Reminder: Login to access new features and members-only content!

Register to be a member of our community. Its easy!

Register a new account

Already a member?

Log In here!

Donate

Did you find our content interesting or helpful? Help support the IPFD enhance health, well-being and welfare for dogs everywhere.

Jump to content
  •   Language
  • Sign Up

International Partnership for Dogs - Enhancing Dog Health, Well-Being, and Welfare - Join Us.

Von Willebrand Disease II

Breed: German wirehaired pointing dog/ Deutsch Drahthaar

Generic Phene Data

General

Disease Name
Von Willebrand Disease II
Mutation
G>A in a2 domain
Mutation 2
A>G in a2 domain
Mutation 3
c.4937A>G
Test Type
Genetic Disease/Disorder
Details
Von Willebrand?s disease (vWD) is a blood disease caused by a deficiency of von Willebrand Factor (vWF), an adhesive glycoprotein in the blood required for normal blood clotting. A lack of vWF impairs platelet stickiness and clumping. Symptoms can include: spontaneous hemorrhage from mucosal surfaces, nosebleeds, blood in the faeces, bloody urine, bleeding gums, excessive vaginal bleeding, bruising, prolonged bleeding after surgery or trauma, blood loss anemia. The inheritance of the severe forms (Types II and III) is autosomal recessive. The milder form (Type I) may be autosomal recessive or incompletely dominant. This is the most common hereditary blood clotting disorder in dogs.
Details 2
Von Willebrand?s disease (vWD) is a blood disease caused by a deficiency of von Willebrand Factor (vWF), an adhesive glycoprotein in the blood required for normal blood clotting. A lack of vWF impairs platelet stickiness and clumping. Symptoms can include: spontaneous hemorrhage from mucosal surfaces, nosebleeds, blood in the faeces, bloody urine, bleeding gums, excessive vaginal bleeding, bruising, prolonged bleeding after surgery or trauma, blood loss anemia. The inheritance of the severe forms (Types II and III) is autosomal recessive. The milder form (Type I) may be autosomal recessive or incompletely dominant. This is the most common hereditary blood clotting disorder in dogs.
Published
Kramer, JW., Venta, PJ., Klein, SR., Cao, Y., Schall, WD., Yuzbasiyan-Gurkan, V. : A von Willebrand's factor genomic nucleotide variant and polymerase chain reaction diagnostic test associated with inheritable type-2 von Willebrand's disease in a line of german shorthaired pointer dogs. Vet Pathol 41:221-8, 2004. Pubmed reference: 15133170. DOI: 10.1354/vp.41-3-221.

Breed Specific Data

Agrotis S.r.l.

GTP Name
Agrotis S.r.l.
Gene Name
VWF
Mutation
G>A in a2 domain; c.4937A>G

Anicom

GTP
GTP Name
Anicom
Gene Name
VWF
Mutation
c.4937A>G

BioBank AS

GTP Name
BioBank AS
Gene Name
VWF
Mutation
G>A in a2 domain; c.4937A>G

CAG GmbH Center for Animal Genetics

GTP Name
Center for Animal Genetics
Gene Name
VWF
Mutation
G>A in a2 domain
Nature of test
mutation test
GTP- or Breed-Specific Publications
Nichols, T.C., Hough, C., Agers??, H., Ezban, M., Lillicrap, D. : Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies.
Inheritance
AR
FCI Number
98
GTP Breed
German wirehaired pointing dog/ Deutsch Drahthaar

Certagen GmbH

GTP Name
Certagen GmbH
Gene Name
VWF
Mutation
G>A in a2 domain; c.4937A>G

CMSCH

GTP
GTP Name
CMSCH
Gene Name
VWF
Mutation
G>A in a2 domain; c.4937A>G

DNA My Dog

GTP Name
DNA My Dog
Gene Name
VWF
Mutation
G>A in a2 domain
Nature of test
mutation test
GTP- or Breed-Specific Publications
Nichols, T.C., Hough, C., Agers??, H., Ezban, M., Lillicrap, D. : Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies.
Inheritance
AR
This test is outsourced to:
Orivet
FCI Number
98
GTP Breed
German wirehaired pointing dog/ Deutsch Drahthaar

EVG Diagnostics

GTP Name
EVG Molecular Diagnostics
Gene Name
VWF
Mutation
g.38924099A>G
Nature of test
mutation test
GTP- or Breed-Specific Publications
Vet Pathol 41:221?228 (2004)

Genomia s.r.o

GTP Name
Genomia s.r.o
Gene Name
VWF
Mutation
c.4937A>G
Nature of test
mutation test
FCI Number
98
GTP Breed
German wirehaired pointing dog/ Deutsch Drahthaar

Genoscoper Laboratories Oy

GTP Name
Genoscoper Laboratories Oy
Gene Name
VWF
Mutation
G>A in a2 domain
Nature of test
mutation test
GTP- or Breed-Specific Publications
Nichols, T.C., Hough, C., Agers??, H., Ezban, M., Lillicrap, D. : Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies.
Inheritance
AR
FCI Number
98
GTP Breed
German wirehaired pointing dog/ Deutsch Drahthaar

GenSol Diagnostics

GTP Name
GenSol Diagnostics
Gene Name
VWF
Mutation
c.4937A>G

INNO

GTP
GTP Name
INNO
Gene Name
VWF
Mutation
G>A in a2 domain; c.4937A>G

Laboratorios Labocor S.L.

GTP Name
Laboratorios Labocor S.L.
Gene Name
VWF
Mutation
G>A in a2 domain; c.4937A>G

Laboklin Gmbh & Co. KG

GTP Name
Laboklin Gmbh & Co. KG
Gene Name
VWF
Mutation
G>A in a2 domain
Nature of test
mutation test
GTP- or Breed-Specific Publications
Nichols, T.C., Hough, C., Agers??, H., Ezban, M., Lillicrap, D. : Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies.
Inheritance
AR
FCI Number
98
GTP Breed
German wirehaired pointing dog/ Deutsch Drahthaar

Orivet Genetic Pet Care

GTP Name
Orivet Genetic Pet Care
Gene Name
VWF
Mutation
G>A in a2 domain
Nature of test
mutation test
GTP- or Breed-Specific Publications
Nichols, T.C., Hough, C., Agers??, H., Ezban, M., Lillicrap, D. : Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies.
Inheritance
AR
FCI Number
98
GTP Breed
German wirehaired pointing dog/ Deutsch Drahthaar

PharmaDNA

GTP
GTP Name
PharmaDNA
Gene Name
VWF
Mutation
G>A in a2 domain; c.4937A>G

Progènes-ADN

GTP Name
Progenes ADN
Gene Name
VWF
Mutation
G>A in a2 domain; c.4937A>G

Veterinary Genetics Laboratory

GTP Name
Veterinary Genetics Laboratory
Gene Name
VWF
Mutation
G>A in a2 domain
Nature of test
mutation test

VetGen LLC

GTP Name
VetGen LLC
Gene Name
VWF
Mutation
G>A in a2 domain

VHL Genetics

GTP Name
VHL Genetics
Gene Name
VWF
Mutation
G>A in a2 domain; c.4937A>G

Wisdom Health (formerly Mars Veterinary)

GTP Name
Wisdom Health (formerly Mars Veterinary)
Gene Name
VWF
Mutation
G>A in a2 domain
Nature of test
mutation test
GTP- or Breed-Specific Publications
Nichols, T.C., Hough, C., Agers??, H., Ezban, M., Lillicrap, D. : Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies.
Inheritance
AR
FCI Number
98
GTP Breed
German wirehaired pointing dog/ Deutsch Drahthaar

Zoolyx

GTP
GTP Name
Zoolyx
Gene Name
VWF
Mutation
G>A in a2 domain; c.4937A>G
×
×
  • Create New...

Important Information

By using this site, you agree to our Terms of Use.