Reminder: Login to access new features and members-only content!

Register to be a member of our community. Its easy!

Register a new account

Already a member?

Log In here!

Donate

Did you find our content interesting or helpful? Help support the IPFD enhance health, well-being and welfare for dogs everywhere.

Jump to content
  •   Language
  • Sign Up

International Partnership for Dogs - Enhancing Dog Health, Well-Being, and Welfare - Join Us.

Persistent Mullerian Duct Syndrome

Breed: Miniature Schnauzer/ Black

Generic Phene Data

General

Disease Name
Persistent Mullerian Duct Syndrome
Mutation
c.238C>T
Test Type
Genetic Disease/Disorder
Details
Unilaterally or bilaterally cryptorchid, those with at least one descended testicle are fertile. Internally, female organs also exist in affected male dogs, including oviducts, uterus, and cervix.
Details 2
Homozygous affected males have normal male external genitalia, except that approximately 50% are unilaterally or bilaterally cryptorchid. PMDS males having at least one descended testicle can be fertile. Carrier males and carrier females are reproductively normal. PMDS dogs may present at any age as a dog with normal male external genitalia or a cryptorchid dog. If cryptorchid, they may present as an adult with signs of testicular tumor. As pyometra can be a sequelae, affected dogs may present with typical signs,such as polydipsia, polyuria and inappetance. (From OMIA)
Published
Wu, X., Wan, S., Pujar, S., Haskins, ME., Schlafer, DH., Lee, MM., Meyers-Wallen, VN. : A Single Base Pair Mutation Encoding a Premature Stop Codon in the MIS type II receptor is Responsible for Canine Persistent Mullerian Duct Syndrome. J Androl 30:46-56, 2009. , Pujar, S., Meyers-Wallen, VN. : A molecular diagnostic test for persistent Müllerian duct syndrome in miniature schnauzer dogs. Sex Dev 3:326-8, 2009. Pubmed reference: 20051676. DOI: 10.1159/000273264.

Breed Specific Data

Agrotis S.r.l.

GTP Name
Agrotis S.r.l.
Gene Name
AMHR2
Mutation
c.238C>T

BioBank AS

GTP Name
BioBank AS
Gene Name
AMHR2
Mutation
c.238C>T

CAG GmbH Center for Animal Genetics

GTP Name
Center for Animal Genetics
GTP Disease Name
Persistent Mullerian Duct Syndrome
Gene Name
AMHR2
Mutation
c.238C>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Wu, X., Wan, S., Pujar, S., Haskins, ME., Schlafer, DH., Lee, MM., Meyers-Wallen, VN. : A Single Base Pair Mutation Encoding a Premature Stop Codon in the MIS type II receptor is Responsible for Canin
Application in the Breed
Carriers may be bred to normal animals (N/pmds x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/pmds x N/pmds) nor of affected animals (pmds/pmds). Unilaterally or bilaterally cryptorchid, those with at least one descended testicle are fertile. Internally, female organs also exist in affected male dogs, including oviducts, uterus, and cervix.
Inheritance
AR
FCI Number
183
GTP Breed
Miniature Schnauzer/ Black

Certagen GmbH

GTP Name
Certagen GmbH
Gene Name
AMHR2
Mutation
c.238C>T

CMSCH

GTP
GTP Name
CMSCH
Gene Name
AMHR2
Mutation
c.238C>T

Genoscoper Laboratories Oy

GTP Name
Genoscoper Laboratories Oy
GTP Disease Name
Persistent Mullerian Duct Syndrome
Gene Name
AMHR2
Mutation
c.238C>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Wu, X., Wan, S., Pujar, S., Haskins, ME., Schlafer, DH., Lee, MM., Meyers-Wallen, VN. : A Single Base Pair Mutation Encoding a Premature Stop Codon in the MIS type II receptor is Responsible for Canin
Application in the Breed
Carriers may be bred to normal animals (N/pmds x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/pmds x N/pmds) nor of affected animals (pmds/pmds). Unilaterally or bilaterally cryptorchid, those with at least one descended testicle are fertile. Internally, female organs also exist in affected male dogs, including oviducts, uterus, and cervix.
Inheritance
AR
FCI Number
183
GTP Breed
Miniature Schnauzer/ Black

INNO

GTP
GTP Name
INNO
Gene Name
AMHR2
Mutation
c.238C>T

Laboratorios Labocor S.L.

GTP Name
Laboratorios Labocor S.L.
Gene Name
AMHR2
Mutation
c.238C>T

Paw Print Genetics

GTP Name
Paw Print Genetics
GTP Disease Name
Persistent Mullerian Duct Syndrome
Gene Name
AMHR2
Mutation
c.238C>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Wu, X., Wan, S., Pujar, S., Haskins, ME., Schlafer, DH., Lee, MM., Meyers-Wallen, VN. : A Single Base Pair Mutation Encoding a Premature Stop Codon in the MIS type II receptor is Responsible for Canin
Application in the Breed
Carriers may be bred to normal animals (N/pmds x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/pmds x N/pmds) nor of affected animals (pmds/pmds). Unilaterally or bilaterally cryptorchid, those with at least one descended testicle are fertile. Internally, female organs also exist in affected male dogs, including oviducts, uterus, and cervix.
Inheritance
AR
FCI Number
183
GTP Breed
Miniature Schnauzer/ Black

PharmaDNA

GTP
GTP Name
PharmaDNA
Gene Name
AMHR2
Mutation
c.238C>T

Progènes-ADN

GTP Name
Progenes ADN
Gene Name
AMHR2
Mutation
c.238C>T

University of Minnesota Canine Genetics Lab

GTP Name
University of Minnesota Canine Genetics Lab
Gene Name
AMHR2/MISRII
Mutation
c.238C>T
FCI Number
183

VHL Genetics

GTP Name
VHL Genetics
Gene Name
AMHR2
Mutation
c.238C>T

Wisdom Health (formerly Mars Veterinary)

GTP Name
Wisdom Health (formerly Mars Veterinary)
GTP Disease Name
Persistent Mullerian Duct Syndrome
Gene Name
AMHR2
Mutation
c.238C>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Wu, X., Wan, S., Pujar, S., Haskins, ME., Schlafer, DH., Lee, MM., Meyers-Wallen, VN. : A Single Base Pair Mutation Encoding a Premature Stop Codon in the MIS type II receptor is Responsible for Canin
Application in the Breed
Carriers may be bred to normal animals (N/pmds x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/pmds x N/pmds) nor of affected animals (pmds/pmds). Unilaterally or bilaterally cryptorchid, those with at least one descended testicle are fertile. Internally, female organs also exist in affected male dogs, including oviducts, uterus, and cervix.
Inheritance
AR
FCI Number
183
GTP Breed
Miniature Schnauzer/ Black

Zoolyx

GTP
GTP Name
Zoolyx
Gene Name
AMHR2
Mutation
c.238C>T
×
×
  • Create New...

Important Information

By using this site, you agree to our Terms of Use.