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Hereditary Footpad Hyperkeratosis

Breed: Dogue de Bordeaux

Generic Phene Data

Breeds

Relevance Rating: Moderate evidence for test being meaningful in this breed

Relevance Rating: Unknown, not evaluated or no evidence for test for these breeds

General

Disease Name
Hereditary Footpad Hyperkeratosis
Mutation
c.155G>C
Mutation 2
unpublished
Test Type
Genetic Disease/Disorder
Details
Hereditary footpad hyperkeratosis (HFH), sometimes described as ?corny feet? initially leads to thickened and hardened footpads. Age of onset from 18 to 24 weeks. The hardened and thickened pad surface later develops cracks and fissures, which can cause secondary infections. Untreated, HFH can lead to considerable pain and lameness in affected dogs.
Details 2
Epidermolytic palmoplantar keratoderma (EPPK) is an inherited disorder characterized by abnormal thickening of the palmoplantar epidermis... Hereditary footpad hyperkeratosis (HFH, also known as digital hyperkeratosis (DH) or ?corny feet?) is a specific form of an orthokeratotic palmoplantar hyperkeratosis... HFH initially leads to thickened and hardened footpads, which can be recognized in juvenile dogs starting at an age of 18 to 24 weeks. The inelastic pad surface subsequently develops cracks and fissures, which predispose affected dogs to secondary infections. If not properly managed, HFH can thus lead to considerable pain and lameness in affected dogs. (From Drogemuller et al, 2014)
Published
Drogemuller, M., Jagannathan, V., Becker, D., Drogemuller, C., Schelling, C., Plassais, J., Kaerle, C., Dufaure de Citres, C., Thomas, A., Muller, E.J., Welle, M.M., Roosje, P., Leeb, T. : A mutation in the FAM83G gene in dogs with hereditary footpad hyperkeratosis (HFH). PLoS Genet 10:e1004370, 2014. Pubmed reference: 24832243. DOI: 10.1371/journal.pgen.1004370.

Breed Specific Data

Antagene

GTP
GTP Name
Antagene
Gene Name
KRT16
Mutation
unpublished
Inheritance
AR
GTP Breed
Dogue de Bordeaux

Laboklin Gmbh & Co. KG

GTP Name
Laboklin Gmbh & Co. KG
Gene Name
KRT16
Mutation
unpublished
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