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Von Willebrand Disease III

Breed: Australian Terrier

Generic Phene Data

Breeds

Relevance Rating: There is some evidence or research available for these breeds

Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful in this breed

General

Disease Name
Von Willebrand Disease III
Mutation
c.264delC
Mutation 2
c.2186+1G>A
Test Type
Genetic Disease/Disorder
Details
Von Willebrand?s disease (vWD) is a blood disease caused by a deficiency of von Willebrand Factor (vWF), an adhesive glycoprotein in the blood required for normal blood clotting. A lack of vWF impairs platelet stickiness and clumping. Symptoms can include: spontaneous hemorrhage from mucosal surfaces, nosebleeds, blood in the faeces, bloody urine, bleeding gums, excessive vaginal bleeding, bruising, prolonged bleeding after surgery or trauma, blood loss anemia. The inheritance of the severe forms (Types II and III) is autosomal recessive. The milder form (Type I) may be autosomal recessive or incompletely dominant. This is the most common hereditary blood clotting disorder in dogs.
Details 2
Von Willebrand?s disease (vWD) is a blood disease caused by a deficiency of von Willebrand Factor (vWF), an adhesive glycoprotein in the blood required for normal blood clotting. A lack of vWF impairs platelet stickiness and clumping. Symptoms can include: spontaneous hemorrhage from mucosal surfaces, nosebleeds, blood in the faeces, bloody urine, bleeding gums, excessive vaginal bleeding, bruising, prolonged bleeding after surgery or trauma, blood loss anemia. The inheritance of the severe forms (Types II and III) is autosomal recessive. The milder form (Type I) may be autosomal recessive or incompletely dominant. This is the most common hereditary blood clotting disorder in dogs.
Published
Rieger, M., Schwarz, H.P., Turecek, P.L., Dorner, F., Vanmourik, J.A., Mannhalter, C. : Identification of mutations in the canine von Willebrand factor gene associated with type III von-Willebrand-disease Thrombosis and Haemostasis 80:332-337, 1998. Pubmed reference: 9716162.

Breed Specific Data

Agrotis S.r.l.

GTP Name
Agrotis S.r.l.
Gene Name
VWF
Mutation
c.2186+1G>A

Anicom

GTP
GTP Name
Anicom
GTP Disease Name
von Willebrand Factor III
Gene Name
VWF
Mutation
c.2186+1G>A

BioBank AS

GTP Name
BioBank AS
Gene Name
VWF
Mutation
c.2186+1G>A

Certagen GmbH

GTP Name
Certagen GmbH
Gene Name
VWF
Mutation
c.2186+1G>A

CMSCH

GTP
GTP Name
CMSCH
Gene Name
VWF
Mutation
c.2186+1G>A

DNA My Dog

GTP Name
DNA My Dog
GTP Disease Name
von Willebrand Factor III
Gene Name
VWF
Mutation
c.2186+1G>A
Nature of test
mutation test
This test is outsourced to:
Orivet
FCI Number
8
GTP Breed
Australian Terrier

INNO

GTP
GTP Name
INNO
Gene Name
VWF
Mutation
c.2186+1G>A

Laboratorios Labocor S.L.

GTP Name
Laboratorios Labocor S.L.
Gene Name
VWF
Mutation
c.2186+1G>A

Orivet Genetic Pet Care

GTP Name
Orivet Genetic Pet Care
GTP Disease Name
von Willebrand Factor III
Gene Name
VWF
Mutation
c.2186+1G>A
Nature of test
mutation test
FCI Number
8
GTP Breed
Australian Terrier

PharmaDNA

GTP
GTP Name
PharmaDNA
Gene Name
VWF
Mutation
c.2186+1G>A

Progènes-ADN

GTP Name
Progenes ADN
Gene Name
VWF
Mutation
c.2186+1G>A

VHL Genetics

GTP Name
VHL Genetics
Gene Name
VWF
Mutation
c.2186+1G>A

Zoolyx

GTP
GTP Name
Zoolyx
Gene Name
VWF
Mutation
c.2186+1G>A
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