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Trapped Neutrophil Syndrome (TNS)

Breed: Australian Cobberdog

Generic Phene Data

Breeds

Relevance Rating: There is some evidence or research available in this breed

Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful for these breeds

General

Disease Name
Trapped Neutrophil Syndrome (TNS)
Mutation
g.4411950_4411953delGTTT
Test Type
Genetic Disease/Disorder
Details
Trapped Neutrophil Syndrome (TNS) is a mutation causing the dog's infection-fighting white blood cells to not be released from the bone marrow. The dog's immune system is unable to fight off infections and the dog eventually dies, usually when they are a few months old. Age of onset from birth, but symptoms may not be apparent until 7 months. An affected puppy may not show any specific symptoms, other than susceptibility to infection, but may be smaller and less healthy than unaffected puppies.
Details 2
Trapped Neutrophil Syndrome (TNS) is a mutation causing the dog's infection-fighting white blood cells to not be released from the bone marrow. The dog's immune system is unable to fight off infections and the dog eventually dies, usually when they are a few months old. Age of onset from birth, but symptoms may not be apparent until 7 months. An affected puppy may not show any specific symptoms, other than susceptibility to infection, but may be smaller and less healthy than unaffected puppies.
Published
Shearman J.R. and A.N. Wilton. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics 2011 12:258.

Breed Specific Data

Agrotis S.r.l.

GTP Name
Agrotis S.r.l.
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT

BioBank AS

GTP Name
BioBank AS
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT

Certagen GmbH

GTP Name
Certagen GmbH
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT

CMSCH

GTP
GTP Name
CMSCH
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT

DNA My Dog

GTP Name
DNA My Dog
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Nature of test
mutation test
GTP- or Breed-Specific Publications
Shearman J.R. and A.N. Wilton. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics 2011 12:258.
Application in the Breed
Carriers may be bred to normal animals (N/tns x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/tns x N/tns) nor of affected animals (tns/tns). Elongated, ferret shaped skull and smaller than littermates. Immune system compromised (chronic infections)
Inheritance
AR
This test is outsourced to:
Orivet
FCI Number
-27
GTP Breed
Australian Cobberdog

GenSol Diagnostics

GTP Name
GenSol Diagnostics
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
GTP- or Breed-Specific Publications
Shearman J.R. and A.N. Wilton. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics 2011 12:258.
Application in the Breed
Carriers may be bred to normal animals (N/tns x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/tns x N/tns) nor of affected animals (tns/tns). Elongated, ferret shaped skull and smaller than littermates. Immune system compromised (chronic infections)

INNO

GTP
GTP Name
INNO
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT

Laboratorios Labocor S.L.

GTP Name
Laboratorios Labocor S.L.
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT

Orivet Genetic Pet Care

GTP Name
Orivet Genetic Pet Care
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Nature of test
mutation test
GTP- or Breed-Specific Publications
Shearman J.R. and A.N. Wilton. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics 2011 12:258.
Application in the Breed
Carriers may be bred to normal animals (N/tns x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/tns x N/tns) nor of affected animals (tns/tns). Elongated, ferret shaped skull and smaller than littermates. Immune system compromised (chronic infections)
Inheritance
AR
FCI Number
-27
GTP Breed
Australian Cobberdog

PharmaDNA

GTP
GTP Name
PharmaDNA
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT

Progènes-ADN

GTP Name
Progenes ADN
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT

VHL Genetics

GTP Name
VHL Genetics
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT

Zoolyx

GTP
GTP Name
Zoolyx
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
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