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Dermoid Sinus
Breed: Bedlington Terrier
General
Disease Name
Dermoid Sinus
OMIA
272
Gene Name
FGF3
Gene Name 2
sFGF4, FGF19, FGF3, ORAOV1
Mutation
large duplication
Test Type
Genetic Disease/Disorder
Details
The dominant inheritance of the "ridge" of hair typical of the Rhodesian Ridgeback breed means that dogs with either a single or double copy of the genes will appear the same, with the ridge of hair. However, those dogs homozygous (2 copies) of the gene are at a increased likelyhood to also develop a dermoid sinus. Age of onset is from birth. Symptoms can vary depending on the dermoid sinus location, and if it develops infection. Problems can include: discharge, infection, abscess, neurological problems.
Details 2
The dominant inheritance of the "ridge" of hair typical of the Rhodesian Ridgeback breed means that dogs with either a single or double copy of the genes will appear the same, with the ridge of hair. However, those dogs homozygous (2 copies) of the gene are at a increased likelyhood to also develop a dermoid sinus. Age of onset is from birth. Symptoms can vary depending on the dermoid sinus location, and if it develops infection. Problems can include: discharge, infection, abscess, neurological problems.
Published
Salmon Hillbertz, N.H., Isaksson, M., Karlsson, E.K., Hellmén, E., Pielberg, G.R., Savolainen, P., Wade, C.M., von Euler, H., Gustafson, U., Hedhammar, A., Nilsson, M., Lindblad-Toh, K., Andersson, L., Andersson, G. : Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs. Nat Genet 39:1318-20, 2007. Pubmed reference: 17906623. DOI: 10.1038/ng.2007.4.
Published 2
Karlsson, E.K., Baranowska, I., Wade, C.M., Salmon Hillbertz, N.H., Zody, M.C., Anderson, N., Biagi, T.M., Patterson, N., Pielberg, G.R., Kulbokas, E.J., Comstock, K.E., Keller, E.T., Mesirov, J.P., von Euler, H., Kämpe, O., Hedhammar, A., Lander, E.S., Andersson, G., Andersson, L., Lindblad-Toh, K. : Efficient mapping of mendelian traits in dogs through genome-wide association. Nat Genet 39:1321-8, 2007. Pubmed reference: 17906626. DOI: 10.1038/ng.2007.10.
Published 3
Waldo, J.T., Diaz, K.S. : Development and validation of a diagnostic test for Ridge allele copy number in Rhodesian Ridgeback dogs. Canine Genet Epidemiol 2:2, 2015. Pubmed reference: 26401330. DOI: 10.1186/s40575-015-0013-x.
Body/System/Process
Coat Colour/Pattern/Type
OMIA Url
Inheritance
AD
Breed Specific Info
Researched Breeds
Rhodesian Ridgeback
