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Narcolepsy

Breed: Labrador Retriever

Generic Phene Data

General

Disease Name
Narcolepsy
OMIA
703
Gene Name
HCRTR2
Mutation
c.1103+5G>A
Mutation 2
c.160G>A
Mutation 3
c.647-35ins226bp
OMIM
161400
Disease Code
NAR
Test Type
Genetic Disease/Disorder
Details
Narcolepsy causes extreme sleepiness in dogs. Signs include: dogs unable to maintain long stretches of wakefulness, falling asleep faster than normal dogs, buckling of hind legs and dropping neck (cataplexy) in response to positive stimui (such as treats). Age of onset from 4 weeks - 6 months. Narcolepsy is not considered progressive or life-threatening. However, attacks of cataplexy can be very distressing for owners.
Details 2
Narcolepsy causes extreme sleepiness in dogs. Signs include: dogs unable to maintain long stretches of wakefulness, falling asleep faster than normal dogs, buckling of hind legs and dropping neck (cataplexy) in response to positive stimui (such as treats). Age of onset from 4 weeks - 6 months. Narcolepsy is not considered progressive or life-threatening. However, attacks of cataplexy can be distressing for owners.
Patents/ Licences
US20050048538 A1
Published
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X.Y., Qiu, X.H., de, Jong, P.J., Nishino, S., Mignot, E. : The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene Cell 98:365-376, 1999. Pubmed reference: 10458611.
Published 2
Hungs, M., Fan, J., Lin, L., Lin, X.Y., Grigoriadis, D., Maki, R.A., Mignot, E. : Identification and functional analysis of mutations in the hypocretin (Orexin) genes of narcoleptic canines (vol 11, pg 531, 2001) Genome Research 11:919, 2001.
Published 3
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X.Y., Qiu, X.H., de, Jong, P.J., Nishino, S., Mignot, E. : The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene Cell 98:365-376, 1999. Pubmed reference: 10458611.
Body/System/Process
Neurologic
Inheritance
AR
Gene Name Text
hypocretin (orexin) receptor 2

Breed Specific Data

CAG GmbH Center for Animal Genetics

Link to GTP
OMIA
GTP Disease Name
Narcolepsy (Labrador Retriever Type)
Gene Name
HCRTR2
Mutation
c.1103+5G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X.Y., Qiu, X.H., de, Jong, P.J., Nishino, S., Mignot, E. : The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (o
Application in the Breed
Carriers may be bred to normal animals (N/nar x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/nar x N/nar) nor of affected animals (nar/nar). Sleepy during the day, drop suddenly from wakefulness into REM sleep, and can become cataleptic when startled
Inheritance
AR

Embark

Link to GTP
GTP
OMIA
GTP Disease Name
Narcolepsy (Labrador Retriever Type)
Gene Name
HCRTR2
Mutation
c.1103+5G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X.Y., Qiu, X.H., de, Jong, P.J., Nishino, S., Mignot, E. : The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (o
Application in the Breed
Carriers may be bred to normal animals (N/nar x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/nar x N/nar) nor of affected animals (nar/nar). Sleepy during the day, drop suddenly from wakefulness into REM sleep, and can become cataleptic when startled
Inheritance
AR

Genoscoper Laboratories Oy

Link to GTP
OMIA
GTP Disease Name
Narcolepsy (Labrador Retriever Type)
Gene Name
HCRTR2
Mutation
c.1103+5G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X.Y., Qiu, X.H., de, Jong, P.J., Nishino, S., Mignot, E. : The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (o
Application in the Breed
Carriers may be bred to normal animals (N/nar x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/nar x N/nar) nor of affected animals (nar/nar). Sleepy during the day, drop suddenly from wakefulness into REM sleep, and can become cataleptic when startled
Inheritance
AR

Laboklin Gmbh & Co. KG

Link to GTP
OMIA
GTP Disease Name
Narcolepsy (Labrador Retriever Type)
Gene Name
HCRTR2
Mutation
c.1103+5G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X.Y., Qiu, X.H., de, Jong, P.J., Nishino, S., Mignot, E. : The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (o
Application in the Breed
Carriers may be bred to normal animals (N/nar x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/nar x N/nar) nor of affected animals (nar/nar). Sleepy during the day, drop suddenly from wakefulness into REM sleep, and can become cataleptic when startled
Inheritance
AR

OptiGen

Link to GTP
GTP
OMIA
GTP Disease Name
Narcolepsy (Labrador Retriever Type)
Gene Name
HCRTR2
Mutation
c.1103+5G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X.Y., Qiu, X.H., de, Jong, P.J., Nishino, S., Mignot, E. : The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (o
Application in the Breed
Carriers may be bred to normal animals (N/nar x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/nar x N/nar) nor of affected animals (nar/nar). Sleepy during the day, drop suddenly from wakefulness into REM sleep, and can become cataleptic when startled
Inheritance
AR

VHL Genetics

Link to GTP
OMIA
GTP Disease Name
Narcolepsy (Labrador Retriever Type)
Gene Name
HCRTR2
Mutation
c.1103+5G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X.Y., Qiu, X.H., de, Jong, P.J., Nishino, S., Mignot, E. : The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (o
Application in the Breed
Carriers may be bred to normal animals (N/nar x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/nar x N/nar) nor of affected animals (nar/nar). Sleepy during the day, drop suddenly from wakefulness into REM sleep, and can become cataleptic when startled
Inheritance
AR

Wisdom Health (formerly Mars Veterinary)

Link to GTP
OMIA
GTP Disease Name
Narcolepsy (Labrador Retriever Type)
Gene Name
HCRTR2
Mutation
c.1103+5G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X.Y., Qiu, X.H., de, Jong, P.J., Nishino, S., Mignot, E. : The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (o
Application in the Breed
Carriers may be bred to normal animals (N/nar x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/nar x N/nar) nor of affected animals (nar/nar). Sleepy during the day, drop suddenly from wakefulness into REM sleep, and can become cataleptic when startled
Inheritance
AR

EVG Diagnostics

Link to GTP
OMIA
Gene Name
HCRTR2
Mutation
c.1103+5G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Cell, Vol. 98, 365?376, August 6, 1999

VetGen LLC

Link to GTP
OMIA
Gene Name
HCRTR2
Mutation
c.1103+5G>A

DNA My Dog

Link to GTP
OMIA
GTP Disease Name
Narcolepsy (Labrador Retriever Type)
Gene Name
HCRTR2
Mutation
c.160G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Hungs, M., Fan, J., Lin, L., Lin, X.Y., Grigoriadis, D., Maki, R.A., Mignot, E. : Identification and functional analysis of mutations in the hypocretin (Orexin) genes of narcoleptic canines (vol 11, p
Application in the Breed
Carriers may be bred to normal animals (N/nar x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/nar x N/nar) nor of affected animals (nar/nar). Sleepy during the day, drop suddenly from wakefulness into REM sleep, and can become cataleptic when startled
Inheritance
AR

Orivet Genetic Pet Care

Link to GTP
OMIA
GTP Disease Name
Narcolepsy (Labrador Retriever Type)
Gene Name
HCRTR2
Mutation
c.160G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Hungs, M., Fan, J., Lin, L., Lin, X.Y., Grigoriadis, D., Maki, R.A., Mignot, E. : Identification and functional analysis of mutations in the hypocretin (Orexin) genes of narcoleptic canines (vol 11, p
Application in the Breed
Carriers may be bred to normal animals (N/nar x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/nar x N/nar) nor of affected animals (nar/nar). Sleepy during the day, drop suddenly from wakefulness into REM sleep, and can become cataleptic when startled
Inheritance
AR

Paw Print Genetics

Link to GTP
OMIA
GTP Disease Name
Narcolepsy (Labrador Retriever Type)
Gene Name
HCRTR2
Mutation
Point Mutation
Nature of test
mutation test
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