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Coat Colour Dilution, Alopecia

Breed: ALL

Generic Phene Data

Breeds
ALL
Kai
Pug

General

Disease Name
Coat Colour Dilution, Alopecia
Disease Name 2
Coat Colour D-Locus Improved (MLPH)
OMIA
31
Gene Name
MLPH
Mutation
c.-22G>A
Mutation 2
c.705G>C
OMIM
609227
Test Type
Other Genetic Traits
Details
Responsible for "dilute" pigmentation, and colour dilution-related alopecia (CDA). CDA causes patches of hair thinning or loss, and may also include flaky and/or itchy skin. The condition is most commonly seen in dogs with a "blue" or "fawn" coat. As some tests are breed or type specific, please use care when selecting the right test for your dog
Published
Drögemüller, C., Philipp, U., Haase, B., Günzel-Apel, A.R., Leeb, T. : A noncoding melanophilin gene (MLPH) SNP at the splice donor of exon 1 represents a candidate causal mutation for coat color dilution in dogs. J Hered 98:468-73, 2007. Pubmed reference: 17519392. DOI: 10.1093/jhered/esm021.
Body/System/Process
Coat Colour/Pattern/Type
Inheritance
AR

Breed Specific Data

Antagene

Link to GTP
GTP
Breed
ALL
GTP Disease Name
Alopecia, colour mutant
GTP Disease Synonym
Coat color dilution alopecia, Coat color mutant alopecia, Blue doberman syndrome, Black Hair Follicular Dysplasia, CDA
Gene Name
MLPH
Mutation
c.-22G>A
Nature of test
mutation test
Inheritance
AR

CAG GmbH Center for Animal Genetics

Link to GTP
Breed
ALL
GTP Disease Name
Alopecia, colour mutant
GTP Disease Synonym
Coat color dilution alopecia, Coat color mutant alopecia, Blue doberman syndrome, Black Hair Follicular Dysplasia, CDA
Gene Name
MLPH
Mutation
c.-22G>A
Nature of test
mutation test
Inheritance
AR

DNA My Dog

Link to GTP
Breed
ALL
GTP Disease Name
Alopecia, colour mutant
GTP Disease Synonym
Coat color dilution alopecia, Coat color mutant alopecia, Blue doberman syndrome, Black Hair Follicular Dysplasia, CDA
Gene Name
MLPH
Mutation
c.-22G>A
Nature of test
mutation test
Inheritance
AR

Orivet Genetic Pet Care

Link to GTP
Breed
ALL
GTP Disease Name
Alopecia, colour mutant
GTP Disease Synonym
Coat color dilution alopecia, Coat color mutant alopecia, Blue doberman syndrome, Black Hair Follicular Dysplasia, CDA
Gene Name
MLPH
Mutation
c.-22G>A
Nature of test
mutation test
Inheritance
AR

Veterinary Genetics Laboratory

Link to GTP
Breed
ALL
GTP Disease Name
Alopecia, colour mutant
GTP Disease Synonym
Coat color dilution alopecia, Coat color mutant alopecia, Blue doberman syndrome, Black Hair Follicular Dysplasia, CDA
Gene Name
MLPH
Mutation
c.-22G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Drógem?ller, C., Philipp, U., Haase, B., G?nzel-Apel, A.R., Leeb, T. :A noncoding melanophilin gene (MLPH) SNP at the splice donor of exon 1 represents a candidate causal mutation for coat color dilution in dogs. J Hered 98:468-73, 2007. Pubmed reference:
Inheritance
AR

Genomia s.r.o

Link to GTP
Breed
ALL
GTP Disease Name
Alopecia, colour mutant
GTP Disease Synonym
Alopecia
Gene Name
MLPH
Mutation
c.-22G>A
Nature of test
mutation test
Inheritance
AR

Laboklin Gmbh & Co. KG

Link to GTP
Breed
ALL
GTP Disease Name
D Locus (Dilute)
Gene Name
MLPH
Mutation
unpublished
Nature of test
mutation test
Inheritance
AR

VHL Genetics

Link to GTP
Breed
ALL
GTP Disease Name
D Locus (Dilute)
Gene Name
MLPH
Mutation
unpublished
Nature of test
mutation test
Inheritance
AR

Paw Print Genetics

Link to GTP
Breed
ALL
GTP Disease Name
D Locus (Dilute)
Gene Name
MLPH
Mutation
unpublished
Nature of test
mutation test
Inheritance
AR

GenSol Diagnostics

Link to GTP
Breed
ALL
GTP Disease Name
Alopecia, colour mutant
Gene Name
MLPH
Mutation
c.-22G>A
GTP- or Breed-Specific Publications
Drógemuller, C., Philipp, U., Haase, B., Gunzel-Apel, A.R., Leeb, T. :A noncoding melanophilin gene (MLPH) SNP at the splice donor of exon 1 represents a candidate causal mutation for coat color dilution in dogs. J Hered 98:468-73, 2007.
Application in the Breed
Test is only giving information to coat colors, not causal for alopecia for all breeds. D-Locus; D1 for all breeds, D2 for Chow Chow, Sloughi, Tai, Ridgeback Dog
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