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Neuropathy, Sensory Ataxic

Breed: Goldendoodle

Generic Phene Data

Breeds

Relevance Rating: There is some evidence or research available in this breed

Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful in this breed

General

Disease Name
Neuropathy, Sensory Ataxic
Mutation
c.5304delA
Test Type
Genetic Disease/Disorder
Details
Sensory ataxic neuropathy (SAN) is a slowly progressive neurological disorder causing degeneration in the central and peripheral nervous system. Signs include: ataxia, postural reaction deficits, reduced or absent spinal reflexes. Age of onset from puppyhood. Around half of dogs are euthanized before three years of age, if badly affected.
Details 2
Sensory ataxic neuropathy (SAN) is a recently identified neurological disorder in golden retrievers...The mutation could be traced back to a common ancestor of all affected dogs that lived in the 1970s...SAN has an insidious onset during puppyhood, followed by slow progression. Males and females are affected at similar frequencies. Affected dogs are ataxic, have postural reaction deficits and reduced or absent spinal reflexes. They have no pronounced muscle atrophy, and the dogs do not seem to be in pain. Electrophysiological examination revealed that they have reduced conduction velocities of nerve impulses in sensory nerves. Pathological examination indicated degenerative changes both in the central and peripheral nervous system. Approximately fifty percent of the affected dogs were euthanized before three years of age...(From Baranowska et al, 2009)
Published
Baranowska, I., Jäderlund, K.H., Nennesmo, I., Holmqvist, E., Heidrich, N., Larsson, N.G., Andersson, G., Wagner, E.G., Hedhammar, A., Wibom, R., Andersson, L. : Sensory ataxic neuropathy in golden retriever dogs is caused by a deletion in the mitochondrial tRNATyr gene. PLoS Genet 5:e1000499, 2009. Pubmed reference: 19492087. DOI: 10.1371/journal.pgen.1000499.

Breed Specific Data

Agrotis S.r.l.

GTP Name
Agrotis S.r.l.
Breed
Gene Name
tRNA-Tyr
Mutation
c.5304delA

BioBank AS

GTP Name
BioBank AS
Breed
Gene Name
tRNA-Tyr
Mutation
c.5304delA

Certagen GmbH

GTP Name
Certagen GmbH
Breed
Gene Name
tRNA-Tyr
Mutation
c.5304delA

CMSCH

GTP
GTP Name
CMSCH
Breed
Gene Name
tRNA-Tyr
Mutation
c.5304delA

INNO

GTP
GTP Name
INNO
Breed
Gene Name
tRNA-Tyr
Mutation
c.5304delA

Laboratorios Labocor S.L.

GTP Name
Laboratorios Labocor S.L.
Breed
Gene Name
tRNA-Tyr
Mutation
c.5304delA

Paw Print Genetics

GTP Name
Paw Print Genetics
Breed
GTP Disease Name
Sensory Ataxic Neuropathy
Gene Name
tRNA-Tyr
Mutation
c.5304delA
Nature of test
mutation test
FCI Number
-43

PharmaDNA

GTP
GTP Name
PharmaDNA
Breed
Gene Name
tRNA-Tyr
Mutation
c.5304delA

Progènes-ADN

GTP Name
Progenes ADN
Breed
Gene Name
tRNA-Tyr
Mutation
c.5304delA

VetGen LLC

GTP Name
VetGen LLC
Breed
Gene Name
tRNA-tyr
Mutation
c.5304delA

VHL Genetics

GTP Name
VHL Genetics
Breed
Gene Name
tRNA-Tyr
Mutation
c.5304delA

Zoolyx

GTP
GTP Name
Zoolyx
Breed
Gene Name
tRNA-Tyr
Mutation
c.5304delA
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