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The Genetics Behind OSD 1.0.0


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About This File

Oculoskeletal dysplasia

Canine genetics research at the Animal Health Trust
• Basic genetics
• Finding disease mutations
• Genetics of OSD – Part 1 –
        Identifying the causal mutation
• Genetics of OSD – Part 2 –
       Implications for the breed
• Summary and Breeding Advice
• Acknowledgements
• OSD3 DNA Test

Breeds information/impacts...

- the drd1 mutation in the gene COL9A3 in the Labrador retriever
- the drd2 mutation in the gene COL9A2 in the Samoyed - autosomal recessive mode of inheritance of the complete phenotype

• Clinical findings in the Labrador retriever & in the Samoyed
  (Carrig et al. 1988 & Goldstein et al. 2010)
- disproportionate dwarfism
- corneal opacities, cataracts, persistent hyaloid artery remnants, vitreal dysplasia, alterations in optic nerve head colour + size, retinal dysplasia retinal detachment
• Recently observed in 7 Northern Inuit Dogs (NID)

 

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  • International Dog Health Workshops

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  • Our Partners

    • Canine Medicine and Genetics is a peer-reviewed, open access journal addressing genetic, genomic and epidemiological research in both domestic and wild canids, relating to breed and species diversity, and canine evolution.  
    • Mars Veterinary is a business unit of Mars Petcare, the world’s largest pet care provider. Their mission is to facilitate responsible pet care by enhancing the well-being and relationship between pets, pet owners, breeders, shelters and veterinarians through valuable insights into pets as individuals.   Mars Veterinary is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.          
    • The European School for Advanced Veterinary Studies (ESAVS) is a non for profit organization registered in Luxemburg dedicated to the advancement of veterinary medicine for companion animals. ESAVS was founded in 1991 as a project in the frame of the European Union‘s COMETT II and LEONARDO DA VINCI programs. It is affiliated with the Faculty of Science, Technology and Communication at the University of Luxembourg.  
    • CAG GmbH makes it easy to secure the genetic health of your four-legged friends. We provide the tools you need: a comprehensive offering of genetic tests, quick turn-around in the in-house accredited laboratory, and personal counseling to help you understand what the results really mean for you and your animal. With state-of-the-art technology, a robust R&D program, and dedicated specialists in animal genetics, CAG works with you to ensure the health and happiness of your best friend.     CAG GmbH is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.          
    • Our laboratory provides a complete testing service for veterinary surgeons to meet the diagnostic needs of your practice.     LABOKLIN is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.      
    • IPFD logos, annual reports, and other resources for use by the media are available here.
    • This year has been challenging for all organizations globally.  However, IPFD has fared well.  We have always been a ‘virtual’-based operation, with all consultants working from home.  Building on our 2019 Annual Report: A Growing Voice, this milestones document is meant to update our Partners and Sponsors on our activities in 2020. – Dr. Brenda Bonnett, CEO (click to download/share as a PDF): IPFD Milestones December 2020.pdf   Message from the Canadian Kennel Club: “CKC’s membership in the International Partnership for Dogs, and participation in the biennial Dog Health Workshop and the international working group for extremes in conformation has strengthened
    • See the September 2016 IPFD Presentation to the Kennel Club's Breed Health Coordinators 2.45 MB · 0 downloads IPFD_Presentation to KC BHCs Sept 2016_post meeting notes_for DWN-web.pdf   Are you involved in a dog club for your breed? Would you like to share information from your kennel club, breed club or country with DogWellNet.com? Already a DogWellNet.com Member?  Sign In, make sure your profile is up-to-date and see Next Steps, below. Visiting us as a guest? Sign Up to participate. Sign Up is open to the public and new participants automatically become  DogWellnet.com Members Members of DogWellNet have access to content including ou
    • VetCompass shares and analyses veterinary clinical information to understand the disorders and improve the welfare of companion animals. Effective systems for the generation, sharing and application of reliable evidence are critical to improve the health of dogs. VetCompass is delighted to formally support and collaborate with the IPFD and DogWellNet which are critical elements in the international effort to better understand and enhance the lives of dogs worldwide.
    • The Irish Kennel Club promotes the responsible ownership and breeding of dogs throughout Ireland through education, registration, training and support schemes and events.   Website: http://www.ikc.ie/ Irish Kennel Club Blog at DogWellNet: - under construction -
    • The Black Russian Terrier Club of America (BRTCA) is the AKC Parent Club for the Black Russian Terrier. BRTCA's mission is to do all in its power to protect and advance the interests of the breed and to encourage sportsmanlike competition at conformation shows, companion events and performance trials.    
    • IPFD is a truly "people driven" service organization. Our structure and resources (a modest budget and small group of consultants, volunteers, and Board Members) facilitate the activities of our stakeholders to achieve our individual and collective priorities for the health and welfare of dogs. As a growing, independent voice within the global dog community, we aim to provide the best possible information and advice to assist our stakeholders in making optimal decisions for their members, customers, and breed(s) of interest. IPFD provides and supports a ‘big picture’, balanced, transparent and integrated approach to the complex challenges for dogs and the people who care about them.
    • The French Kennel Club - SOCIÉTÉ CENTRALE CANINE (SCC) - was founded in 1881 as a non-profit organization by dog fanciers aiming to replenish native dog breeds and to bring in and establish foreign ones as well. The Société Centrale Canine became soon the reference canine organization, being recognized as a public interest organization by decree of the Council of State in April 1914. The SCC is proud to be one of the founders of the FCI in 1911, together with the Kennel Clubs from Germany, Austria, Belgium and the Netherlands.   Website: https://www.centrale-canine.fr/ Follow this link for the French Kennel Club Blog at DogWellNet
    • The Kennel Club is the largest organization in the UK devoted to dog health, welfare and training. Its objective is to ensure that dogs live healthy, happy lives with responsible owners.   Website: http://www.thekennelclub.org.uk  
    • Vetstream Ltd  (www.vetstream.net) offers TLC for veterinary practices so they can provide TLC for their clients and their companion and production animals.   Vetstream is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.    
    • Royal Canin is a global leader in pet health nutrition. In an industry that continues to adapt to popular trends in cat and dog food, our mission will remain the same; to constantly bring, through Health Nutrition and shared knowledge, the most precise nutritional solution for cats' and dogs' health nutrition needs, by building on constantly deepened scientific knowledge and Royal Canin's roots in the feline and canine professional networks.
    • Agria is one of the world’s leading animal insurers, specialising in small animal and equine insurance. Founded in Sweden over 120 years ago, Agria came to the UK in 2009 and is now a prominent feature of the UK pet insurance industry. In the UK, Agria insures cats, dogs and rabbits.
    • Mission Facilitate collaboration and sharing of resources to enhance the health, well-being and welfare of pedigree dogs and all dogs worldwide. Vision An enduring global collaboration enhancing dog health, well-being and welfare, and human-dog interactions. Values Dog health, well-being and welfare and human-dog interactions contribute to the quality of life for both species. The world is a better place because we share it with dogs. Dog issues are important around the globe and international sharing and cooperation is needed. Goals The general goals of the IPFD are to:  Enhance the health, well-being and welfare of dogs and enri
    • "ASHGI is dedicated to the increase and diffusion of knowledge of genetics in the Australian Shepherd, and the inherited diseases from which it sometimes suffers. We envision serving all Aussies, no matter what their purpose, the goals of their owners, or where they live. ASHGI will work both independently and in cooperation with researchers, breed clubs, canine health organizations and foundations that provide grant funds for canine genetics research."  
    • The Genomia laboratory is a private accredited genetic laboratory in Pilsen, Czech Republic. Genomia is engaged in genetic testing of humans, animals and pathogens. In humans, we are testing relationships between relatives – paternity and genealogy. For animals, we offer more than 150 tests for hereditary diseases, sex determination, parenthood determination and tests for coat appearance and colour. Genomia offers services to customers all over the world. Genomia cooperates with breeders from more than 38 countries on four continents.     Genomia is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.        
    • The World Small Animal Veterinary Association (WSAVA) is an association of associations. Its membership is made up of veterinary organisations from all over the world, which are concerned with companion animals.     The Hereditary Diseases Committee of the WSAVA is collaborating on the IPFD Harmonization of Genetic Testing for Dogs initiative.   Website: www.wsava.org    
    • FECAVA is the platform for the promotion of professional development and the representation of companion animal veterinarians in Europe. FECAVA strives to improve the veterinary care of pets, to highlight the human-animal bond and the ‘One Health’ concept. It does this through professional development and liaisons with relevant organisations and stakeholders and by facilitating the interaction between European companion animal veterinarians.
    • The Canadian Kennel Club (CKC) is the primary registry body for purebred dogs in Canada and currently recognizes 175 breeds. As a non-profit organization, the CKC is dedicated to encouraging, guiding, and advancing the interests of purebred dogs and their responsible owners and breeders in Canada and promoting the knowledge and understanding of the benefits which dogs can bring to Canadian society.  
    • A Continuing and Sustainable Development The International Partnership for Dogs (IPFD) and DogWellNet.com have come into being following a long history of efforts by many stakeholders to address dog health and well-being. An abbreviated timeline of key developments will highlight the complexity of issues addressed by the IPFD and DogWellNet and will list some of the many supporters and collaborators that have contributed directly or indirectly to this important work. Development was inaugurated under the patronage of the Fédération Cynologique Internationale (FCI). The major contributors (in-kind and funding) since 2011 have been, chronologically, the Agria Animal Insurance
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