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Von Willebrand Disease I

Breed: Collies

Generic Phene Data

Breeds

General

Disease Name
Von Willebrand Disease I
OMIA
1057
Gene Name
VWF
Mutation
c.7142C>T
Mutation 2
c.7437G>A
OMIM
193400
Disease Code
VWF1
Test Type
Genetic Disease/Disorder
Details
Von Willebrand?s disease (vWD) is a blood disease caused by a deficiency of von Willebrand Factor (vWF), an adhesive glycoprotein in the blood required for normal blood clotting. A lack of vWF impairs platelet stickiness and clumping. Symptoms can include: spontaneous hemorrhage from mucosal surfaces, nosebleeds, blood in the faeces, bloody urine, bleeding gums, excessive vaginal bleeding, bruising, prolonged bleeding after surgery or trauma, blood loss anemia. The inheritance of the severe forms (Types II and III) is autosomal recessive. The milder form (Type I) may be autosomal recessive or incompletely dominant. This is the most common hereditary blood clotting disorder in dogs.
Details 2
Von Willebrand?s disease (vWD) is a blood disease caused by a deficiency of von Willebrand Factor (vWF), an adhesive glycoprotein in the blood required for normal blood clotting. A lack of vWF impairs platelet stickiness and clumping. Symptoms can include: spontaneous hemorrhage from mucosal surfaces, nosebleeds, blood in the faeces, bloody urine, bleeding gums, excessive vaginal bleeding, bruising, prolonged bleeding after surgery or trauma, blood loss anemia. The inheritance of the severe forms (Types II and III) is autosomal recessive. The milder form (Type I) may be autosomal recessive or incompletely dominant. This is the most common hereditary blood clotting disorder in dogs.
Published
Brewer, G.J., Venta, P.J., Schall, W., Yuzbasiyan-Gurkan, V., Li, J. : DNA tests for von Willebrand?s disease in Dobermans, Scotties, Shelties and Manchester terriers. Canine Practice 23:45, 1998.
Published 2
Nichols, T.C., Hough, C., Agerso¸, H., Ezban, M., Lillicrap, D. : Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies. J Thromb Haemost 14:894-905, 2016. Pubmed reference: 26924758. DOI: 10.1111/jth.13301.
Body/System/Process
Blood
Inheritance
AR
Gene Name Text
von Willebrand factor

Breed Specific Data

DNA My Dog

Link to GTP
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7437G>A
Nature of test
mutation test

Orivet Genetic Pet Care

Link to GTP
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7437G>A
Nature of test
mutation test

GenSol Diagnostics

Link to GTP
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7437G>A

GenSol Diagnostics

Link to GTP
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7437G>A

Anicom

Link to GTP
GTP
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7437G>A
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