Jump to content
International Collaboration For Dog Health And Welfare. Join Us.

Polyneuropathy - NDRG1 Type (AMPN)

Breed: St. Bernard/ Longhaired

Generic Phene Data

General

Disease Name
Polyneuropathy - NDRG1 Type (AMPN)
Disease Name 2
Polyneuropathy - Alaskan Malamute Type
OMIA
1292
Gene Name
NDRG1
Mutation
c.1080_1089delTCGCCTGGAC
Mutation 2
c.293G>T
Mutation 3
Gly98Val
OMIM
601455
Disease Code
P
Test Type
Genetic Disease/Disorder
Details
Polyneuropathy describes many abnormalities of the nervous system including sensory nerves, motor nerves, and autonomic nerves. Signs include progressive weakness, exercise intolerance, high-steppage, change in bark pitch and difficulty breathing. Age of onset 7 to 20 months of age. Symptoms can be progressive.
Published
Drogemuller, C., Becker, D., Kessler, B., Kemter, E., Tetens, J., Jurina, K., Jaderlund, KH., Flagstad, A., Perloski, M., Lindblad-Toh, K., Matiasek, K. : A deletion in the N-myc downstream regulated gene 1 (NDRG1) gene in Greyhounds with polyneuropathy. PLoS One 5:e11258, 2010. Pubmed reference: 20582309. DOI: 10.1371/journal.pone.0011258.
Published 2
Bruun, C.S., Juderlund, K.H., Berendt, M., Jensen, K.B., Spodsberg, E.H., Gredal, H., Shelton, G.D., Mickelson, J.R., Minor, K.M., Lohi, H., Bjerkas, I., Stigen, O., Espenes, A., Rohdin, C., Edlund, R., Ohlsson, J., Cizinauskas, S., Leifsson, P.S., Drogemuller, C., Moe, L., Cirera, S., Fredholm, M. : A Gly98Val Mutation in the N-Myc Downstream Regulated Gene 1 (NDRG1) in Alaskan Malamutes with Polyneuropathy. PLoS One 8:e54547, 2013. Pubmed reference: 23393557. DOI: 10.1371/journal.pone.0054547.
Body/System/Process
Neurologic
Inheritance
AR
Gene Name Text
N-myc downstream regulated 1

Breed Specific Data

Animal Health Trust (UK)

Link to GTP
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.1080_1089delTCGCCTGGAC
Nature of test
mutation test

DNA My Dog

Link to GTP
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.1080_1089delTCGCCTGGAC
Nature of test
mutation test

Orivet Genetic Pet Care

Link to GTP
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.1080_1089delTCGCCTGGAC
Nature of test
mutation test
×
×
  • Create New...

Important Information

By using this site, you agree to our Terms of Use.