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Von Willebrand Disease I

Breed: Dobermann

Generic Phene Data

Breeds
Relevance Rating: All current available evidence has been reviewed, but relevancy is inconclusive, AND/OR the clinical form of this disease has never been seen for these breeds

General

Disease Name
Von Willebrand Disease I
Mutation
c.7142C>T
Mutation 2
c.7437G>A
Test Type
Genetic Disease/Disorder
Details
Von Willebrand?s disease (vWD) is a blood disease caused by a deficiency of von Willebrand Factor (vWF), an adhesive glycoprotein in the blood required for normal blood clotting. A lack of vWF impairs platelet stickiness and clumping. Symptoms can include: spontaneous hemorrhage from mucosal surfaces, nosebleeds, blood in the faeces, bloody urine, bleeding gums, excessive vaginal bleeding, bruising, prolonged bleeding after surgery or trauma, blood loss anemia. The inheritance of the severe forms (Types II and III) is autosomal recessive. The milder form (Type I) may be autosomal recessive or incompletely dominant. This is the most common hereditary blood clotting disorder in dogs.
Details 2
Von Willebrand?s disease (vWD) is a blood disease caused by a deficiency of von Willebrand Factor (vWF), an adhesive glycoprotein in the blood required for normal blood clotting. A lack of vWF impairs platelet stickiness and clumping. Symptoms can include: spontaneous hemorrhage from mucosal surfaces, nosebleeds, blood in the faeces, bloody urine, bleeding gums, excessive vaginal bleeding, bruising, prolonged bleeding after surgery or trauma, blood loss anemia. The inheritance of the severe forms (Types II and III) is autosomal recessive. The milder form (Type I) may be autosomal recessive or incompletely dominant. This is the most common hereditary blood clotting disorder in dogs.
Published
Brewer, G.J., Venta, P.J., Schall, W., Yuzbasiyan-Gurkan, V., Li, J. : DNA tests for von Willebrand?s disease in Dobermans, Scotties, Shelties and Manchester terriers. Canine Practice 23:45, 1998.

Breed Specific Info

Researched Breeds
Doberman Pincher

Breed Specific Data

Agrotis S.r.l.

GTP Name
Agrotis S.r.l.
Breed
Gene Name
VWF
Mutation
c.7437G>A; c.7142C>T

Anicom

GTP
GTP Name
Anicom
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7142C>T

Antagene

GTP
GTP Name
Antagene
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7142C>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Nichols, T.C., Hough, C., Agers??, H., Ezban, M., Lillicrap, D. : Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies.
Inheritance
AR
FCI Number
143
GTP Breed
Doberman Pinscher

BioBank AS

GTP Name
BioBank AS
Breed
Gene Name
VWF
Mutation
c.7437G>A; c.7142C>T

CAG GmbH Center for Animal Genetics

GTP Name
Center for Animal Genetics
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7437G>A
Nature of test
mutation test
FCI Number
143
GTP Breed
Doberman Pinscher

Certagen GmbH

GTP Name
Certagen GmbH
Breed
Gene Name
VWF
Mutation
c.7437G>A; c.7142C>T

CMSCH

GTP
GTP Name
CMSCH
Breed
Gene Name
VWF
Mutation
c.7437G>A; c.7142C>T

DNA My Dog

GTP Name
DNA My Dog
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7142C>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Nichols, T.C., Hough, C., Agers??, H., Ezban, M., Lillicrap, D. : Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies.
Inheritance
AR
This test is outsourced to:
Orivet
FCI Number
143
GTP Breed
Dobermann

Embark

GTP
GTP Name
Embark
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7142C>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Nichols, T.C., Hough, C., Agers??, H., Ezban, M., Lillicrap, D. : Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies.
Inheritance
AR
FCI Number
143
GTP Breed
Dobermann

EVG Diagnostics

GTP Name
EVG Molecular Diagnostics
Breed
Gene Name
VWF
Mutation
c.7437G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Am J Vet Res. 2001 Mar;62(3):364-9.

Genomia s.r.o

GTP Name
Genomia s.r.o
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7437G>A
Nature of test
mutation test
FCI Number
143
GTP Breed
Dobermann

Genoscoper Laboratories Oy

GTP Name
Genoscoper Laboratories Oy
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7142C>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Nichols, T.C., Hough, C., Agers??, H., Ezban, M., Lillicrap, D. : Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies.
Inheritance
AR
FCI Number
143
GTP Breed
Dobermann

GenSol Diagnostics

GTP Name
GenSol Diagnostics
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7437G>A

INNO

GTP
GTP Name
INNO
Breed
Gene Name
VWF
Mutation
c.7437G>A; c.7142C>T

Laboratorios Labocor S.L.

GTP Name
Laboratorios Labocor S.L.
Breed
Gene Name
VWF
Mutation
c.7437G>A; c.7142C>T

Laboklin Gmbh & Co. KG

GTP Name
Laboklin Gmbh & Co. KG
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7437G>A; c.7142C>T
Nature of test
mutation test
FCI Number
143
GTP Breed
Dobermann

Orivet Genetic Pet Care

GTP Name
Orivet Genetic Pet Care
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7142C>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Nichols, T.C., Hough, C., Agers??, H., Ezban, M., Lillicrap, D. : Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies.
Inheritance
AR
FCI Number
143
GTP Breed
Dobermann

Paw Print Genetics

GTP Name
Paw Print Genetics
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
Point Mutation
Nature of test
mutation test
FCI Number
143

PharmaDNA

GTP
GTP Name
PharmaDNA
Breed
Gene Name
VWF
Mutation
c.7437G>A; c.7142C>T

Independent Veterinary Laboratory POISK

GTP Name
Independent Veterinary Laboratory POISK
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7437G>A

Progènes-ADN

GTP Name
Progenes ADN
Breed
Gene Name
VWF
Mutation
c.7437G>A; c.7142C>T

Veterinary Genetics Laboratory

GTP Name
Veterinary Genetics Laboratory
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7437G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Gentilini, F., Turba, M.E.Two novel real-time PCR methods for genotyping the von Willebrand disease type I mutation in Doberman Pinscher dogs. Vet J 197:457-60, 2013. Pubmed reference: 23911791. DOI: 10.1016/j.tvjl.2013.02.023. (2013)
Inheritance
AR
FCI Number
143
GTP Breed
Doberman Pinscher

VetGen LLC

GTP Name
VetGen LLC
Breed
Gene Name
VWF
Mutation
c.7437G>A

VHL Genetics

GTP Name
VHL Genetics
Breed
Gene Name
VWF
Mutation
c.7437G>A; c.7142C>T

Wisdom Health (formerly Mars Veterinary)

GTP Name
Wisdom Health (formerly Mars Veterinary)
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7142C>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Nichols, T.C., Hough, C., Agers??, H., Ezban, M., Lillicrap, D. : Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies.
Inheritance
AR
FCI Number
143
GTP Breed
Dobermann

Zoolyx

GTP
GTP Name
Zoolyx
Breed
Gene Name
VWF
Mutation
c.7437G>A; c.7142C>T
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