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Von Willebrand Disease III

Breed: Scottish Terrier

Generic Phene Data

Breeds

Relevance Rating: Some evidence for test being meaningful for these breeds

Relevance Rating: Unknown, not evaluated or no evidence for test in this breed

General

Disease Name
Von Willebrand Disease III
Mutation
c.264delC
Mutation 2
c.2186+1G>A
Test Type
Genetic Disease/Disorder
Details
Von Willebrand?s disease (vWD) is a blood disease caused by a deficiency of von Willebrand Factor (vWF), an adhesive glycoprotein in the blood required for normal blood clotting. A lack of vWF impairs platelet stickiness and clumping. Symptoms can include: spontaneous hemorrhage from mucosal surfaces, nosebleeds, blood in the faeces, bloody urine, bleeding gums, excessive vaginal bleeding, bruising, prolonged bleeding after surgery or trauma, blood loss anemia. The inheritance of the severe forms (Types II and III) is autosomal recessive. The milder form (Type I) may be autosomal recessive or incompletely dominant. This is the most common hereditary blood clotting disorder in dogs.
Details 2
Von Willebrand?s disease (vWD) is a blood disease caused by a deficiency of von Willebrand Factor (vWF), an adhesive glycoprotein in the blood required for normal blood clotting. A lack of vWF impairs platelet stickiness and clumping. Symptoms can include: spontaneous hemorrhage from mucosal surfaces, nosebleeds, blood in the faeces, bloody urine, bleeding gums, excessive vaginal bleeding, bruising, prolonged bleeding after surgery or trauma, blood loss anemia. The inheritance of the severe forms (Types II and III) is autosomal recessive. The milder form (Type I) may be autosomal recessive or incompletely dominant. This is the most common hereditary blood clotting disorder in dogs.
Published
Rieger, M., Schwarz, H.P., Turecek, P.L., Dorner, F., Vanmourik, J.A., Mannhalter, C. : Identification of mutations in the canine von Willebrand factor gene associated with type III von-Willebrand-disease Thrombosis and Haemostasis 80:332-337, 1998. Pubmed reference: 9716162.

Breed Specific Data

Agrotis S.r.l.

GTP Name
Agrotis S.r.l.
Gene Name
VWF
Mutation
c.264delC

Anicom

GTP
GTP Name
Anicom
Gene Name
VWF
Mutation
c.264delC

Antagene

GTP
GTP Name
Antagene
Gene Name
VWF
Mutation
c.264delC
Inheritance
AR
GTP Breed
Scottish Terrier

BioBank AS

GTP Name
BioBank AS
Gene Name
VWF
Mutation
c.264delC

CAG GmbH Center for Animal Genetics

GTP Name
Center for Animal Genetics
Gene Name
VWF
Mutation
c.264delC
Inheritance
AR
GTP Breed
Scottish Terrier

Certagen GmbH

GTP Name
Certagen GmbH
Gene Name
VWF
Mutation
c.264delC

CMSCH

GTP
GTP Name
CMSCH
Gene Name
VWF
Mutation
c.264delC

DNA My Dog

GTP Name
DNA My Dog
Gene Name
VWF
Mutation
c.264delC
Inheritance
AR
GTP Breed
Scottish Terrier

Embark

GTP
GTP Name
Embark
Gene Name
VWF
Mutation
c.264delC
Inheritance
AR
GTP Breed
Scottish Terrier

EVG Diagnostics

GTP Name
EVG Molecular Diagnostics
Gene Name
VWF
Mutation
c.264delC

Genoscoper Laboratories Oy

GTP Name
Genoscoper Laboratories Oy
Gene Name
VWF
Mutation
c.264delC
Inheritance
AR
GTP Breed
Scottish Terrier

GenSol Diagnostics

GTP Name
GenSol Diagnostics
Gene Name
VWF
Mutation
c.264delC

INNO

GTP
GTP Name
INNO
Gene Name
VWF
Mutation
c.264delC

Laboratorios Labocor S.L.

GTP Name
Laboratorios Labocor S.L.
Gene Name
VWF
Mutation
c.264delC

Laboklin Gmbh & Co. KG

GTP Name
Laboklin Gmbh & Co. KG
Gene Name
VWF
Mutation
c.264delC
Inheritance
AR
GTP Breed
Scottish Terrier

Orivet Genetic Pet Care

GTP Name
Orivet Genetic Pet Care
Gene Name
VWF
Mutation
c.264delC
Inheritance
AR
GTP Breed
Scottish Terrier

Paw Print Genetics

GTP Name
Paw Print Genetics
Gene Name
VWF
Mutation
Deletion

PharmaDNA

GTP
GTP Name
PharmaDNA
Gene Name
VWF
Mutation
c.264delC

Progènes-ADN

GTP Name
Progenes ADN
Gene Name
VWF
Mutation
c.264delC

Veterinary Genetics Laboratory

GTP Name
Veterinary Genetics Laboratory
Gene Name
VWF
Mutation
c.264delC
Inheritance
AR
GTP Breed
Scottish Terrier

VetGen LLC

GTP Name
VetGen LLC
Gene Name
VWF
Mutation
c.264delC

VHL Genetics

GTP Name
VHL Genetics
Gene Name
VWF
Mutation
c.264delC

Wisdom Health (formerly Mars Veterinary)

GTP Name
Wisdom Health (formerly Mars Veterinary)
Gene Name
VWF
Mutation
c.264delC
Inheritance
AR
GTP Breed
Scottish Terrier

Zoolyx

GTP
GTP Name
Zoolyx
Gene Name
VWF
Mutation
c.264delC
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