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Prekallikrein Deficiency

Breed: Bichon frisé

Breeds

Relevance Rating: Unknown, not evaluated or no evidence for test in this breed

General

Disease Name
Prekallikrein Deficiency
Mutation
c.988T>A
Test Type
Genetic Disease/Disorder
Details
Prekallikrein deficiency is a rare inherited blood disorder affecting dogs that increases the time for blood to clot. Does not nessesarily impact lifespan.
Details 2
Prekallikrein (PK) deficiency is an uncommon disorder in dogs... we describe a case of a dog that was referred for neurological defects and had a prolonged activated partial thromboplastin time (aPTT) and normal prothrombin time (PT) with no hemostatic defects. By using human PK-deficient plasma, the dog was diagnosed to have PK deficiency. (From Okawa et al, 2011)
Published
Okawa, T., Yanase, T., Shimokawa Miyama, T., Hiraoka, H., Baba, K., Tani, K., Okuda, M., Mizuno, T. : Prekallikrein deficiency in a dog. J Vet Med Sci 73:107-11, 2011. Pubmed reference: 20736516.
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