Reminder: Login to access new features and members-only content!

Register to be a member of our community. Its easy!

Register a new account

Already a member?

Log In here!


Did you find our content interesting or helpful? Help support the IPFD enhance health, well-being and welfare for dogs everywhere.

Jump to content
International Partnership for Dogs - Enhancing Dog Health, Well-Being, and Welfare - Join Us
Search In
  • More options...
Find results that contain...
Find results in...

Population / Breed Level Approach - Approaches to combating inherited disease

    Identifying workable strategies that can be utilized by breeders and breed clubs to address inherited disorders present in breeding populations of purebred dogs is critical to reducing frequency of genetic diseases which directly impact the length and quality of dog's lives.


    1. ARTICLE: The challenges of pedigree dog health: approaches to combating inherited disease



    AUTHORS: Lindsay L Farrell*, Jeffrey J Schoenebeck, Pamela Wiener, Dylan N Clements and Kim M Summers


    excerpt... Lay summary



    "Humans and dogs have co-existed for thousands of years. Increasingly, over the last few centuries, many pedigree breeds have been generated based on selection for particular physical and/or behavioral characteristics, which have been fixed and maintained by inbreeding within closed familial lines.



    The development of such pedigree dog breeds can be both a blessing and a curse: desirable features are rigidly retained, but sometimes, undesirable disease-causing genes can be inadvertently fixed within the breed.



    Such diseases can reveal themselves only when two copies of the faulty version of the gene are inherited (recessive). Furthermore, if a Champion Sire is carrying such a disease gene, it can quickly spread across the whole breed. Similarly, if a breed is expanded from a small number of founder dogs, and one or more of these carry disease genes, again the disease frequency is likely to increase in the growing population. Sadly, some extreme forms of breed characteristics with a genetic basis can also contribute to issues of health and welfare.



    This review discusses, in an objective and dispassionate way, the background behind inherited genetic diseases in pedigree dogs and how breeding strategies and genetic testing can be helpful in combating and reducing disease frequency, whilst also maintaining genetic diversity within each breed. The strengths and weaknesses of such approaches are also discussed."





    Article source: Canine Genetics and Epidemiology 2015, 2:3 doi:10.1186/s40575-015-0014-9

  Report Entry

User Feedback

Recommended Comments

There are no comments to display.

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.

Add a comment...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

  • Create New...

Important Information

By using this site, you agree to our Terms of Use.