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Von Willebrand Disease II

Breed: German longhaired pointing dog/ Deutsch Langhaar

Generic Phene Data

General

Disease Name
Von Willebrand Disease II
Mutation
G>A in a2 domain
Mutation 2
A>G in a2 domain
Mutation 3
c.4937A>G
Test Type
Genetic Disease/Disorder
Details
Von Willebrand?s disease (vWD) is a blood disease caused by a deficiency of von Willebrand Factor (vWF), an adhesive glycoprotein in the blood required for normal blood clotting. A lack of vWF impairs platelet stickiness and clumping. Symptoms can include: spontaneous hemorrhage from mucosal surfaces, nosebleeds, blood in the faeces, bloody urine, bleeding gums, excessive vaginal bleeding, bruising, prolonged bleeding after surgery or trauma, blood loss anemia. The inheritance of the severe forms (Types II and III) is autosomal recessive. The milder form (Type I) may be autosomal recessive or incompletely dominant. This is the most common hereditary blood clotting disorder in dogs.
Details 2
Von Willebrand?s disease (vWD) is a blood disease caused by a deficiency of von Willebrand Factor (vWF), an adhesive glycoprotein in the blood required for normal blood clotting. A lack of vWF impairs platelet stickiness and clumping. Symptoms can include: spontaneous hemorrhage from mucosal surfaces, nosebleeds, blood in the faeces, bloody urine, bleeding gums, excessive vaginal bleeding, bruising, prolonged bleeding after surgery or trauma, blood loss anemia. The inheritance of the severe forms (Types II and III) is autosomal recessive. The milder form (Type I) may be autosomal recessive or incompletely dominant. This is the most common hereditary blood clotting disorder in dogs.
Published
Kramer, JW., Venta, PJ., Klein, SR., Cao, Y., Schall, WD., Yuzbasiyan-Gurkan, V. : A von Willebrand's factor genomic nucleotide variant and polymerase chain reaction diagnostic test associated with inheritable type-2 von Willebrand's disease in a line of german shorthaired pointer dogs. Vet Pathol 41:221-8, 2004. Pubmed reference: 15133170. DOI: 10.1354/vp.41-3-221.

Breed Specific Info

Researched Breeds
Chinese Crested Dog, German Shorthair Pointer, German Wirehaired Pointer

Breed Specific Data

Agrotis S.r.l.

GTP Name
Agrotis S.r.l.
Gene Name
VWF
Mutation
Point Mutation

Anicom

GTP
GTP Name
Anicom
Gene Name
VWF
Mutation
Point Mutation

BioBank AS

GTP Name
BioBank AS
Gene Name
VWF
Mutation
Point Mutation

Certagen GmbH

GTP Name
Certagen GmbH
Gene Name
VWF
Mutation
Point Mutation

CMSCH

GTP
GTP Name
CMSCH
Gene Name
VWF
Mutation
Point Mutation

GenSol Diagnostics

GTP Name
GenSol Diagnostics
Gene Name
VWF
Mutation
Point Mutation

INNO

GTP
GTP Name
INNO
Gene Name
VWF
Mutation
Point Mutation

Laboratorios Labocor S.L.

GTP Name
Laboratorios Labocor S.L.
Gene Name
VWF
Mutation
Point Mutation

Paw Print Genetics

GTP Name
Paw Print Genetics
Gene Name
VWF
Mutation
Point Mutation
Nature of test
mutation test
FCI Number
117

PharmaDNA

GTP
GTP Name
PharmaDNA
Gene Name
VWF
Mutation
Point Mutation

Progènes-ADN

GTP Name
Progenes ADN
Gene Name
VWF
Mutation
Point Mutation

VetGen LLC

GTP Name
VetGen LLC
Gene Name
VWF
Mutation
G>A in a2 domain

VHL Genetics

GTP Name
VHL Genetics
Gene Name
VWF
Mutation
Point Mutation

Zoolyx

GTP
GTP Name
Zoolyx
Gene Name
VWF
Mutation
Point Mutation
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