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Canine Leukocyte Adhesion Deficiency (CLAD)

Breed: Irish red and white Setter

Generic Phene Data

Breeds

Relevance Rating: There is moderate evidence or research available for these breeds

General

Disease Name
Canine Leukocyte Adhesion Deficiency (CLAD)
Mutation
c.107G>C
Test Type
Genetic Disease/Disorder
Details
Canine Leukocyte Adhesion Deficiency (CLAD), this rare but devastating condition is an inherited fatal immunodeficiency disease.This disorder affects the white blood cells ability to fight infection and is caused by misshapen proteins being formed on the surface of white blood cells. These proteins usually help the white blood cells to stick to each other and other cells in order to initiate an immune response to fight infections. Affected puppies white blood cells will not be as sticky and will not be able to fight infections as effectively. Age of onset is from birth. CLAD is characterized by recurrent, severe bacterial infections; impaired pus formation; and delayed wound healing. Infected animals usually have severe pyrexia (fever), loss of appetite and weight loss; response to antibiotic therapy is usually poor. Pups that inherit two recessive genes for CLAD usually die early in life from multiple severe infections, even when treated with massive doses of antibiotics.
Details 2
Canine Leukocyte Adhesion Deficiency (CLAD), this rare but devastating condition is an inherited fatal immunodeficiency disease.This disorder affects the white blood cells ability to fight infection and is caused by misshapen proteins being formed on the surface of white blood cells. These proteins usually help the white blood cells to stick to each other and other cells in order to initiate an immune response to fight infections. Affected puppies white blood cells will not be as sticky and will not be able to fight infections as effectively. Age of onset is from birth. CLAD is characterized by recurrent, severe bacterial infections; impaired pus formation; and delayed wound healing. Infected animals usually have severe pyrexia (fever), recurrent infections, neonatal omphalophlebitis, anorexia, lameness, impaired wound healing, severe skin infections, gingivitis, salivation, thickened mandible, enlarged metaphyses of the distal radius, ulna, tibia, and fibula, lameness, enlarged lymph nodes, and low body weight. Response to antibiotic therapy is usually poor. Pups that inherit two recessive genes for CLAD usually die early in life from multiple severe infections, even when treated with massive doses of antibiotics.
Published
Kijas, J.M.H., Bauer, T.R., Gafvert, S., Marklund, S., Trowald-Wigh, G., Johannisson, A., Hedhammar, A., Binns, M., Juneja, R.K., Hickstein, D.D., Andersson, L.: A missense mutation in the beta-2 integrin gene (ITGB2) causes canine leukocyte adhesion deficiency Genomics 61:101-107, 1999. Pubmed reference: 10512685. DOI: 10.1006/geno.1999.5948.

Breed Specific Data

Agrotis S.r.l.

GTP Name
Agrotis S.r.l.
Gene Name
ITGB2
Mutation
c.107G>C

Animal Health Trust (UK)

GTP Name
Animal Health Trust (UK)
GTP Disease Name
Leukocyte adhesion deficiency, type I
GTP Disease Synonym
Canine Leukocyte Adhesion Deficiency Type I, CLAD, FLAD, Feline Leukocyte Adhesion Deficiency
Gene Name
ITGB2
Mutation
c.107G>C
Nature of test
mutation test
GTP- or Breed-Specific Publications
Kijas, J.M.H., Bauer, T.R., Gafvert, S., Marklund, S., Trowald-Wigh, G., Johannisson, A., Hedhammar, A., Binns, M., Juneja, R.K., Hickstein, D.D., Andersson, L.: A missense mutation in the beta-2 inte
Application in the Breed
Carriers may be bred to normal animals (N/clad x N/N) . Offspring should be tested before breeding. No breeding two carriers (N/clad x N/clad) nor of affected animals (clad/clad). Pups exhibit recurrent infections, slow wound healing , low body weight, lack of appetite, lameness, enlarged longbone growth plates, and fever. Death around 6 months of age.
Inheritance
AR
FCI Number
330
GTP Breed
Irish red and white Setter

Anicom

GTP
GTP Name
Anicom
GTP Disease Name
Leukocyte adhesion deficiency, type I
Gene Name
ITGB2
Mutation
c.107G>C

BioBank AS

GTP Name
BioBank AS
Gene Name
ITGB2
Mutation
c.107G>C

CAG GmbH Center for Animal Genetics

GTP Name
Center for Animal Genetics
GTP Disease Name
Leukocyte adhesion deficiency, type I
GTP Disease Synonym
Canine Leukocyte Adhesion Deficiency Type I, CLAD, FLAD, Feline Leukocyte Adhesion Deficiency
Gene Name
ITGB2
Mutation
c.107G>C
Nature of test
mutation test
GTP- or Breed-Specific Publications
Kijas, J.M.H., Bauer, T.R., Gafvert, S., Marklund, S., Trowald-Wigh, G., Johannisson, A., Hedhammar, A., Binns, M., Juneja, R.K., Hickstein, D.D., Andersson, L.: A missense mutation in the beta-2 inte
Application in the Breed
Carriers may be bred to normal animals (N/clad x N/N) . Offspring should be tested before breeding. No breeding two carriers (N/clad x N/clad) nor of affected animals (clad/clad). Pups exhibit recurrent infections, slow wound healing , low body weight, lack of appetite, lameness, enlarged longbone growth plates, and fever. Death around 6 months of age.
Inheritance
AR
FCI Number
330
GTP Breed
Irish red and white Setter

Certagen GmbH

GTP Name
Certagen GmbH
Gene Name
ITGB2
Mutation
c.107G>C

CMSCH

GTP
GTP Name
CMSCH
Gene Name
ITGB2
Mutation
c.107G>C

DNA My Dog

GTP Name
DNA My Dog
GTP Disease Name
Leukocyte adhesion deficiency, type I
GTP Disease Synonym
Canine Leukocyte Adhesion Deficiency Type I, CLAD, FLAD, Feline Leukocyte Adhesion Deficiency
Gene Name
ITGB2
Mutation
c.107G>C
Nature of test
mutation test
GTP- or Breed-Specific Publications
Kijas, J.M.H., Bauer, T.R., Gafvert, S., Marklund, S., Trowald-Wigh, G., Johannisson, A., Hedhammar, A., Binns, M., Juneja, R.K., Hickstein, D.D., Andersson, L.: A missense mutation in the beta-2 inte
Application in the Breed
Carriers may be bred to normal animals (N/clad x N/N) . Offspring should be tested before breeding. No breeding two carriers (N/clad x N/clad) nor of affected animals (clad/clad). Pups exhibit recurrent infections, slow wound healing , low body weight, lack of appetite, lameness, enlarged longbone growth plates, and fever. Death around 6 months of age.
Inheritance
AR
This test is outsourced to:
Orivet
FCI Number
330
GTP Breed
Irish red and white Setter

Embark

GTP
GTP Name
Embark
GTP Disease Name
Leukocyte adhesion deficiency, type I
GTP Disease Synonym
Canine Leukocyte Adhesion Deficiency Type I, CLAD, FLAD, Feline Leukocyte Adhesion Deficiency
Gene Name
ITGB2
Mutation
c.107G>C
Nature of test
mutation test
GTP- or Breed-Specific Publications
Kijas, J.M.H., Bauer, T.R., Gafvert, S., Marklund, S., Trowald-Wigh, G., Johannisson, A., Hedhammar, A., Binns, M., Juneja, R.K., Hickstein, D.D., Andersson, L.: A missense mutation in the beta-2 inte
Application in the Breed
Carriers may be bred to normal animals (N/clad x N/N) . Offspring should be tested before breeding. No breeding two carriers (N/clad x N/clad) nor of affected animals (clad/clad). Pups exhibit recurrent infections, slow wound healing , low body weight, lack of appetite, lameness, enlarged longbone growth plates, and fever. Death around 6 months of age.
Inheritance
AR
FCI Number
330
GTP Breed
Irish red and white Setter

Genomia s.r.o

GTP Name
Genomia s.r.o
GTP Disease Name
Leukocyte adhesion deficiency, type I
Gene Name
ITGB2
Mutation
c.107G>C
Nature of test
mutation test
FCI Number
330
GTP Breed
Irish red and white Setter

INNO

GTP
GTP Name
INNO
Gene Name
ITGB2
Mutation
c.107G>C

Laboratorios Labocor S.L.

GTP Name
Laboratorios Labocor S.L.
Gene Name
ITGB2
Mutation
c.107G>C

Laboklin Gmbh & Co. KG

GTP Name
Laboklin Gmbh & Co. KG
GTP Disease Name
Leukocyte adhesion deficiency, type I
GTP Disease Synonym
Canine Leukocyte Adhesion Deficiency Type I, CLAD, FLAD, Feline Leukocyte Adhesion Deficiency
Gene Name
ITGB2
Mutation
c.107G>C
Nature of test
mutation test
GTP- or Breed-Specific Publications
Kijas, J.M.H., Bauer, T.R., Gafvert, S., Marklund, S., Trowald-Wigh, G., Johannisson, A., Hedhammar, A., Binns, M., Juneja, R.K., Hickstein, D.D., Andersson, L.: A missense mutation in the beta-2 inte
Application in the Breed
Carriers may be bred to normal animals (N/clad x N/N) . Offspring should be tested before breeding. No breeding two carriers (N/clad x N/clad) nor of affected animals (clad/clad). Pups exhibit recurrent infections, slow wound healing , low body weight, lack of appetite, lameness, enlarged longbone growth plates, and fever. Death around 6 months of age.
Inheritance
AR
FCI Number
330
GTP Breed
Irish red and white Setter

Orivet Genetic Pet Care

GTP Name
Orivet Genetic Pet Care
GTP Disease Name
Leukocyte adhesion deficiency, type I
GTP Disease Synonym
Canine Leukocyte Adhesion Deficiency Type I, CLAD, FLAD, Feline Leukocyte Adhesion Deficiency
Gene Name
ITGB2
Mutation
c.107G>C
Nature of test
mutation test
GTP- or Breed-Specific Publications
Kijas, J.M.H., Bauer, T.R., Gafvert, S., Marklund, S., Trowald-Wigh, G., Johannisson, A., Hedhammar, A., Binns, M., Juneja, R.K., Hickstein, D.D., Andersson, L.: A missense mutation in the beta-2 inte
Application in the Breed
Carriers may be bred to normal animals (N/clad x N/N) . Offspring should be tested before breeding. No breeding two carriers (N/clad x N/clad) nor of affected animals (clad/clad). Pups exhibit recurrent infections, slow wound healing , low body weight, lack of appetite, lameness, enlarged longbone growth plates, and fever. Death around 6 months of age.
Inheritance
AR
FCI Number
330
GTP Breed
Irish red and white Setter

Paw Print Genetics

GTP Name
Paw Print Genetics
GTP Disease Name
Leukocyte Adhesion Deficiency, Type I
Gene Name
ITGB2
Mutation
c.107G>C
Nature of test
mutation test
FCI Number
330

PharmaDNA

GTP
GTP Name
PharmaDNA
Gene Name
ITGB2
Mutation
c.107G>C

Progènes-ADN

GTP Name
Progenes ADN
Gene Name
ITGB2
Mutation
c.107G>C

Veterinary Genetics Laboratory

GTP Name
Veterinary Genetics Laboratory
GTP Disease Name
Leukocyte Adhesion Deficiency, Type I
Gene Name
ITGB2
Mutation
c.107G>C
Nature of test
mutation test

VHL Genetics

GTP Name
VHL Genetics
Gene Name
ITGB2
Mutation
c.107G>C

Zoolyx

GTP
GTP Name
Zoolyx
Gene Name
ITGB2
Mutation
c.107G>C
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