basic genetics
• Finding disease mutations
• Genetics of OSD – Part 1 –
        Identifying the causal mutation
• Genetics of OSD – Part 2 –
       Implications for the breed
• Summary and Breeding Advice
• Acknowledgements
• OSD3 DNA Test

Breeds information/impacts...

- the drd1 mutation in the gene COL9A3 in the Labrador retriever
- the drd2 mutation in the gene COL9A2 in the Samoyed - autosomal recessive mode of inheritance of the complete phenotype

• Clinical findings in the Labrador retriever & in the Samoyed
  (Carrig et al. 1988 & Goldstein et al. 2010)
- disproportionate dwarfism
- corneal opacities, cataracts, persistent hyaloid artery remnants, vitreal dysplasia, alterations in optic nerve head colour + size, retinal dysplasia retinal detachment
• Recently observed in 7 Northern Inuit Dogs (NID)

 


  • International Dog Health Workshops

    Decision leaders from major stakeholders moving from information to action.

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    Post-Meeting Resources
    Plenary talks, Posters & outcomes

  • Our Partners

    • Raad van Beheer (The Dutch Kennel Club (DKC)) is the official kennel club of The Netherlands. Founded in 1902, it currently represents around 200 breed clubs with 150,000 members.   The DKC is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.      
    • The Norwegian Kennel Club (NKC) was founded in 1898, and is the largest organisation for dog owners in Norway. Website: https://www.nkk.no/english/category1045.html Norwegian Kennel Club Blog at DogWellNet: - under construction -
    • Our mission is to safeguard the health and wellbeing of your pet with fully personalised, breed-specific care. Orivet was founded on the premise that each and every pet is unique, with its own set of specific traits, behaviours, genetic health needs and inherent risks. We work with pet owners, breeders and vets to provide completely personalised products and services that treat and care for pets as the unique individuals they are, taking into account each pet’s genetic makeup, age, sex and lifestyle.   Through this we aim to encourage the development of a deep, genuine and lasting bond between pets and their owners.   Orivet is a proud sponsor of IPFD's Harmonizatio
    • Around the world many people regard their pets as family members, and we want to help provide the best possible care for them. Screening can help identify the cause of a current problem as well as reduce the risk of future conditions to increase the health of future generations. Animal Genetics offers customers throughout the world a large number of tests for canine hereditary diseases, traits including color and parentage verification.     Animal Genetics is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.      
    • CAG GmbH makes it easy to secure the genetic health of your four-legged friends. We provide the tools you need: a comprehensive offering of genetic tests, quick turn-around in the in-house accredited laboratory, and personal counseling to help you understand what the results really mean for you and your animal. With state-of-the-art technology, a robust R&D program, and dedicated specialists in animal genetics, CAG works with you to ensure the health and happiness of your best friend.     CAG GmbH is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.          
    • Mars Veterinary is a business unit of Mars Petcare, the world’s largest pet care provider. Their mission is to facilitate responsible pet care by enhancing the well-being and relationship between pets, pet owners, breeders, shelters and veterinarians through valuable insights into pets as individuals.   Mars Veterinary is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.            
    • Sentinel Biomedical is a pioneering comparative health company committed to research and scientific innovation. The company’s primary focus is investigating canine cancers and identifying biological changes and environmental influences that may be shared with human cancers, making canines true watchdogs in the area of human health.   Sentinel Biomedical is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.      
    • The European School for Advanced Veterinary Studies (ESAVS) is a non for profit organization registered in Luxemburg dedicated to the advancement of veterinary medicine for companion animals. ESAVS was founded in 1991 as a project in the frame of the European Union‘s COMETT II and LEONARDO DA VINCI programs. It is affiliated with the Faculty of Science, Technology and Communication at the University of Luxembourg.  
    • Website: http://www.akc.org
    • The French Kennel Club - SOCIÉTÉ CENTRALE CANINE (SCC) - was founded in 1881 as a non-profit organization by dog fanciers aiming to replenish native dog breeds and to bring in and establish foreign ones as well. The Société Centrale Canine became soon the reference canine organization, being recognized as a public interest organization by decree of the Council of State in April 1914. The SCC is proud to be one of the founders of the FCI in 1911, together with the Kennel Clubs from Germany, Austria, Belgium and the Netherlands.   Website: https://www.centrale-canine.fr/ Follow this link for the French Kennel Club Blog at DogWellNet
    • VetCompass shares and analyses veterinary clinical information to understand the disorders and improve the welfare of companion animals. Effective systems for the generation, sharing and application of reliable evidence are critical to improve the health of dogs. VetCompass is delighted to formally support and collaborate with the IPFD and DogWellNet which are critical elements in the international effort to better understand and enhance the lives of dogs worldwide.
    • IPFD logos, annual reports, and other resources for use by the media are available here.
    • The Genomia laboratory is a private accredited genetic laboratory in Pilsen, Czech Republic. Genomia is engaged in genetic testing of humans, animals and pathogens. In humans, we are testing relationships between relatives – paternity and genealogy. For animals, we offer more than 150 tests for hereditary diseases, sex determination, parenthood determination and tests for coat appearance and colour. Genomia offers services to customers all over the world. Genomia cooperates with breeders from more than 38 countries on four continents.     Genomia is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.        
    • Royal Canin is a global leader in pet health nutrition. In an industry that continues to adapt to popular trends in cat and dog food, our mission will remain the same; to constantly bring, through Health Nutrition and shared knowledge, the most precise nutritional solution for cats' and dogs' health nutrition needs, by building on constantly deepened scientific knowledge and Royal Canin's roots in the feline and canine professional networks.
    • Mars Veterinary is a business unit of Mars Petcare, the world’s largest pet care provider. Their mission is to facilitate responsible pet care by enhancing the well-being and relationship between pets, pet owners, breeders, shelters and veterinarians through valuable insights into pets as individuals.   Mars Veterinary is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.          
    • At Paw Print Genetics, our geneticists and veterinarians are committed to provide you and your dog unparalleled service with our large menu of tests, online account management and the highest accuracy in the industry.   Paw Print Genetics is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs initiative.        
    • FECAVA is the platform for the promotion of professional development and the representation of companion animal veterinarians in Europe. FECAVA strives to improve the veterinary care of pets, to highlight the human-animal bond and the ‘One Health’ concept. It does this through professional development and liaisons with relevant organisations and stakeholders and by facilitating the interaction between European companion animal veterinarians.
    • IPFD is a truly "people driven" service organization. Our structure and resources (a modest budget and small group of consultants, volunteers, and Board Members) facilitate the activities of our stakeholders to achieve our individual and collective priorities for the health and welfare of dogs. As a growing, independent voice within the global dog community, we aim to provide the best possible information and advice to assist our stakeholders in making optimal decisions for their members, customers, and breed(s) of interest. IPFD provides and supports a ‘big picture’, balanced, transparent and integrated approach to the complex challenges for dogs and the people who care about them.
    • IPFD At-a-Glance: Non-profit, registered in Sweden Independent, international, multi-stakeholder, multi-disciplinary Facilitates collaboration and sharing of information and bringing the dog world together for action to enhance dog health, well-being, and welfare. Our Partners and Collaborators are organizations that share our interest in dog health, well-being, and welfare. Our Founding Partners were national kennel clubs, international cynological organizations, and from pet industries; our collaborating partners include groups from academic institutions, breed specific interests, educational and professional organizations (include both for profit and non-profi
    • Mission Facilitate collaboration and sharing of resources to enhance the health, well-being and welfare of pedigreed dogs and all dogs worldwide. Vision An enduring global collaboration enhancing dog health, well-being and welfare, and human-dog interactions. Values Dog health, well-being and welfare and human-dog interactions contribute to the quality of life for both species. The world is a better place because we share it with dogs. Dog issues are important around the globe and international sharing and cooperation is needed. Goals The general goals of the IPFD are to:  Enhance the health, well-being and welfare of dogs and enr
    • The Dog Breeding Reform Group (DBRG) is an organisation dedicated to improving the health and welfare of dogs through responsible breeding. It was founded in 2013 and became a Charitable Trust in 2015. Members of the DBRG include veterinary specialists, dog welfare and law experts, breeders and dog owners.
    • The SKK - Svenka Kennelklubben (Swedish Kennel Club, in English), is Sweden's largest organisation dedicated to dogs and dog owners. We represent the interests of our 300,000 members – first time dog owners, experienced breeders, hunters, dog lovers, puppy buyers, exhibitors, agility competitors and many more.   Website: http://www.skk.se/en/ Follow this link for the SKK Blog at DogWellNet Follow this link for more information on the Swedish Kennel Club including our organizational structure, code of ethics, and more.
  • Pedigreed Breeds

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