Ectodermal Dysplasia XHED, XLED
Breed: Xoloitzcuintle/ Miniature
Generic Phene Data
Breeds
Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful for these breeds
General
Disease Name
Ectodermal Dysplasia XHED, XLED
Gene Name 2
EDA
Mutation
c.910-1G>A
Mutation 2
c.57_63dup7
Details
Ectodermal Dysplasia XHED, XLED causes dogs to have varying degrees of hairlessness. Most often, almost the entire body is affected. but some breeds also have tufts of hair on the limbs and head. Other effects (severity can vary signifigantly) can include abnormal teeth, missing teeth, long and/or brittle toenails. Age of onset is from birth, with any non-hair related effects becoming apparent with age. While considered a desirable trait for some breeds, breeders should be aware that neonatal deaths are more common in hairless pups than in their normal littermates. This risk increases when breeding two hairless dogs together - often resulting in smaller litter sizes.
Details 2
Ectodermal Dysplasia causes dogs to have varying degrees of hairlessness. Most often, almost the entire body is affected. but some breeds also have tufts of hair on the limbs and head. Other effects (severity can vary signifigantly) can include abnormal teeth, missing teeth, long and/or brittle toenails. Age of onset is from birth, with any non-hair related effects becoming apparent with age. While considered a desirable trait for some breeds, breeders should be aware that neonatal deaths are more common in hairless pups than in their normal littermates. This risk increases when breeding two hairless dogs together - often resulting in smaller litter sizes.
Published
Drögemüller, C., Karlsson, E.K., Hytönen, M.K., Perloski, M., Dolf, G., Sainio, K., Lohi, H., Lindblad-Toh, K., Leeb, T. : A mutation in hairless dogs implicates FOXI3 in ectodermal development. Science 321:1462, 2008. Pubmed reference: 18787161. DOI: 10.1126/science.1162525.
Breed Specific Data
BioBank AS
GTP
GTP Name
BioBank AS
Gene Name
FOXI3
Mutation
c.57_63dup7
Certagen GmbH
GTP
GTP Name
Certagen GmbH
Gene Name
FOXI3
Mutation
c.57_63dup7
CMSCH
GTP
GTP Name
CMSCH
Gene Name
FOXI3
Mutation
c.57_63dup7
INNO
GTP
GTP Name
INNO
Gene Name
FOXI3
Mutation
c.57_63dup7
Laboratorios Labocor S.L.
GTP Name
Laboratorios Labocor S.L.
Gene Name
FOXI3
Mutation
c.57_63dup7
Paw Print Genetics
GTP Name
Paw Print Genetics
GTP Disease Name
Hr Locus (FOXI3 Hairless Gene Test)
Gene Name
FOXI3
Mutation
c.57_63dup7
Nature of test
mutation test
FCI Number
234
PharmaDNA
GTP
GTP Name
PharmaDNA
Gene Name
FOXI3
Mutation
c.57_63dup7
Progènes-ADN
GTP
GTP Name
Progenes ADN
Gene Name
FOXI3
Mutation
c.57_63dup7
Zoolyx
GTP
GTP Name
Zoolyx
Gene Name
FOXI3
Mutation
c.57_63dup7
Agrotis S.r.l.
GTP
GTP Name
Agrotis S.r.l.
Gene Name
FOXI3
Mutation
c.57_63dup7
VHL Genetics
GTP
GTP Name
VHL Genetics
Gene Name
FOXI3
Mutation
c.57_63dup7