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IPFD Harmonization of Genetic Testing for Dogs: Initiative Description


     

    IPFD is overseeing a multi-stakeholder, collaborative effort to create an open access, sustainable online resource that will:

    • Catalog information provided voluntarily from commercial test providers (CTPs) for genetic testing (GT) in dogs.  
    • Describe expertise, quality assurance, activities and resources; host expert panel reviews of genetic tests;
    • Coordinate a program for standardized proficiency testing and potentially peer review and audit;
    • Collate/assemble existing and new resources for genetic counselling and education; and provide the foundation for further developments.
       

    Our Steering Committee includes: Brenda Bonnett, CEO, IPFD; Aimee Llewellyn-Zaidi, Harmonization Project Director, IPFD; Diane Brown, AKC Canine Health Foundation; Matthew Breen, North Carolina State University; Cathryn Mellersh, Animal Health Trust; Sofia Malm, Swedish Kennel Club; Wim van Haeringen, VHL Genetics, Netherlands; Sue Pearce-Kelling, Optigen; and Eddie Dzuik; Orthopedic Foundation for Animals (OFA).  IPFD, our Partners and other stakeholders in this initiative recognize the input and work of many other experts and organizations in addressing the use of DNA tests in dogs.  The Harmonization initiative is working to further engage numerous experts to participate in panels to develop the resource, provide evaluation of tests and work to advance genetic counseling.

     

    IPFD is actively engaging Leadership Sponsors to help develop a prototype to be presented at the 3rd International Dog Health Workshop.   During the breakout session for this Theme we will look for input on the prototype and further discussion on how to move forward on this international collaboration.

     

     

    Some of our key Partners and Leadership Sponsors (more coming soon):

    Read more about IPFD Partners and Sponsors

     

     

                 WSAVA logo.jpg   ipfdlogo100x100transpsmpawprint.png          ofalogo100x100transparent.png        akc chf.jpg        Agria 2.png      

    AHT.png        SENT_NCS.png       opt11_logo.gif           vhl logo.png        MARS veterinary TM 12-3-14-2.png

              Neogen logo.jpg       Orivet.png     Genoscoper-Laboratories_LOGO-Flat_A4_Bitmap_RGB_WhiteBackground-conv.png         PPG Div Of GVS Logo.jpeg       Embark_Logo_Vt_CMYK.jpg

                                    logo-cag.jpg        80 x 80 mm genomia.jpg          VGL_center.png            Animal genetics.jpg

     

    Other potential sponsors and collaborators are welcome to contact us to explore opportunities.

    Contact:    IPFD CEO Brenda.Bonnett@ipfdogs.com or Project Director  Aimee.Llewellyn-Zaidi@ipfdogs.com

     

     

    “Mars Veterinary and the Mars Veterinary logo are trademarks of Mars, Incorporated and its affiliates.  Used with permission.”

     

     

    Executive Summary

     

    • There is currently no accreditation or standardization for genetic (DNA) testing for companion animals, and formal, international regulation/ oversight is unlikely.
    • There are increasing numbers of Commercial Test Providers (CTPs) offering a myriad of tests with reports of irregular and even suspected fraudulent activities.
    • There is a dire need for a collaborative international effort in determining the overall quality of commercial entities undertaking genetic testing in dogs, and of the specific tests/products they are offering. This is needed to:
      • Support consumers and confidence in DNA testing.
      • Support breeding practices to limit inherited disease and promote healthy offspring.
      • Further the scientific understanding of inherited diseases.
      • Reduce redundant efforts worldwide.
    • The International Partnership for Dogs (IPFD) is an independent, non-profit, multi-stakeholder organization; their web platform is DogWellNet.com.  IPFD has existed since August 2014 and an ongoing priority has been to address challenges in genetic testing; to help disseminate information and evidence to support breeding decisions; all with the goal of enhancing the health and welfare of dogs. IPFD, through the continued financial and in-kind commitment of its Partners, has not only built the online infrastructure for the initiative described herein, but has also built the collaborative relationships, trust and interest of the many stakeholders who will help create and use this resource e.g., kennel clubs, breed clubs, veterinarians, scientists, genetic advisors, breeders, the pet industry, as well as Commercial Test Providers (CTPs).
    • It is proposed that the IPFD oversee the creation of an open access, sustainable online resource that will catalog information provided voluntarily from commercial test providers (CTPs) for genetic testing (GT) in dogs.  This online resource will  describe expertise, quality assurance, activities and resources; host expert panel reviews of genetic tests; coordinate a program for standardized proficiency testing and potentially peer review and audit; collate/assemble existing and new resources for genetic counselling and education; and provide the foundation for further developments. IPFD, our Partners and other stakeholders in this initiative recognize great work and resources currently available (e.g. WSAVA Inherited Disease Committee Database). We welcome collaboration with other organizations and groups that share the goal of improving the appropriate use of genetic testing for dogs.
    • In addition to the IPFD and its partner organizations (including numerous national kennel clubs), specific financial and in-kind support for this prototype initiative is being provided by Leadership Sponsors, such as the Orthopedic Foundation for Animals, USA; the AKC Canine Health Foundation; numerous CTPs, academic institutions and corporate collaborators.   
    • Funding is being solicited from various stakeholders, to provide a robust service at minimal investment per stakeholder. 
    • Discussions among experts from numerous stakeholders have occurred over the last few years (e.g. at two previous International Dog Health Workshops and Canine and Feline Genome meetings).  Parameters have been identified that are needed for this resource and are similar to those being used in a similar resource for human genetic testing (Eurogentest).  Therefore, it is possible to move ahead in a timely fashion.
       

    Deliverables 

    • A working prototype of the Harmonization of Genetic Testing for Dogs online resource will be available on DogWellNet.com before April 2017. This will include:
      • Actual data from leadership sponsor CTPs.
      • Platform created for:
        • Existing resources identified and assembled for easy access by consumers. 
        • Expert panels to provide assessment of individual tests, their validation and application.
    • A steering committee has been struck, further participants / committees are being added.
    • The prototype and first two-years of the project will be supported by the IPFD and other sponsors.  It is envisioned that the quality assessment database will be self-sustaining as CTPs pay a participation fee for ongoing presence in the database in the future.
       

    Timeline

     

     

    Contact:   IPFD CEO Brenda.Bonnett@ipfdogs.com

    or Project Director  Aimee.Llewellyn-Zaidi@ipfdogs.com

                         

     



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