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Polyneuropathy - NDRG1 Type (AMPN)

Breed: Alaskan Malamute

Generic Phene Data

General

Disease Name
Polyneuropathy - NDRG1 Type (AMPN)
Disease Name 2
Polyneuropathy - Alaskan Malamute Type
OMIA
1292
Gene Name
NDRG1
Mutation
c.1080_1089delTCGCCTGGAC
Mutation 2
c.293G>T
Mutation 3
Gly98Val
OMIM
601455
Disease Code
P
Test Type
Genetic Disease/Disorder
Details
Polyneuropathy describes many abnormalities of the nervous system including sensory nerves, motor nerves, and autonomic nerves. Signs include progressive weakness, exercise intolerance, high-steppage, change in bark pitch and difficulty breathing. Age of onset 7 to 20 months of age. Symptoms can be progressive.
Published
Drogemuller, C., Becker, D., Kessler, B., Kemter, E., Tetens, J., Jurina, K., Jaderlund, KH., Flagstad, A., Perloski, M., Lindblad-Toh, K., Matiasek, K. : A deletion in the N-myc downstream regulated gene 1 (NDRG1) gene in Greyhounds with polyneuropathy. PLoS One 5:e11258, 2010. Pubmed reference: 20582309. DOI: 10.1371/journal.pone.0011258.
Published 2
Bruun, C.S., Juderlund, K.H., Berendt, M., Jensen, K.B., Spodsberg, E.H., Gredal, H., Shelton, G.D., Mickelson, J.R., Minor, K.M., Lohi, H., Bjerkas, I., Stigen, O., Espenes, A., Rohdin, C., Edlund, R., Ohlsson, J., Cizinauskas, S., Leifsson, P.S., Drogemuller, C., Moe, L., Cirera, S., Fredholm, M. : A Gly98Val Mutation in the N-Myc Downstream Regulated Gene 1 (NDRG1) in Alaskan Malamutes with Polyneuropathy. PLoS One 8:e54547, 2013. Pubmed reference: 23393557. DOI: 10.1371/journal.pone.0054547.
Body/System/Process
Neurologic
Inheritance
AR
Gene Name Text
N-myc downstream regulated 1

Breed Specific Data

VetGen LLC

Link to GTP
Gene Name
NDRG1
Mutation
c.293G>T

DNA My Dog

Link to GTP
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.293G>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Bruun, C.S., Jäderlund, K.H., Berendt, M., Jensen, K.B., Spodsberg, E.H., Gredal, H., Shelton, G.D., Mickelson, J.R., Minor, K.M., Lohi, H., Bjerk
Application in the Breed
Carriers can be bred to normal animals (N/p x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/p x N/p) nor affected animals (p/p) .Chronic, progressive disease with clinical signs between 7-18 months of age. Symptoms: exercise intolerance , gait abnormalities l --> para- or tetraparesis, muscle atrophy, laryngeal paralysis.
Inheritance
AR

University of Minnesota Canine Genetics Lab

Link to GTP
GTP Disease Name
Alaskan Malamute Polyneuropathy
Gene Name
NDRG1
Mutation
Gly98Val
Mutation Comment
Gly98Val
Application in the Breed
A Gly98Val Mutation in the N-Myc Downstream Regulated Gene 1 (NDRG1) in Alaskan Malamutes with Polyneuropathy. Bruun CS, Jäderlund KH, Berendt M, Jensen KB, Spodsberg EH, Gredal H, et al. (2013), PLoS ONE 8(2): e54547.doi:10.1371/journal.pone.0054547

Wisdom Health (formerly Mars Veterinary)

Link to GTP
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.293G>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Bruun, C.S., Jäderlund, K.H., Berendt, M., Jensen, K.B., Spodsberg, E.H., Gredal, H., Shelton, G.D., Mickelson, J.R., Minor, K.M., Lohi, H., Bjerk
Application in the Breed
Carriers can be bred to normal animals (N/p x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/p x N/p) nor affected animals (p/p) .Chronic, progressive disease with clinical signs between 7-18 months of age. Symptoms: exercise intolerance , gait abnormalities l --> para- or tetraparesis, muscle atrophy, laryngeal paralysis.
Inheritance
AR

Veterinary Genetics Laboratory

Link to GTP
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.293G>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Bruun CS, KH Jäderlund, M Berendt et al. 2013. A Gly98Val mutation in the N-Myc downstream regulated gene 1 (NDRG1) in Alaskan Malamutes with Polyneuropathy. PLoS ONE 8(2): e54547. doi:10.1371/journal.pone.0054547.
Application in the Breed
Carriers can be bred to normal animals (N/p x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/p x N/p) nor affected animals (p/p) .Chronic, progressive disease with clinical signs between 7-18 months of age. Symptoms: exercise intolerance , gait abnormalities l --> para- or tetraparesis, muscle atrophy, laryngeal paralysis.
Inheritance
AR

Paw Print Genetics

Link to GTP
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.293G>T
Nature of test
mutation test

Orivet Genetic Pet Care

Link to GTP
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.293G>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Bruun, C.S., Jäderlund, K.H., Berendt, M., Jensen, K.B., Spodsberg, E.H., Gredal, H., Shelton, G.D., Mickelson, J.R., Minor, K.M., Lohi, H., Bjerk
Application in the Breed
Carriers can be bred to normal animals (N/p x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/p x N/p) nor affected animals (p/p) .Chronic, progressive disease with clinical signs between 7-18 months of age. Symptoms: exercise intolerance , gait abnormalities l --> para- or tetraparesis, muscle atrophy, laryngeal paralysis.
Inheritance
AR

Laboklin Gmbh & Co. KG

Link to GTP
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.293G>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Bruun, C.S., Jäderlund, K.H., Berendt, M., Jensen, K.B., Spodsberg, E.H., Gredal, H., Shelton, G.D., Mickelson, J.R., Minor, K.M., Lohi, H., Bjerk
Application in the Breed
Carriers can be bred to normal animals (N/p x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/p x N/p) nor affected animals (p/p) .Chronic, progressive disease with clinical signs between 7-18 months of age. Symptoms: exercise intolerance , gait abnormalities l --> para- or tetraparesis, muscle atrophy, laryngeal paralysis.
Inheritance
AR

Genoscoper Laboratories Oy

Link to GTP
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.293G>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Bruun, C.S., Jäderlund, K.H., Berendt, M., Jensen, K.B., Spodsberg, E.H., Gredal, H., Shelton, G.D., Mickelson, J.R., Minor, K.M., Lohi, H., Bjerk
Application in the Breed
Carriers can be bred to normal animals (N/p x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/p x N/p) nor affected animals (p/p) .Chronic, progressive disease with clinical signs between 7-18 months of age. Symptoms: exercise intolerance , gait abnormalities l --> para- or tetraparesis, muscle atrophy, laryngeal paralysis.
Inheritance
AR

Genomia s.r.o

Link to GTP
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.293G>T
Nature of test
mutation test

EVG Diagnostics

Link to GTP
Gene Name
NDRG1
Mutation
c.293G>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
PLoS One. 2013;8(2):e54547

Embark

Link to GTP
GTP
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.293G>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Bruun, C.S., Jäderlund, K.H., Berendt, M., Jensen, K.B., Spodsberg, E.H., Gredal, H., Shelton, G.D., Mickelson, J.R., Minor, K.M., Lohi, H., Bjerk
Application in the Breed
Carriers can be bred to normal animals (N/p x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/p x N/p) nor affected animals (p/p) .Chronic, progressive disease with clinical signs between 7-18 months of age. Symptoms: exercise intolerance , gait abnormalities l --> para- or tetraparesis, muscle atrophy, laryngeal paralysis.
Inheritance
AR

CAG GmbH Center for Animal Genetics

Link to GTP
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.293G>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Bruun, C.S., Jäderlund, K.H., Berendt, M., Jensen, K.B., Spodsberg, E.H., Gredal, H., Shelton, G.D., Mickelson, J.R., Minor, K.M., Lohi, H., Bjerk
Application in the Breed
Carriers can be bred to normal animals (N/p x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/p x N/p) nor affected animals (p/p) .Chronic, progressive disease with clinical signs between 7-18 months of age. Symptoms: exercise intolerance , gait abnormalities l --> para- or tetraparesis, muscle atrophy, laryngeal paralysis.
Inheritance
AR

Antagene

Link to GTP
GTP
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.293G>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Bruun, C.S., Jäderlund, K.H., Berendt, M., Jensen, K.B., Spodsberg, E.H., Gredal, H., Shelton, G.D., Mickelson, J.R., Minor, K.M., Lohi, H., Bjerk
Application in the Breed
Carriers can be bred to normal animals (N/p x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/p x N/p) nor affected animals (p/p) .Chronic, progressive disease with clinical signs between 7-18 months of age. Symptoms: exercise intolerance , gait abnormalities l --> para- or tetraparesis, muscle atrophy, laryngeal paralysis.
Inheritance
AR
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