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About This File

Oculoskeletal dysplasia

Canine genetics research at the Animal Health Trust
• Basic genetics
• Finding disease mutations
• Genetics of OSD – Part 1 –
        Identifying the causal mutation
• Genetics of OSD – Part 2 –
       Implications for the breed
• Summary and Breeding Advice
• Acknowledgements
• OSD3 DNA Test

Breeds information/impacts...

- the drd1 mutation in the gene COL9A3 in the Labrador retriever
- the drd2 mutation in the gene COL9A2 in the Samoyed - autosomal recessive mode of inheritance of the complete phenotype

• Clinical findings in the Labrador retriever & in the Samoyed
  (Carrig et al. 1988 & Goldstein et al. 2010)
- disproportionate dwarfism
- corneal opacities, cataracts, persistent hyaloid artery remnants, vitreal dysplasia, alterations in optic nerve head colour + size, retinal dysplasia retinal detachment
• Recently observed in 7 Northern Inuit Dogs (NID)

 


  • International Dog Health Workshops

    Decision leaders from major stakeholders moving from information to action.

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    Post-Meeting Resources
    Plenary talks, Posters & outcomes

  • Our Partners

    • Around the world many people regard their pets as family members, and we want to help provide the best possible care for them. Screening can help identify the cause of a current problem as well as reduce the risk of future conditions to increase the health of future generations. Animal Genetics offers customers throughout the world a large number of tests for canine hereditary diseases, traits including color and parentage verification.     Animal Genetics is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.      
    • Suomen Kennelliitto (Finnish Kennel Club, in English) - Established in 1889, the Finnish Kennel Club is a nationwide expert organisation on canine matters. Its aim is to promote the breeding of pedigree dogs, support diverse dog-related activities and improve dog-keeping standards in Finland. FKC disseminates expert information and serves as a comprehensive lobbying organisation for Finnish and international dog activities.   Website: https://www.kennelliitto.fi/en FKC Database: KoiraNet-jalostustietojärjestelmä: https://jalostus.kennelliitto.fi/ PEVISA: https://www.kennelliitto.fi/kasvatus-ja-terveys/pentueen-rekisterointi/kaikkia-rotuja-koskevat-rekisterointiehdot-pevisa-j
    • IPFD logos, annual reports, and other resources for use by the media are available here.
    • Canine Medicine and Genetics is a peer-reviewed, open access journal addressing genetic, genomic and epidemiological research in both domestic and wild canids, relating to breed and species diversity, and canine evolution.  
    • Raad van Beheer (The Dutch Kennel Club (DKC)) is the official kennel club of The Netherlands. Founded in 1902, it currently represents around 200 breed clubs with 150,000 members.   Raad van Beheer is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.      
    • The Norwegian Kennel Club (NKC) was founded in 1898, and is the largest organisation for dog owners in Norway. Website: https://www.nkk.no/english/category1045.html Norwegian Kennel Club Blog at DogWellNet: - under construction -
    • See a selection of Press articles related to IPFD's Harmonization of Genetic Testing HERE.
    • Our laboratory provides a complete testing service for veterinary surgeons to meet the diagnostic needs of your practice.     LABOKLIN is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.      
    • Royal Canin is a global leader in pet health nutrition. In an industry that continues to adapt to popular trends in cat and dog food, our mission will remain the same; to constantly bring, through Health Nutrition and shared knowledge, the most precise nutritional solution for cats' and dogs' health nutrition needs, by building on constantly deepened scientific knowledge and Royal Canin's roots in the feline and canine professional networks.
    • The SKK - Svenka Kennelklubben (Swedish Kennel Club, in English), is Sweden's largest organisation dedicated to dogs and dog owners. We represent the interests of our 300,000 members – first time dog owners, experienced breeders, hunters, dog lovers, puppy buyers, exhibitors, agility competitors and many more.   Website: http://www.skk.se/en/ Database: Avelsdata Follow this link for the SKK Blog at DogWellNet Follow this link for more information on the Swedish Kennel Club including our organizational structure, code of ethics, and more.
    • The Veterinary Genetics Laboratory (VGL) at the University of California, Davis provides dog DNA testing services, including forensic genetic analyses, to a world-wide clientele. Validation and standardization of genetic tests across laboratories are areas in which the VGL has been engaged in for many years, primarily via workshops supported by the International Society for Animal Genetics.     The VGL is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.      
    • The Canadian Kennel Club (CKC) is the primary registry body for purebred dogs in Canada and currently recognizes 175 breeds. As a non-profit organization, the CKC is dedicated to encouraging, guiding, and advancing the interests of purebred dogs and their responsible owners and breeders in Canada and promoting the knowledge and understanding of the benefits which dogs can bring to Canadian society.  
    • Reception within the Dog Community   Extensive Outreach: IPFD and DogWellNet.com are being received enthusiastically by the dog community (see examples of media coverage in our IPFD News section), and we are frequently used as a resource and our CEO and other IPFD contributors are approached by partner organizations for veterinary meetings, educational events for breeders and judges, and government and regulatory groups to share international perspectives on tough issues. Recent examples include: Outreach Seminar on Healthy Breeding - 42nd World Small Animal Veterinary Association Congress and 23rd FECAVA Eurocongress  
    • The Genomia laboratory is a private accredited genetic laboratory in Pilsen, Czech Republic. Genomia is engaged in genetic testing of humans, animals and pathogens. In humans, we are testing relationships between relatives – paternity and genealogy. For animals, we offer more than 150 tests for hereditary diseases, sex determination, parenthood determination and tests for coat appearance and colour. Genomia offers services to customers all over the world. Genomia cooperates with breeders from more than 38 countries on four continents.     Genomia is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.        
    • The Dog Breeding Reform Group (DBRG) is an organisation dedicated to improving the health and welfare of dogs through responsible breeding. It was founded in 2013 and became a Charitable Trust in 2015. Members of the DBRG include veterinary specialists, dog welfare and law experts, breeders and dog owners.
    • The Kennel Club is the largest organization in the UK devoted to dog health, welfare and training. Its objective is to ensure that dogs live healthy, happy lives with responsible owners.   Website: http://www.thekennelclub.org.uk  
    • IPFD is truly a "people driven" service organization. We allocate the bulk of our financial resources to maintain a small but dedicated team of consultants to manage our modest resources and facilitate the activities of our stakeholders, with the aim of achieving our collective goals.   Your generous donation to support IPFD and its programs helps ensure our long-term sustainability and supports ongoing efforts to create an enduring global collaboration that enhances the health, well-being, and welfare of all dogs worldwide.             By supporting the Harmonization of Genetic Testing for Dogs initiative you can help us impro
    • IPFD has endorsed the Global Pet Obesity Initiative Position Statement, joining 24 International Veterinary Professional Organizations, including the American Veterinary Medical Association Board of Directors, British Small Animal Veterinary Association, Canadian Veterinary Medical Association, World Small Animal Veterinary Association, and others.
    • CAG GmbH makes it easy to secure the genetic health of your four-legged friends. We provide the tools you need: a comprehensive offering of genetic tests, quick turn-around in the in-house accredited laboratory, and personal counseling to help you understand what the results really mean for you and your animal. With state-of-the-art technology, a robust R&D program, and dedicated specialists in animal genetics, CAG works with you to ensure the health and happiness of your best friend.     CAG GmbH is a proud sponsor of IPFD's Harmonization of Genetic Testing for Dogs Initiative.          
    • "ASHGI is dedicated to the increase and diffusion of knowledge of genetics in the Australian Shepherd, and the inherited diseases from which it sometimes suffers. We envision serving all Aussies, no matter what their purpose, the goals of their owners, or where they live. ASHGI will work both independently and in cooperation with researchers, breed clubs, canine health organizations and foundations that provide grant funds for canine genetics research."  
  • Pedigreed Breeds

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