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Von Willebrand Disease I

Breed: Poodle/ Toy

Generic Phene Data

Breeds

General

Disease Name
Von Willebrand Disease I
Mutation
c.7142C>T
Mutation 2
c.7437G>A
Test Type
Genetic Disease/Disorder
Details
Von Willebrand?s disease (vWD) is a blood disease caused by a deficiency of von Willebrand Factor (vWF), an adhesive glycoprotein in the blood required for normal blood clotting. A lack of vWF impairs platelet stickiness and clumping. Symptoms can include: spontaneous hemorrhage from mucosal surfaces, nosebleeds, blood in the faeces, bloody urine, bleeding gums, excessive vaginal bleeding, bruising, prolonged bleeding after surgery or trauma, blood loss anemia. The inheritance of the severe forms (Types II and III) is autosomal recessive. The milder form (Type I) may be autosomal recessive or incompletely dominant. This is the most common hereditary blood clotting disorder in dogs.
Details 2
Von Willebrand?s disease (vWD) is a blood disease caused by a deficiency of von Willebrand Factor (vWF), an adhesive glycoprotein in the blood required for normal blood clotting. A lack of vWF impairs platelet stickiness and clumping. Symptoms can include: spontaneous hemorrhage from mucosal surfaces, nosebleeds, blood in the faeces, bloody urine, bleeding gums, excessive vaginal bleeding, bruising, prolonged bleeding after surgery or trauma, blood loss anemia. The inheritance of the severe forms (Types II and III) is autosomal recessive. The milder form (Type I) may be autosomal recessive or incompletely dominant. This is the most common hereditary blood clotting disorder in dogs.
Published
Brewer, G.J., Venta, P.J., Schall, W., Yuzbasiyan-Gurkan, V., Li, J. : DNA tests for von Willebrand?s disease in Dobermans, Scotties, Shelties and Manchester terriers. Canine Practice 23:45, 1998.

Breed Specific Info

Researched Breeds
Doberman Pincher

Breed Specific Data

Agrotis S.r.l.

GTP Name
Agrotis S.r.l.
Breed
Gene Name
VWF
Mutation
c.7437G>A

Anicom

GTP
GTP Name
Anicom
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7437G>A

BioBank AS

GTP Name
BioBank AS
Breed
Gene Name
VWF
Mutation
c.7437G>A

CAG GmbH Center for Animal Genetics

GTP Name
Center for Animal Genetics
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7437G>A
Nature of test
mutation test
FCI Number
172
GTP Breed
Toy Poodle

Certagen GmbH

GTP Name
Certagen GmbH
Breed
Gene Name
VWF
Mutation
c.7437G>A

CMSCH

GTP
GTP Name
CMSCH
Breed
Gene Name
VWF
Mutation
c.7437G>A

EVG Diagnostics

GTP Name
EVG Molecular Diagnostics
Breed
Gene Name
VWF
Mutation
c.7437G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Am J Vet Res. 2001 Mar;62(3):364-9.

Genomia s.r.o

GTP Name
Genomia s.r.o
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7437G>A
Nature of test
mutation test
FCI Number
172
GTP Breed
Poodle/ Toy

Genoscoper Laboratories Oy

GTP Name
Genoscoper Laboratories Oy
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7437G>A
Nature of test
mutation test
FCI Number
172
GTP Breed
Toy Poodle

GenSol Diagnostics

GTP Name
GenSol Diagnostics
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7437G>A

INNO

GTP
GTP Name
INNO
Breed
Gene Name
VWF
Mutation
c.7437G>A

Laboratorios Labocor S.L.

GTP Name
Laboratorios Labocor S.L.
Breed
Gene Name
VWF
Mutation
c.7437G>A

Laboklin Gmbh & Co. KG

GTP Name
Laboklin Gmbh & Co. KG
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7437G>A
Nature of test
mutation test
FCI Number
172
GTP Breed
Poodle/ Toy

Paw Print Genetics

GTP Name
Paw Print Genetics
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7437G>A
Nature of test
mutation test
FCI Number
172

PharmaDNA

GTP
GTP Name
PharmaDNA
Breed
Gene Name
VWF
Mutation
c.7437G>A

Independent Veterinary Laboratory POISK

GTP Name
Independent Veterinary Laboratory POISK
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7437G>A

Progènes-ADN

GTP Name
Progenes ADN
Breed
Gene Name
VWF
Mutation
c.7437G>A

Veterinary Genetics Laboratory

GTP Name
Veterinary Genetics Laboratory
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7437G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Gentilini, F., Turba, M.E.Two novel real-time PCR methods for genotyping the von Willebrand disease type I mutation in Doberman Pinscher dogs. Vet J 197:457-60, 2013. Pubmed reference: 23911791. DOI: 10.1016/j.tvjl.2013.02.023. (2013)
Inheritance
AR
FCI Number
172
GTP Breed
Toy Poodle

VetGen LLC

GTP Name
VetGen LLC
Breed
Gene Name
VWF
Mutation
c.7437G>A

VHL Genetics

GTP Name
VHL Genetics
Breed
Gene Name
VWF
Mutation
c.7437G>A

Wisdom Health (formerly Mars Veterinary)

GTP Name
Wisdom Health (formerly Mars Veterinary)
Breed
GTP Disease Name
von Willebrand Factor I
Gene Name
VWF
Mutation
c.7437G>A
Nature of test
mutation test
FCI Number
172
GTP Breed
Toy Poodle

Zoolyx

GTP
GTP Name
Zoolyx
Breed
Gene Name
VWF
Mutation
c.7437G>A
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