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Cleft Lip with or without Cleft Palate

Breed: Nova Scotia duck tolling Retriever

Generic Phene Data

Breeds

Relevance Rating: There is some evidence or research available in this breed

General

Disease Name
Cleft Lip with or without Cleft Palate
Mutation
c.1360_1361delAA
Test Type
Genetic Disease/Disorder
Details
A cleft palate is an abnormal opening in the roof of the mouth. It is the result of failure of the two sides of the palate (roof of the mouth) to come together and fuse during embryonic development. A cleft palate results in an opening between the nasal passages and the mouth. Symptoms expected with a cleft palate include: runny nose, coughing, aspiration pneumonia (pneumonia caused by milk and food contents entering the cleft and infecting the lungs), respiratory difficulty (caused by aspiration pneumonia), difficulty sucking and nursing (for puppies), slow growth, weight loss, lack of appetite. Cleft palates can be inherited, and also have non-inherited causes, such as environmental effects - i.e. vitamin deficencies.
Details 2
Cleft lip (often referred to incorrectly as a ?hair lip? or more appropriately as palatoschisis or congenital oronasal fistula) and cleft palate are birth defects that occur when a puppy's lip or mouth do not form properly during pregnancy. Symptoms with a cleft palate can include: runny nose, coughing, aspiration pneumonia, respiratory difficulty (caused by aspiration pneumonia), difficulty sucking and nursing, slow growth, weight loss, lack of appetite. Cleft palates can be inherited, and also have non-inherited causes, such as environmental effects.
Published
Wolf, Z.T., Brand, H.A., Shaffer, J.R., Leslie, E.J., Arzi, B., Willet, C.E., Cox, T.C., McHenry, T., Narayan, N., Feingold, E., Wang, X., Sliskovic, S., Karmi, N., Safra, N., Sanchez, C., Deleyiannis, F.W., Murray, J.C., Wade, C.M., Marazita, M.L., Bannasch, D.L. : Genome-wide association studies in dogs and humans identify ADAMTS20 as a risk variant for cleft lip and palate. PLoS Genet 11:e1005059, 2015. Pubmed reference: 25798845. DOI: 10.1371/journal.pgen.1005059.

Breed Specific Data

CAG GmbH Center for Animal Genetics

GTP Name
Center for Animal Genetics
Gene Name
ADAMTS20
Mutation
c.1360_1361delAA
Nature of test
mutation test
GTP- or Breed-Specific Publications
Wolf, Z.T., Brand, H.A., Shaffer, J.R., Leslie, E.J., Arzi, B., Willet, C.E., Cox, T.C., McHenry, T., Narayan, N., Feingold, E., Wang, X., Sliskovic, S., Karmi, N., Safra, N., Sanchez, C., Deleyiannis
Inheritance
AR
FCI Number
312
GTP Breed
Nova Scotia duck tolling Retriever

Genoscoper Laboratories Oy

GTP Name
Genoscoper Laboratories Oy
Gene Name
ADAMTS20
Mutation
c.1360_1361delAA
Nature of test
mutation test
GTP- or Breed-Specific Publications
Wolf, Z.T., Brand, H.A., Shaffer, J.R., Leslie, E.J., Arzi, B., Willet, C.E., Cox, T.C., McHenry, T., Narayan, N., Feingold, E., Wang, X., Sliskovic, S., Karmi, N., Safra, N., Sanchez, C., Deleyiannis
Inheritance
AR
FCI Number
312
GTP Breed
Nova Scotia duck tolling Retriever

Laboklin Gmbh & Co. KG

GTP Name
Laboklin Gmbh & Co. KG
Gene Name
ADAMTS20
Mutation
c.1360_1361delAA
Nature of test
mutation test
FCI Number
312

Orivet Genetic Pet Care

GTP Name
Orivet Genetic Pet Care
Gene Name
ADAMTS20
Mutation
c.1360_1361delAA
Nature of test
mutation test
GTP- or Breed-Specific Publications
Wolf, Z.T., Brand, H.A., Shaffer, J.R., Leslie, E.J., Arzi, B., Willet, C.E., Cox, T.C., McHenry, T., Narayan, N., Feingold, E., Wang, X., Sliskovic, S., Karmi, N., Safra, N., Sanchez, C., Deleyiannis
Inheritance
AR
FCI Number
312
GTP Breed
Nova Scotia duck tolling Retriever

Veterinary Genetics Laboratory

GTP Name
Veterinary Genetics Laboratory
Gene Name
ADAMTS20
Mutation
c.1360_1361delAA
Nature of test
mutation test
GTP- or Breed-Specific Publications
Wolf ZT, Brand HA, Shaffer JR, Leslie EJ, Arzi B, Willet CE, Cox TC, McHenry T, Narayan N, Feingold E, Wang X, Sliskovic S, Karmi N, Safra N, Sanchez C, Deleyiannis FW, Murray JC, Wade CM, Marazita ML, Bannasch DL. Genome-wide association studies in dogs
Inheritance
AR
FCI Number
312
GTP Breed
Nova Scotia duck tolling Retriever

Wisdom Health (formerly Mars Veterinary)

GTP Name
Wisdom Health (formerly Mars Veterinary)
Gene Name
ADAMTS20
Mutation
c.1360_1361delAA
Nature of test
mutation test
GTP- or Breed-Specific Publications
Wolf, Z.T., Brand, H.A., Shaffer, J.R., Leslie, E.J., Arzi, B., Willet, C.E., Cox, T.C., McHenry, T., Narayan, N., Feingold, E., Wang, X., Sliskovic, S., Karmi, N., Safra, N., Sanchez, C., Deleyiannis
Inheritance
AR
FCI Number
312
GTP Breed
Nova Scotia duck tolling Retriever

DNA My Dog

GTP Name
DNA My Dog
Gene Name
ADAMTS20
Mutation
c.1360_1361delAA
Nature of test
mutation test
GTP- or Breed-Specific Publications
Wolf, Z.T., Brand, H.A., Shaffer, J.R., Leslie, E.J., Arzi, B., Willet, C.E., Cox, T.C., McHenry, T., Narayan, N., Feingold, E., Wang, X., Sliskovic, S., Karmi, N., Safra, N., Sanchez, C., Deleyiannis
Inheritance
AR
This test is outsourced to:
Orivet
FCI Number
312
GTP Breed
Nova Scotia duck tolling Retriever
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