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Von Willebrand Disease III

Breed: Nederlandse Kooikerhondje

Generic Phene Data

Breeds

Relevance Rating: There is some evidence or research available for these breeds

Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful in this breed

General

Disease Name
Von Willebrand Disease III
Mutation
c.264delC
Mutation 2
c.2186+1G>A
Test Type
Genetic Disease/Disorder
Details
Von Willebrand?s disease (vWD) is a blood disease caused by a deficiency of von Willebrand Factor (vWF), an adhesive glycoprotein in the blood required for normal blood clotting. A lack of vWF impairs platelet stickiness and clumping. Symptoms can include: spontaneous hemorrhage from mucosal surfaces, nosebleeds, blood in the faeces, bloody urine, bleeding gums, excessive vaginal bleeding, bruising, prolonged bleeding after surgery or trauma, blood loss anemia. The inheritance of the severe forms (Types II and III) is autosomal recessive. The milder form (Type I) may be autosomal recessive or incompletely dominant. This is the most common hereditary blood clotting disorder in dogs.
Details 2
Von Willebrand?s disease (vWD) is a blood disease caused by a deficiency of von Willebrand Factor (vWF), an adhesive glycoprotein in the blood required for normal blood clotting. A lack of vWF impairs platelet stickiness and clumping. Symptoms can include: spontaneous hemorrhage from mucosal surfaces, nosebleeds, blood in the faeces, bloody urine, bleeding gums, excessive vaginal bleeding, bruising, prolonged bleeding after surgery or trauma, blood loss anemia. The inheritance of the severe forms (Types II and III) is autosomal recessive. The milder form (Type I) may be autosomal recessive or incompletely dominant. This is the most common hereditary blood clotting disorder in dogs.
Published
Rieger, M., Schwarz, H.P., Turecek, P.L., Dorner, F., Vanmourik, J.A., Mannhalter, C. : Identification of mutations in the canine von Willebrand factor gene associated with type III von-Willebrand-disease Thrombosis and Haemostasis 80:332-337, 1998. Pubmed reference: 9716162.

Breed Specific Data

Agrotis S.r.l.

GTP Name
Agrotis S.r.l.
Gene Name
VWF
Mutation
c.2186+1G>A

Anicom

GTP
GTP Name
Anicom
GTP Disease Name
von Willebrand Factor III
Gene Name
VWF
Mutation
c.2186+1G>A

BioBank AS

GTP Name
BioBank AS
Gene Name
VWF
Mutation
c.2186+1G>A

CAG GmbH Center for Animal Genetics

GTP Name
Center for Animal Genetics
GTP Disease Name
von Willebrand Factor III
Gene Name
VWF
Mutation
c.2186+1G>A
Nature of test
mutation test
FCI Number
314
GTP Breed
Nederlandse Kooikerhondje

Certagen GmbH

GTP Name
Certagen GmbH
Gene Name
VWF
Mutation
c.2186+1G>A

CMSCH

GTP
GTP Name
CMSCH
Gene Name
VWF
Mutation
c.2186+1G>A

EVG Diagnostics

GTP Name
EVG Molecular Diagnostics
Gene Name
VWF
Mutation
c.2186+1G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Thromb Haemost 1998; 80: 332?7

Genoscoper Laboratories Oy

GTP Name
Genoscoper Laboratories Oy
GTP Disease Name
von Willebrand Factor III
Gene Name
VWF
Mutation
c.2186+1G>A
Nature of test
mutation test
FCI Number
314
GTP Breed
Nederlandse Kooikerhondje

GenSol Diagnostics

GTP Name
GenSol Diagnostics
GTP Disease Name
von Willebrand Factor III
Gene Name
VWF
Mutation
c.2186+1G>A

INNO

GTP
GTP Name
INNO
Gene Name
VWF
Mutation
c.2186+1G>A

Laboratorios Labocor S.L.

GTP Name
Laboratorios Labocor S.L.
Gene Name
VWF
Mutation
c.2186+1G>A

Laboklin Gmbh & Co. KG

GTP Name
Laboklin Gmbh & Co. KG
GTP Disease Name
von Willebrand Factor III
Gene Name
VWF
Mutation
c.2186+1G>A
Nature of test
mutation test
FCI Number
314
GTP Breed
Nederlandse Kooikerhondje

Paw Print Genetics

GTP Name
Paw Print Genetics
GTP Disease Name
von Willebrand Factor III
Gene Name
VWF
Mutation
Point Mutation
Nature of test
mutation test
FCI Number
314
GTP Breed
Nederlandse Kooikerhondje

PharmaDNA

GTP
GTP Name
PharmaDNA
Gene Name
VWF
Mutation
c.2186+1G>A

Progènes-ADN

GTP Name
Progenes ADN
Gene Name
VWF
Mutation
c.2186+1G>A

Veterinary Genetics Laboratory

GTP Name
Veterinary Genetics Laboratory
GTP Disease Name
von Willebrand Factor III
Gene Name
VWF
Mutation
c.2186+1G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Slappendel, R.J., Beijer, E.G.M., Vanleeuwen, M.Type III von-Willebrands-disease in Dutch Kooiker dogs Veterinary Quarterly 20:93-97, 1998. Pubmed reference: 9684296. (1998)
Inheritance
AR
FCI Number
314
GTP Breed
Nederlandse Kooikerhondje

VetGen LLC

GTP Name
VetGen LLC
Gene Name
VWF
Mutation
c.2186+1G>A

VHL Genetics

GTP Name
VHL Genetics
Gene Name
VWF
Mutation
c.2186+1G>A

Wisdom Health (formerly Mars Veterinary)

GTP Name
Wisdom Health (formerly Mars Veterinary)
GTP Disease Name
von Willebrand Factor III
Gene Name
VWF
Mutation
c.2186+1G>A
Nature of test
mutation test
FCI Number
314
GTP Breed
Nederlandse Kooikerhondje

Zoolyx

GTP
GTP Name
Zoolyx
Gene Name
VWF
Mutation
c.2186+1G>A
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