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Nasal Parakeratosis

Breed: Labrador Retriever

Generic Phene Data

Breeds

Relevance Rating: There is some evidence or research available for these breeds

Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful in this breed

General

Disease Name
Nasal Parakeratosis
Mutation
c.972T>G
Test Type
Genetic Disease/Disorder
Details
Hereditary nasal parakeratosis (HNPK) causes the nose to dry out leading to chronic irritation and inflammation of the nasal skin. Dogs develop dry, gray to brown crusts on the surface and edge of the nose, painful cracking and a tendency for infection. Skin color can change from dark to light over time. Age of onset average 6 to 12 months. Although not life-threatening, continuous care is required to manage nasal crusting for the dog's life.
Details 2
Hereditary nasal parakeratosis (HNPK), an inherited monogenic autosomal recessive skin disorder, leads to crusts and fissures on the nasal planum of Labrador Retrievers... (From Jagannath et al, 2013) Hereditary nasal dermatitis is reported in 14 Labrador Retrievers and 4 Labrador Retriever crosses...The lesions were first noted between 6 and 12 months of age. Histopathological analysis revealed parakeratotic hyperkeratosis, often with marked multifocal accumulation of proteinaceous fluid between keratinocytes within the stratum corneum and superficial stratum spinosum. There was also a sub-basal lymphoplasmacytic infiltration within the superficial dermis...(From Page et al, 2003)
Published
Jagannathan, V., Bannoehr, J., Plattet, P., Hauswirth, R., Drögemüller, C., Drögemüller, M., Wiener, D.J., Doherr, M., Owczarek-Lipska, M., Galichet, A., Welle, M.M., Tengvall, K., Bergvall, K., Lohi, H., Rüfenacht, S., Linek, M., Paradis, M., Müller, E.J., Roosje, P., Leeb, T. : A mutation in the SUV39H2 gene in Labrador Retrievers with hereditary nasal parakeratosis (HNPK) provides insights into the epigenetics of keratinocyte differentiation. PLoS Genet 9:e1003848, 2013. Pubmed reference: 24098150. DOI: 10.1371/journal.pgen.1003848.

Breed Specific Data

Embark

GTP
GTP Name
Embark
GTP Disease Name
Dry Nose
Gene Name
SUV39H2
Mutation
c.972T>G
Nature of test
mutation test
GTP- or Breed-Specific Publications
Jagannathan, V., Bannoehr, J., Plattet, P., Hauswirth, R., Drógem?ller, C., Drógem?ller, M., Wiener, D.J., Doherr, M., Owczarek-Lipska, M., Galichet, A., Welle, M.M., Tengvall, K., Bergvall, K., Lohi,
Inheritance
AR
FCI Number
122
GTP Breed
Labrador Retriever

EVG Diagnostics

GTP Name
EVG Molecular Diagnostics
Gene Name
SUV39H2
Mutation
c.972T>G
Nature of test
mutation test
GTP- or Breed-Specific Publications
Anim Genet :, 2018. Pubmed reference: 29423952.
This test is outsourced to:
Genomia

Laboklin Gmbh & Co. KG

GTP Name
Laboklin Gmbh & Co. KG
GTP Disease Name
Dry Nose
Gene Name
SUV39H2
Mutation
c.972T>G
Nature of test
mutation test
GTP- or Breed-Specific Publications
Jagannathan, V., Bannoehr, J., Plattet, P., Hauswirth, R., Drógem?ller, C., Drógem?ller, M., Wiener, D.J., Doherr, M., Owczarek-Lipska, M., Galichet, A., Welle, M.M., Tengvall, K., Bergvall, K., Lohi,
Inheritance
AR
FCI Number
122
GTP Breed
Labrador Retriever

Orivet Genetic Pet Care

GTP Name
Orivet Genetic Pet Care
GTP Disease Name
Dry Nose
Gene Name
SUV39H2
Mutation
c.972T>G
Nature of test
mutation test
GTP- or Breed-Specific Publications
Jagannathan, V., Bannoehr, J., Plattet, P., Hauswirth, R., Drógem?ller, C., Drógem?ller, M., Wiener, D.J., Doherr, M., Owczarek-Lipska, M., Galichet, A., Welle, M.M., Tengvall, K., Bergvall, K., Lohi,
Inheritance
AR
FCI Number
122
GTP Breed
Labrador Retriever

Paw Print Genetics

GTP Name
Paw Print Genetics
GTP Disease Name
Dry Nose
Gene Name
SUV39H2
Mutation
c.972T>G
Nature of test
mutation test
FCI Number
122

Veterinary Genetics Laboratory

GTP Name
Veterinary Genetics Laboratory
GTP Disease Name
Dry Nose
Gene Name
SUV39H2
Mutation
c.972T>G
Nature of test
mutation test

VHL Genetics

GTP Name
VHL Genetics
Gene Name
SUV39H2
Mutation
c.972T>G

GenSol Diagnostics

GTP Name
GenSol Diagnostics
GTP Disease Name
Dry Nose
Gene Name
SUV39H2
Mutation
c.972T>G
GTP- or Breed-Specific Publications
Jagannathan, V., Bannoehr, J., Plattet, P., Hauswirth, R., Drógem?ller, C., Drógem?ller, M., Wiener, D.J., Doherr, M., Owczarek-Lipska, M., Galichet, A., Welle, M.M., Tengvall, K., Bergvall, K., Lohi,

Certagen GmbH

GTP Name
Certagen GmbH
Gene Name
SUV39H2
Mutation
c.972T>G

DNA My Dog

GTP Name
DNA My Dog
GTP Disease Name
Dry Nose
Gene Name
SUV39H2
Mutation
c.972T>G
Nature of test
mutation test
GTP- or Breed-Specific Publications
Jagannathan, V., Bannoehr, J., Plattet, P., Hauswirth, R., Drógem?ller, C., Drógem?ller, M., Wiener, D.J., Doherr, M., Owczarek-Lipska, M., Galichet, A., Welle, M.M., Tengvall, K., Bergvall, K., Lohi,
Inheritance
AR
This test is outsourced to:
Orivet
FCI Number
122
GTP Breed
Labrador Retriever

VetGen LLC

GTP Name
VetGen LLC
Gene Name
SUV39H2
Mutation
c.972T>G

Anicom

GTP
GTP Name
Anicom
GTP Disease Name
Dry Nose
Gene Name
SUV39H2
Mutation
c.972T>G

The Kennel Club

GTP Name
The Kennel Club
GTP Disease Name
Dry Nose
Gene Name
SUV39H2
Mutation
c.972T>G
This test is outsourced to:
Weatherby's

Agrotis S.r.l.

GTP Name
Agrotis S.r.l.
Gene Name
SUV39H2
Mutation
c.972T>G

BioBank AS

GTP Name
BioBank AS
Gene Name
SUV39H2
Mutation
c.972T>G

CMSCH

GTP
GTP Name
CMSCH
Gene Name
SUV39H2
Mutation
c.972T>G

INNO

GTP
GTP Name
INNO
Gene Name
SUV39H2
Mutation
c.972T>G

Laboratorios Labocor S.L.

GTP Name
Laboratorios Labocor S.L.
Gene Name
SUV39H2
Mutation
c.972T>G

PharmaDNA

GTP
GTP Name
PharmaDNA
Gene Name
SUV39H2
Mutation
c.972T>G

Progènes-ADN

GTP Name
Progenes ADN
Gene Name
SUV39H2
Mutation
c.972T>G

Zoolyx

GTP
GTP Name
Zoolyx
Gene Name
SUV39H2
Mutation
c.972T>G
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