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Trapped Neutrophil Syndrome (TNS)

Breed: Border Collie

Generic Phene Data

General

Disease Name
Trapped Neutrophil Syndrome (TNS)
OMIA
1428
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
OMIM
216550
Disease Code
TNS
Test Type
Genetic Disease/Disorder
Details
Trapped Neutrophil Syndrome (TNS) is a mutation causing the dog's infection-fighting white blood cells to not be released from the bone marrow. The dog's immune system is unable to fight off infections and the dog eventually dies, usually when they are a few months old. Age of onset from birth, but symptoms may not be apparent until 7 months. An affected puppy may not show any specific symptoms, other than susceptibility to infection, but may be smaller and less healthy than unaffected puppies.
Details 2
Trapped Neutrophil Syndrome (TNS) is a mutation causing the dog's infection-fighting white blood cells to not be released from the bone marrow. The dog's immune system is unable to fight off infections and the dog eventually dies, usually when they are a few months old. Age of onset from birth, but symptoms may not be apparent until 7 months. An affected puppy may not show any specific symptoms, other than susceptibility to infection, but may be smaller and less healthy than unaffected puppies.
Published
Shearman J.R. and A.N. Wilton. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics 2011 12:258.
Published 2
Mizukami, K., Yabuki, A., Kawamichi, T., Chang, H.S., Rahman, M.M., Uddin, M.M., Kohyama, M., Yamato, O. : Real-time PCR genotyping assay for canine trapped neutrophil syndrome and high frequency of the mutant allele in Border collies. Vet J 195:260-1, 2013. Pubmed reference: 22795605. DOI: 10.1016/j.tvjl.2012.06.014.
Published 3
Mizukami, K., Yabuki, A., Kohyama, M., Kushida, K., Rahman, M.M., Uddin, M.M., Sawa, M., Yamato, O. : Molecular prevalence of multiple genetic disorders in Border collies in Japan and recommendations for genetic counselling. Vet J 214:21-3, 2016. Pubmed reference: 27387721. DOI: 10.1016/j.tvjl.2016.05.004.
Body/System/Process
Blood
Inheritance
AR
Gene Name Text
vacuolar protein sorting 13 homolog B (yeast)

Breed Specific Data

DNA My Dog

Link to GTP
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Nature of test
mutation test
GTP- or Breed-Specific Publications
Shearman J.R. and A.N. Wilton. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics 2011 12:258.
Application in the Breed
Carriers may be bred to normal animals (N/tns x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/tns x N/tns) nor of affected animals (tns/tns). Elongated, ferret shaped skull and smaller than littermates. Immune system compromised (chronic infections)
Inheritance
AR

GenSol Diagnostics

Link to GTP
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
GTP- or Breed-Specific Publications
Shearman J.R. and A.N. Wilton. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics 2011 12:258.
Application in the Breed
Carriers may be bred to normal animals (N/tns x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/tns x N/tns) nor of affected animals (tns/tns). Elongated, ferret shaped skull and smaller than littermates. Immune system compromised (chronic infections)

GenSol Diagnostics

Link to GTP
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
GTP- or Breed-Specific Publications
Shearman J.R. and A.N. Wilton. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics 2011 12:258.
Application in the Breed
Carriers may be bred to normal animals (N/tns x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/tns x N/tns) nor of affected animals (tns/tns). Elongated, ferret shaped skull and smaller than littermates. Immune system compromised (chronic infections)

Wisdom Health (formerly Mars Veterinary)

Link to GTP
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Nature of test
mutation test
GTP- or Breed-Specific Publications
Shearman J.R. and A.N. Wilton. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics 2011 12:258.
Application in the Breed
Carriers may be bred to normal animals (N/tns x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/tns x N/tns) nor of affected animals (tns/tns). Elongated, ferret shaped skull and smaller than littermates. Immune system compromised (chronic infections)
Inheritance
AR

VHL Genetics

Link to GTP
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Nature of test
mutation test
GTP- or Breed-Specific Publications
Shearman J.R. and A.N. Wilton. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics 2011 12:258.
Application in the Breed
Carriers may be bred to normal animals (N/tns x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/tns x N/tns) nor of affected animals (tns/tns). Elongated, ferret shaped skull and smaller than littermates. Immune system compromised (chronic infections)
Inheritance
AR

Veterinary Genetics Laboratory

Link to GTP
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Nature of test
mutation test
GTP- or Breed-Specific Publications
Shearman J.R. and A.N. Wilton. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics 2011 12:258.
Application in the Breed
Carriers may be bred to normal animals (N/tns x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/tns x N/tns) nor of affected animals (tns/tns). Elongated, ferret shaped skull and smaller than littermates. Immune system compromised (chronic infections)
Inheritance
AR

Paw Print Genetics

Link to GTP
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Nature of test
mutation test

Orivet Genetic Pet Care

Link to GTP
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Nature of test
mutation test
GTP- or Breed-Specific Publications
Shearman J.R. and A.N. Wilton. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics 2011 12:258.
Application in the Breed
Carriers may be bred to normal animals (N/tns x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/tns x N/tns) nor of affected animals (tns/tns). Elongated, ferret shaped skull and smaller than littermates. Immune system compromised (chronic infections)
Inheritance
AR

OptiGen

Link to GTP
GTP
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Nature of test
mutation test
GTP- or Breed-Specific Publications
Shearman J.R. and A.N. Wilton. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics 2011 12:258.
Application in the Breed
Carriers may be bred to normal animals (N/tns x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/tns x N/tns) nor of affected animals (tns/tns). Elongated, ferret shaped skull and smaller than littermates. Immune system compromised (chronic infections)
Inheritance
AR

Laboklin Gmbh & Co. KG

Link to GTP
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Nature of test
mutation test
GTP- or Breed-Specific Publications
Shearman J.R. and A.N. Wilton. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics 2011 12:258.
Application in the Breed
Carriers may be bred to normal animals (N/tns x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/tns x N/tns) nor of affected animals (tns/tns). Elongated, ferret shaped skull and smaller than littermates. Immune system compromised (chronic infections)
Inheritance
AR

Genoscoper Laboratories Oy

Link to GTP
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Nature of test
mutation test
GTP- or Breed-Specific Publications
Shearman J.R. and A.N. Wilton. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics 2011 12:258.
Application in the Breed
Carriers may be bred to normal animals (N/tns x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/tns x N/tns) nor of affected animals (tns/tns). Elongated, ferret shaped skull and smaller than littermates. Immune system compromised (chronic infections)
Inheritance
AR

Genomia s.r.o

Link to GTP
Gene Name
VPS13B
Mutation
g.4411956_4411960delGTTT
Nature of test
mutation test

EVG Diagnostics

Link to GTP
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Nature of test
mutation test
GTP- or Breed-Specific Publications
J Vet Med Sci. 2012 Jun;74(6):797-800.

Embark

Link to GTP
GTP
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Nature of test
mutation test
GTP- or Breed-Specific Publications
Shearman J.R. and A.N. Wilton. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics 2011 12:258.
Application in the Breed
Carriers may be bred to normal animals (N/tns x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/tns x N/tns) nor of affected animals (tns/tns). Elongated, ferret shaped skull and smaller than littermates. Immune system compromised (chronic infections)
Inheritance
AR

CAG GmbH Center for Animal Genetics

Link to GTP
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Nature of test
mutation test
GTP- or Breed-Specific Publications
Shearman J.R. and A.N. Wilton. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics 2011 12:258.
Application in the Breed
Carriers may be bred to normal animals (N/tns x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/tns x N/tns) nor of affected animals (tns/tns). Elongated, ferret shaped skull and smaller than littermates. Immune system compromised (chronic infections)
Inheritance
AR

Animal Health Trust (UK)

Link to GTP
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Nature of test
mutation test
GTP- or Breed-Specific Publications
Shearman J.R. and A.N. Wilton. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics 2011 12:258.
Application in the Breed
Carriers may be bred to normal animals (N/tns x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/tns x N/tns) nor of affected animals (tns/tns). Elongated, ferret shaped skull and smaller than littermates. Immune system compromised (chronic infections)
Inheritance
AR
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