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Von Willebrand Disease II

Breed: Bobtail/ Old English Sheepdog

Generic Phene Data

General

Disease Name
Von Willebrand Disease II
Mutation
G>A in a2 domain
Mutation 2
A>G in a2 domain
Mutation 3
c.4937A>G
Test Type
Genetic Disease/Disorder
Details
Von Willebrand?s disease (vWD) is a blood disease caused by a deficiency of von Willebrand Factor (vWF), an adhesive glycoprotein in the blood required for normal blood clotting. A lack of vWF impairs platelet stickiness and clumping. Symptoms can include: spontaneous hemorrhage from mucosal surfaces, nosebleeds, blood in the faeces, bloody urine, bleeding gums, excessive vaginal bleeding, bruising, prolonged bleeding after surgery or trauma, blood loss anemia. The inheritance of the severe forms (Types II and III) is autosomal recessive. The milder form (Type I) may be autosomal recessive or incompletely dominant. This is the most common hereditary blood clotting disorder in dogs.
Details 2
Von Willebrand?s disease (vWD) is a blood disease caused by a deficiency of von Willebrand Factor (vWF), an adhesive glycoprotein in the blood required for normal blood clotting. A lack of vWF impairs platelet stickiness and clumping. Symptoms can include: spontaneous hemorrhage from mucosal surfaces, nosebleeds, blood in the faeces, bloody urine, bleeding gums, excessive vaginal bleeding, bruising, prolonged bleeding after surgery or trauma, blood loss anemia. The inheritance of the severe forms (Types II and III) is autosomal recessive. The milder form (Type I) may be autosomal recessive or incompletely dominant. This is the most common hereditary blood clotting disorder in dogs.
Published
Kramer, JW., Venta, PJ., Klein, SR., Cao, Y., Schall, WD., Yuzbasiyan-Gurkan, V. : A von Willebrand's factor genomic nucleotide variant and polymerase chain reaction diagnostic test associated with inheritable type-2 von Willebrand's disease in a line of german shorthaired pointer dogs. Vet Pathol 41:221-8, 2004. Pubmed reference: 15133170. DOI: 10.1354/vp.41-3-221.

Breed Specific Data

Zoolyx

GTP
GTP Name
Zoolyx
Gene Name
VWF
Mutation
G>A in a2 domain

Progènes-ADN

GTP Name
Progenes ADN
Gene Name
VWF
Mutation
G>A in a2 domain

PharmaDNA

GTP
GTP Name
PharmaDNA
Gene Name
VWF
Mutation
G>A in a2 domain

Laboratorios Labocor S.L.

GTP Name
Laboratorios Labocor S.L.
Gene Name
VWF
Mutation
G>A in a2 domain

INNO

GTP
GTP Name
INNO
Gene Name
VWF
Mutation
G>A in a2 domain

CMSCH

GTP
GTP Name
CMSCH
Gene Name
VWF
Mutation
G>A in a2 domain

BioBank AS

GTP Name
BioBank AS
Gene Name
VWF
Mutation
G>A in a2 domain

Agrotis S.r.l.

GTP Name
Agrotis S.r.l.
Gene Name
VWF
Mutation
G>A in a2 domain

Anicom

GTP
GTP Name
Anicom
Gene Name
VWF
Mutation
G>A in a2 domain

Certagen GmbH

GTP Name
Certagen GmbH
Gene Name
VWF
Mutation
G>A in a2 domain

VHL Genetics

GTP Name
VHL Genetics
Gene Name
VWF
Mutation
G>A in a2 domain

CAG GmbH Center for Animal Genetics

GTP Name
Center for Animal Genetics
Gene Name
VWF
Mutation
G>A in a2 domain
Nature of test
mutation test
GTP- or Breed-Specific Publications
Donner, J., Kaukonen, M., Anderson, H., Móller, F., Kyóstilä, K., Sankari, S., Hytónen, M., Giger, U., Lohi, H. : Genetic Panel Screening of Nearly 100 Mutations Reveals New Insights into the Breed Di
Inheritance
AR
FCI Number
16
GTP Breed
Bobtail
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