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Epidermolytic Hyperkeratosis

Breed: Norfolk Terrier

Generic Phene Data

Breeds

Relevance Rating: There is moderate evidence or research available in this breed

General

Disease Name
Epidermolytic Hyperkeratosis
Mutation
GT>TT donor splice site of intron 5
Test Type
Genetic Disease/Disorder
Details
Epidermolytic Hyperkeratosis is a form of ichthyosis. Age of onset reported as adult dogs with the disease causing generalised dark pigmentation and fragile skin.
Details 2
Epidermolytic Hyperkeratosis is a form of ichthyosis. "Adult dogs with the disease had generalized, pigmented hyperkeratosis with epidermal fragility." (Credille et al., 2005)
Published
Credille, KM., Barnhart, KF., Minor, JS., Dunstan, RW. : Mild recessive epidermolytic hyperkeratosis associated with a novel keratin 10 donor splice-site mutation in a family of Norfolk terrier dogs. Br J Dermatol 153:51-8, 2005. Pubmed reference: 16029326. DOI: 10.1111/j.1365-2133.2005.06735.x.

Breed Specific Data

Agrotis S.r.l.

GTP Name
Agrotis S.r.l.
Gene Name
KRT10
Mutation
GT>TT donor splice site of intron 5

BioBank AS

GTP Name
BioBank AS
Gene Name
KRT10
Mutation
GT>TT donor splice site of intron 5

CAG GmbH Center for Animal Genetics

GTP Name
Center for Animal Genetics
GTP Disease Name
Ichthyosis, Norfolk Terrier
GTP Disease Synonym
epidermic hyperkeratosis
Gene Name
KRT10
Mutation
GT>TT donor splice site of intron 5
Nature of test
mutation test
GTP- or Breed-Specific Publications
Credille, KM., Barnhart, KF., Minor, JS., Dunstan, RW. : Mild recessive epidermolytic hyperkeratosis associated with a novel keratin 10 donor splice-site mutation in a family of Norfolk terrier dogs
Application in the Breed
Carriers may be bred to normal animals (N/eh x N/N) . Offspring should be tested before breeding. No breeding of two carriers (N/eh x N/eh) nor of affected animals (eh/eh). Areas of skin are thick and darkened and fragile.
Inheritance
AR
FCI Number
272
GTP Breed
Norfolk Terrier

Certagen GmbH

GTP Name
Certagen GmbH
Gene Name
KRT10
Mutation
GT>TT donor splice site of intron 5

CMSCH

GTP
GTP Name
CMSCH
Gene Name
KRT10
Mutation
GT>TT donor splice site of intron 5

DNA My Dog

GTP Name
DNA My Dog
GTP Disease Name
Ichthyosis, Norfolk Terrier
GTP Disease Synonym
epidermic hyperkeratosis
Gene Name
KRT10
Mutation
GT>TT donor splice site of intron 5
Nature of test
mutation test
GTP- or Breed-Specific Publications
Credille, KM., Barnhart, KF., Minor, JS., Dunstan, RW. : Mild recessive epidermolytic hyperkeratosis associated with a novel keratin 10 donor splice-site mutation in a family of Norfolk terrier dogs
Application in the Breed
Carriers may be bred to normal animals (N/eh x N/N) . Offspring should be tested before breeding. No breeding of two carriers (N/eh x N/eh) nor of affected animals (eh/eh). Areas of skin are thick and darkened and fragile.
Inheritance
AR
This test is outsourced to:
Orivet
FCI Number
272
GTP Breed
Norfolk Terrier

Genoscoper Laboratories Oy

GTP Name
Genoscoper Laboratories Oy
GTP Disease Name
Ichthyosis, Norfolk Terrier
GTP Disease Synonym
epidermic hyperkeratosis
Gene Name
KRT10
Mutation
GT>TT donor splice site of intron 5
Nature of test
mutation test
GTP- or Breed-Specific Publications
Credille, KM., Barnhart, KF., Minor, JS., Dunstan, RW. : Mild recessive epidermolytic hyperkeratosis associated with a novel keratin 10 donor splice-site mutation in a family of Norfolk terrier dogs
Application in the Breed
Carriers may be bred to normal animals (N/eh x N/N) . Offspring should be tested before breeding. No breeding of two carriers (N/eh x N/eh) nor of affected animals (eh/eh). Areas of skin are thick and darkened and fragile.
Inheritance
AR
FCI Number
272
GTP Breed
Norfolk Terrier

INNO

GTP
GTP Name
INNO
Gene Name
KRT10
Mutation
GT>TT donor splice site of intron 5

Laboratorios Labocor S.L.

GTP Name
Laboratorios Labocor S.L.
Gene Name
KRT10
Mutation
GT>TT donor splice site of intron 5

Laboklin Gmbh & Co. KG

GTP Name
Laboklin Gmbh & Co. KG
GTP Disease Name
Ichthyosis, Norfolk Terrier
GTP Disease Synonym
epidermic hyperkeratosis
Gene Name
KRT10
Mutation
GT>TT donor splice site of intron 5
Nature of test
mutation test
GTP- or Breed-Specific Publications
Credille, KM., Barnhart, KF., Minor, JS., Dunstan, RW. : Mild recessive epidermolytic hyperkeratosis associated with a novel keratin 10 donor splice-site mutation in a family of Norfolk terrier dogs
Application in the Breed
Carriers may be bred to normal animals (N/eh x N/N) . Offspring should be tested before breeding. No breeding of two carriers (N/eh x N/eh) nor of affected animals (eh/eh). Areas of skin are thick and darkened and fragile.
Inheritance
AR
FCI Number
272
GTP Breed
Norfolk Terrier

Orivet Genetic Pet Care

GTP Name
Orivet Genetic Pet Care
GTP Disease Name
Ichthyosis, Norfolk Terrier
GTP Disease Synonym
epidermic hyperkeratosis
Gene Name
KRT10
Mutation
GT>TT donor splice site of intron 5
Nature of test
mutation test
GTP- or Breed-Specific Publications
Credille, KM., Barnhart, KF., Minor, JS., Dunstan, RW. : Mild recessive epidermolytic hyperkeratosis associated with a novel keratin 10 donor splice-site mutation in a family of Norfolk terrier dogs
Application in the Breed
Carriers may be bred to normal animals (N/eh x N/N) . Offspring should be tested before breeding. No breeding of two carriers (N/eh x N/eh) nor of affected animals (eh/eh). Areas of skin are thick and darkened and fragile.
Inheritance
AR
FCI Number
272
GTP Breed
Norfolk Terrier

Paw Print Genetics

GTP Name
Paw Print Genetics
GTP Disease Name
Ichthyosis, Norfolk Terrier
Gene Name
KRT10
Mutation
GT>TT donor splice site of intron 5
Nature of test
mutation test
GTP- or Breed-Specific Publications
Credille, KM., Barnhart, KF., Minor, JS., Dunstan, RW. : Mild recessive epidermolytic hyperkeratosis associated with a novel keratin 10 donor splice-site mutation in a family of Norfolk terrier dogs
Application in the Breed
Carriers may be bred to normal animals (N/eh x N/N) . Offspring should be tested before breeding. No breeding of two carriers (N/eh x N/eh) nor of affected animals (eh/eh). Areas of skin are thick and darkened and fragile.
Inheritance
AR
FCI Number
272
GTP Breed
Norfolk Terrier

PharmaDNA

GTP
GTP Name
PharmaDNA
Gene Name
KRT10
Mutation
GT>TT donor splice site of intron 5

Progènes-ADN

GTP Name
Progenes ADN
Gene Name
KRT10
Mutation
GT>TT donor splice site of intron 5

VHL Genetics

GTP Name
VHL Genetics
Gene Name
KRT10
Mutation
GT>TT donor splice site of intron 5

Wisdom Health (formerly Mars Veterinary)

GTP Name
Wisdom Health (formerly Mars Veterinary)
GTP Disease Name
Ichthyosis, Norfolk Terrier
GTP Disease Synonym
epidermic hyperkeratosis
Gene Name
KRT10
Mutation
GT>TT donor splice site of intron 5
Nature of test
mutation test
GTP- or Breed-Specific Publications
Credille, KM., Barnhart, KF., Minor, JS., Dunstan, RW. : Mild recessive epidermolytic hyperkeratosis associated with a novel keratin 10 donor splice-site mutation in a family of Norfolk terrier dogs
Application in the Breed
Carriers may be bred to normal animals (N/eh x N/N) . Offspring should be tested before breeding. No breeding of two carriers (N/eh x N/eh) nor of affected animals (eh/eh). Areas of skin are thick and darkened and fragile.
Inheritance
AR
FCI Number
272
GTP Breed
Norfolk Terrier

Zoolyx

GTP
GTP Name
Zoolyx
Gene Name
KRT10
Mutation
GT>TT donor splice site of intron 5
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