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Generic Phene Data
Breeds
Relevance Rating: There is strong evidence or research available for these breeds
Relevance Rating: There is moderate evidence or research available for these breeds
Relevance Rating: There is some evidence or research available in this breed
Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful in this breed
General
Disease Name
Hyperuricosuria and Hyperuricemia (HUU)
Mutation
c.616G>T
Mutation 2
c.G563T
Test Type
Genetic Disease/Disorder
Details
Hyperuricosuria (HUU) describes elevated levels of uric acid in the urine causing the formation of calculi (stones) in the urinary tract. These stones form in the bladders or sometimes kidneys, requiring surgical removal, and can be difficult to treat. HUU can occur in any breed but is most commonly associated with the Dalmatian, as Dalmatians are homozygous for HUU (HU/HU). Outcrossing programs have introduced ?low uric acid? dogs, derived from Dalmatian x Pointer backcrosses, into the purebred gene pool, providing a means for breeders to reduce incidence of the disease and maintain the breed characteristics. This mutation is not the sole cause of urate bladder stones in dogs, so may not account for other causes of stones, such as liver disease and diet.
Details 2
Hyperuricosuria (HUU) describes elevated levels of uric acid in the urine, resulting in urolithiasis, the formation of calculi (stones) in the urinary tract. These stones form in their bladders or sometimes kidneys, requiring surgical removal. These stones can be difficult to treat. HUU can occur in any breed but is most commonly associated with the Dalmatian, as Dalmatians are homozygous for HUU (HU/HU). Outcrossing programs have introduced ?low uric acid? dogs, derived from Dalmatian x Pointer backcrosses, into the purebred gene pool, providing a means for breeders to reduce incidence of the disease and maintain the breed characteristics. This mutation is not the sole cause of urate bladder stones in dogs, so may not account for other causes of stones, such as liver disease and diet.
Published
Bannasch, D., Safra, N., Young, A., Karmi, N., Schaible, RS., Ling, GV. : Mutations in the SLC2A9 gene cause hyperuricosuria and hyperuricemia in the dog. PLoS Genet 4:e1000246, 2008. Pubmed reference: 18989453. DOI: 10.1371/journal.pgen.1000246.
Breed Specific Data
Agrotis S.r.l.
GTP
GTP Name
Agrotis S.r.l.
Gene Name
SLC2A9
Mutation
c.616G>T
Anicom
GTP
GTP Name
Anicom
GTP Disease Name
urolithiasis, urate stones, uric acid secretion, hyperuricemia
Gene Name
SLC2A9
Mutation
c.616G>T
BioBank AS
GTP
GTP Name
BioBank AS
Gene Name
SLC2A9
Mutation
c.616G>T
Certagen GmbH
GTP
GTP Name
Certagen GmbH
Gene Name
SLC2A9
Mutation
c.616G>T
CMSCH
GTP
GTP Name
CMSCH
Gene Name
SLC2A9
Mutation
c.616G>T
INNO
GTP
GTP Name
INNO
Gene Name
SLC2A9
Mutation
c.616G>T
Laboratorios Labocor S.L.
GTP Name
Laboratorios Labocor S.L.
Gene Name
SLC2A9
Mutation
c.616G>T
Paw Print Genetics
GTP Name
Paw Print Genetics
GTP Disease Name
urolithiasis, urate stones, uric acid secretion, hyperuricemia
Gene Name
SLC2A9
Mutation
c.616G>T
Nature of test
mutation test
FCI Number
166
PharmaDNA
GTP
GTP Name
PharmaDNA
Gene Name
SLC2A9
Mutation
c.616G>T
Progènes-ADN
GTP
GTP Name
Progenes ADN
Gene Name
SLC2A9
Mutation
c.616G>T
VetGen LLC
GTP
GTP Name
VetGen LLC
Gene Name
SLC2A9
Mutation
c.616G>T
VHL Genetics
GTP
GTP Name
VHL Genetics
Gene Name
SLC2A9
Mutation
c.616G>T
Zoolyx
GTP
GTP Name
Zoolyx
Gene Name
SLC2A9
Mutation
c.616G>T
