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Von Willebrand Disease II

Breed: Collies

Generic Phene Data

General

Disease Name
Von Willebrand Disease II
Mutation
G>A in a2 domain
Mutation 2
A>G in a2 domain
Mutation 3
c.4937A>G
Test Type
Genetic Disease/Disorder
Details
Von Willebrand?s disease (vWD) is a blood disease caused by a deficiency of von Willebrand Factor (vWF), an adhesive glycoprotein in the blood required for normal blood clotting. A lack of vWF impairs platelet stickiness and clumping. Symptoms can include: spontaneous hemorrhage from mucosal surfaces, nosebleeds, blood in the faeces, bloody urine, bleeding gums, excessive vaginal bleeding, bruising, prolonged bleeding after surgery or trauma, blood loss anemia. The inheritance of the severe forms (Types II and III) is autosomal recessive. The milder form (Type I) may be autosomal recessive or incompletely dominant. This is the most common hereditary blood clotting disorder in dogs.
Details 2
Von Willebrand?s disease (vWD) is a blood disease caused by a deficiency of von Willebrand Factor (vWF), an adhesive glycoprotein in the blood required for normal blood clotting. A lack of vWF impairs platelet stickiness and clumping. Symptoms can include: spontaneous hemorrhage from mucosal surfaces, nosebleeds, blood in the faeces, bloody urine, bleeding gums, excessive vaginal bleeding, bruising, prolonged bleeding after surgery or trauma, blood loss anemia. The inheritance of the severe forms (Types II and III) is autosomal recessive. The milder form (Type I) may be autosomal recessive or incompletely dominant. This is the most common hereditary blood clotting disorder in dogs.
Published
Kramer, JW., Venta, PJ., Klein, SR., Cao, Y., Schall, WD., Yuzbasiyan-Gurkan, V. : A von Willebrand's factor genomic nucleotide variant and polymerase chain reaction diagnostic test associated with inheritable type-2 von Willebrand's disease in a line of german shorthaired pointer dogs. Vet Pathol 41:221-8, 2004. Pubmed reference: 15133170. DOI: 10.1354/vp.41-3-221.

Breed Specific Info

Researched Breeds
Chinese Crested Dog, German Shorthair Pointer, German Wirehaired Pointer

Breed Specific Data

Zoolyx

GTP
GTP Name
Zoolyx
Breed
Gene Name
VWF
Mutation
A>G in a2 domain; G>A in a2 domain

Progènes-ADN

GTP Name
Progenes ADN
Breed
Gene Name
VWF
Mutation
A>G in a2 domain; G>A in a2 domain

PharmaDNA

GTP
GTP Name
PharmaDNA
Breed
Gene Name
VWF
Mutation
A>G in a2 domain; G>A in a2 domain

Laboratorios Labocor S.L.

GTP Name
Laboratorios Labocor S.L.
Breed
Gene Name
VWF
Mutation
A>G in a2 domain; G>A in a2 domain

INNO

GTP
GTP Name
INNO
Breed
Gene Name
VWF
Mutation
A>G in a2 domain; G>A in a2 domain

CMSCH

GTP
GTP Name
CMSCH
Breed
Gene Name
VWF
Mutation
A>G in a2 domain; G>A in a2 domain

BioBank AS

GTP Name
BioBank AS
Breed
Gene Name
VWF
Mutation
A>G in a2 domain; G>A in a2 domain

Agrotis S.r.l.

GTP Name
Agrotis S.r.l.
Breed
Gene Name
VWF
Mutation
A>G in a2 domain; G>A in a2 domain

Anicom

GTP
GTP Name
Anicom
Breed
Gene Name
VWF
Mutation
G>A in a2 domain

DNA My Dog

GTP Name
DNA My Dog
Breed
Gene Name
VWF
Mutation
G>A in a2 domain
Nature of test
mutation test
GTP- or Breed-Specific Publications
Nichols, T.C., Hough, C., Agers??, H., Ezban, M., Lillicrap, D. : Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies.
Inheritance
AR
This test is outsourced to:
Orivet
FCI Number
-70
GTP Breed
Rough and Smooth Collie

Certagen GmbH

GTP Name
Certagen GmbH
Breed
Gene Name
VWF
Mutation
A>G in a2 domain; G>A in a2 domain

GenSol Diagnostics

GTP Name
GenSol Diagnostics
Breed
Gene Name
VWF
Mutation
A>G in a2 domain

VHL Genetics

GTP Name
VHL Genetics
Breed
Gene Name
VWF
Mutation
A>G in a2 domain; G>A in a2 domain

Orivet Genetic Pet Care

GTP Name
Orivet Genetic Pet Care
Breed
Gene Name
VWF
Mutation
G>A in a2 domain
Nature of test
mutation test
GTP- or Breed-Specific Publications
Nichols, T.C., Hough, C., Agers??, H., Ezban, M., Lillicrap, D. : Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies.
Inheritance
AR
FCI Number
-70
GTP Breed
Rough and Smooth Collie

Antagene

GTP
GTP Name
Antagene
Breed
Gene Name
VWF
Mutation
A>G in a2 domain
Nature of test
mutation test
Inheritance
AR
FCI Number
-70
GTP Breed
Collie
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