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Improper Coat/Furnishings

Breed: ALL

Generic Phene Data

General

Disease Name
Improper Coat/Furnishings
OMIA
1498
Gene Name
RSPO2
Mutation
167 bp 3' UTR insertion
Disease Code
IC
Test Type
Other Genetic Traits
Details
The IC Locus determines for some breeds the variation in the dog's coat that makes its texture and appearance look different from the breed standard - i.e. change in hair type from wired to straight. It can also influence the presense or absense of "furnishings" (mustache and eyebrows). For some breeds and crosses, having the Improper Coat (IC) variation appears to be associated with dogs prone to shedding. Inherited phenotypes include: furnishings + proper coat, furnishings + improper coat, no furnishings + improper coat. The overall coat type is dependent on the combination of this dog's genotypes at the L, Cu, and IC loci.
Details 2
The IC Locus determines for some breeds the variation in the dog's coat that makes its texture and appearance look different from the breed standard - i.e. change in hair type from wired to straight. It can also influence the presense or absense of "furnishings" (mustache and eyebrows). For some breeds and crosses, having the Improper Coat (IC) variation appears to be associated with dogs prone to shedding. Inherited phenotypes include: furnishings + proper coat, furnishings + improper coat, no furnishings + improper coat. The overall coat type is dependent on the combination of this dog's genotypes at the L, Cu, and IC loci.
Published
Parker, HG., Chase, K., Cadieu, E., Lark, KG., Ostrander, EA. : An insertion in the RSPO2 gene correlates with improper coat in the Portuguese water dog. J Hered 101:612-7, 2010. Pubmed reference: 20562213. DOI: 10.1093/jhered/esq068.
Published 2
Parker, H.G., Harris, A., Dreger, D.L., Davis, B.W., Ostrander, E.A. : The bald and the beautiful: hairlessness in domestic dog breeds. Philos Trans R Soc Lond B Biol Sci 372:, 2017. Pubmed reference: 27994129. DOI: 10.1098/rstb.2015.0488.
Body/System/Process
Coat Colour/Pattern/Type
Inheritance
A

Breed Specific Data

GenSol Diagnostics

Link to GTP
Breed
ALL
GTP Disease Name
Improper coat
Gene Name
RSPO2
Mutation
167 bp insertion in 3'UTR region

GenSol Diagnostics

Link to GTP
Breed
ALL
GTP Disease Name
Improper coat
Gene Name
RSPO2
Mutation
167 bp insertion in 3'UTR region

VHL Genetics

Link to GTP
Breed
ALL
Gene Name
RSPO2
Mutation
167 bp insertion in 3'UTR region
Nature of test
mutation test
Inheritance
AR

Veterinary Genetics Laboratory

Link to GTP
Breed
ALL
GTP Disease Name
Improper coat
Gene Name
RSPO2
Mutation
167 bp insertion in 3'UTR region
Nature of test
mutation test
GTP- or Breed-Specific Publications
Cadieu E, Neff MW, Quignon P, Walsh K, Chase K, Parker HG, Vonholdt BM, Rhue A, Boyko A, Byers A, Wong A, Mosher DS, Elkahloun AG, Spady TC, Andr?? C, Lark KG, Cargill M, Bustamante CD, Wayne RK, Ostrander EA. Coat variation in the domestic dog is governed

Laboklin Gmbh & Co. KG

Link to GTP
Breed
ALL
Gene Name
RSPO2
Mutation
167 bp insertion in 3'UTR region
Nature of test
mutation test
Inheritance
AR

Laboklin Gmbh & Co. KG

Link to GTP
Breed
ALL
GTP Disease Name
Improper coat
Gene Name
RSPO2
Mutation
167 bp insertion in 3'UTR region
Nature of test
mutation test

Genoscoper Laboratories Oy

Link to GTP
Breed
ALL
GTP Disease Name
Improper coat
Gene Name
RSPO2
Mutation
167 bp insertion in 3'UTR region
Nature of test
mutation test

CAG GmbH Center for Animal Genetics

Link to GTP
Breed
ALL
GTP Disease Name
Improper coat
Gene Name
RSPO2
Mutation
167 bp insertion in 3'UTR region
Nature of test
mutation test

Antagene

Link to GTP
GTP
Breed
ALL
GTP Disease Name
Improper coat
Gene Name
RSPO2
Mutation
167 bp insertion in 3'UTR region
Nature of test
mutation test
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